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Anti-biofilm Effect of β-Lapachone and Lapachol Oxime Against Isolates of Staphylococcus aureus

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Abstract

Antimicrobial resistance in bacteria, such as Staