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Preparation and properties of a dually responsive hydrogels based on polyampholyte for oral delivery of drugs

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Abstract

Novel of temperature and pH sensitive hydrogels composed of polyampholyte (casein) and poly(N-isopropylacrylamide) were successfully synthesized via free radical polymerization. The swelling behavior of the obtained hydrogel was investigated and it was found that the synthesized hydrogel has a sensitivity to temperature, pH, and the crosslinker content. The drug release of this hydrogel was determined with salicylic acid employed as the model drug. It found that the release of salicylic acid from the hydrogel particles was affected by temperature, pH, and the crosslinker content in the copolymer hydrogels. Therefore, the novel pH and temperature sensitive hydrogel seem to be of great promise in pH and temperature sensitive oral drug release systems.

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Authors and Affiliations

  1. R&D Center of Polymer Science and Technology, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, People’s Republic of China

    Zhi-Feng Cao, Yong Jin, Qing Miao, Chun-Yan Ma & Biao Zhang

  2. Graduate School of Chinese Academy of Science, Beijing, 100039, People’s Republic of China

    Zhi-Feng Cao, Qing Miao, Chun-Yan Ma & Biao Zhang

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  1. Zhi-Feng Cao
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  2. Yong Jin
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  3. Qing Miao
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  4. Chun-Yan Ma
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  5. Biao Zhang
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Correspondence to Zhi-Feng Cao.

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Cao, ZF., Jin, Y., Miao, Q. et al. Preparation and properties of a dually responsive hydrogels based on polyampholyte for oral delivery of drugs. Polym. Bull. 70, 2675–2689 (2013). https://doi.org/10.1007/s00289-013-0975-3

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  • DOI: https://doi.org/10.1007/s00289-013-0975-3

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