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Sacrificial PSS-doped CaCO3 templates to prepare chitosan capsules and their deformation under bulk pressure

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Abstract

To prepare microcapsules composed of chitosan (CS), a templating method is developed using poly(styrene sulfonate) (PSS)-doped porous calcium carbonate (CaCO3) templates as sacrificial templates. First, CS is absorbed onto PSS-doped porous CaCO3 templates, and then the absorbed CS is covalently cross-linked with each other by using glutaraldehyde. Porous CaCO3 templates are dissolved with disodium ethylenediaminetetraacetate dihydrate and the resultant CS capsules ranged from 2 to 5 μm in diameter. Nitrogen adsorption–desorption analysis are applied to characterize the porous CaCO3 templates, the BET surface area and total pore volume are 220 m2/g and 0.36 cm3/g, respectively. Field-emission scanning electron microscopy and transmission electron microscopy were used to characterize the CS capsules morphology. Confocal laser scanning microscopy images reveal that the capsules have been labeled with green fluorescein isothiocyanate. The gradual deformation of capsule in response to bulk osmotic pressure created by CS solutions has also been discussed.

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References

  1. Tam SK, Bilodeau S, Dusseault J, Langlois G, Hallé JP, Yahia LH (2011) Biocompatibility and physicochemical characteristics of alginate–polycation microcapsules. Acta Biomater 7:1683–1692

    Article  CAS  Google Scholar 

  2. Radziuk D, Shchukin DG, Skirtach A, Möhwald H, Sukhorukov G (2007) Synthesis of silver nanoparticles for remote opening of polyelectrolyte microcapsules. Langmuir 23:4612–4617

    Article  CAS  Google Scholar 

  3. Endo Y, Sato K, Anzai JI (2011) Preparation of avidin-containing polyelectrolyte microcapsules and their uptake and release properties. Polym Bull 66:711–720

    Article  CAS  Google Scholar 

  4. Guerrero-Martínez A, Barbosa S, Pastoriza-Santos I, Liz-Marzán LM (2011) Nanostars shine bright for you: colloidal synthesis, properties and applications of branched metallic nanoparticles. Curr Opin Colloid Interface Sci 16:118–127

    Article  Google Scholar 

  5. De Cock LJ, De Koker S, De Geest BG, Grooten J, Vervaet C, Remon JP, Sukhorukov GB, Antipina MN (2010) Polymeric multilayer capsules in drug delivery. Angew Chem Int Ed 49:2–22

    Article  Google Scholar 

  6. De Geest BG, De Koker S, Sukhorukov GB, Kreft O, Parak WJ, Skirtach AG, Demeester J, De Smedt SC, Hennink WE (2009) Polyelectrolyte microcapsules for biomedical applications. Soft Matter 5:282–291

    Article  Google Scholar 

  7. Liu WJ, He GH, Qian Z (2011) Preparation of chitosan nanocapsules and their release properties. Polym Bull 67:1237–1244

    Article  CAS  Google Scholar 

  8. Cui J, Wang Y, Postma A, Hao J, Hosta-Rigau L, Caruso F (2010) Monodisperse polymer capsules: tailoring size, shell thickness, and hydrophobic cargo loading via emulsion templating. Adv Funct Mater 20:1625–1631

    Article  CAS  Google Scholar 

  9. Rossier-Miranda FJ, Schroën CG, Boom RM (2009) Colloidosomes: versatile microcapsules in perspective. Colloids Surf A 343:43–49

    Article  CAS  Google Scholar 

  10. Wagdare NA, Marcelis ATM, Boom RM, van Rijn CJM (2011) Microcapsules with a pH responsive polymer: influence of the encapsulated oil on the capsule morphology. Colloids Surf B 88:175–180

    Article  CAS  Google Scholar 

  11. Liu WJ, He GH, He ZC (2012) To prepare chitosan capsules via interfacial initiated chitosan macromonomer in situ polymerization. Polym Bull 68:1515–1524

    Article  CAS  Google Scholar 

  12. Caruso F, Caruso RA, Möhwald H (1998) Nanoengineering of inorganic and hybrid hollow spheres by colloidal templating. Science 282:1111–1114

    Article  CAS  Google Scholar 

  13. Peyratout CS, Dähne L (2004) Tailor-made polyelectrolyte microcapsules: from multilayers to smart containers. Angew Chem Int Ed 43:3762–3783

    Article  CAS  Google Scholar 

  14. Li XD, Zhang JX, Hu QL, Li XH (2011) From the 2-dimensional unstable polyelectrolyte multilayer to the 3-dimensional stable dry polyelectrolyte capsules. J Colloid Interface Sci 363:64–72

    CAS  Google Scholar 

  15. Mu B, Liu P, Pu QS (2010) A functional cross linked polymeric nanocapsule with pH-responsive brushes on its inner wall: preparation, characterization and controlled release. React Funct Polym 70:578–584

    Article  CAS  Google Scholar 

  16. Ochs CJ, Such GK, Yan Y, van Koeverden MP, Caruso F (2010) Biodegradable click capsules with engineered drug-loaded multilayers. ACS Nano 4(3):1653–1663

    Article  CAS  Google Scholar 

  17. Tang YF, Zhao YY, Li Y, Du YM (2010) A thermosensitive chitosan/poly(vinyl alcohol) hydrogel containing nanoparticles for drug delivery. Polym Bull 64:791–804

    Article  CAS  Google Scholar 

  18. Song BF, Zhang W, Peng R, Nie T, Li Y, Jiang Q, Gao R (2009) Synthesis and cell activity of novel galactosylated chitosan as a gene carrier. Colloid Surf B 70:181–186

    Article  CAS  Google Scholar 

  19. Gao JG, Zhang Y, Yu YF, Han YC, Zhang BZ, Gao CH (2011) Preparation of chitosan microspheres loading of 3,5-dihydroxy-4-i-propylstilbene and in vitro release. J Polym Res 18:1501–1508

    Article  CAS  Google Scholar 

  20. Szarpak A, Pignot-Paintrand I, Nicolas C, Picart C, Auzély-Velty R (2008) Multilayer assembly of hyaluronic acid/poly(allylamine): control of the buildup for the production of hollow capsules. Langmuir 24:9767–9774

    Article  CAS  Google Scholar 

  21. He GH, He ZC (2012) To prepared fluorescent chitosan capsules by in situ polyelectrolyte coacervation on poly(methacrylic acid)-doped porous calcium carbonate microparticles. Polym Bull 69:263–271

    Article  CAS  Google Scholar 

  22. Hiraku O, Yoshiharu M (1999) Biodegradation and distribution of water-soluble chitosan in mice. Biomaterials 20:175–182

    Article  Google Scholar 

  23. Cölfen H (2003) Precipitation of carbonates: recent progress in controlled production of complex shapes. Curr Opin Colloid Interface Sci 8:23–31

    Article  Google Scholar 

  24. Gregg SJ, Sing KS (1982) Adsorption, surface area and porosity, 2nd edn. Academic Press, New York, p 106

    Google Scholar 

  25. Chu LY, Park SH, Yamaguchi T, Nakao S (2001) Preparation of thermo-responsive core-shell microcapsules with a porous membrane and poly(N-isopropylacrylamide) gates. J Membr Sci 192:27–39

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. School of Architecture, Anhui University of Architecture, Hefei, 230022, Anhui, People’s Republic of China

    Liping Xu

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  1. Liping Xu
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Correspondence to Liping Xu.

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Xu, L. Sacrificial PSS-doped CaCO3 templates to prepare chitosan capsules and their deformation under bulk pressure. Polym. Bull. 70, 455–465 (2013). https://doi.org/10.1007/s00289-012-0811-1

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  • DOI: https://doi.org/10.1007/s00289-012-0811-1

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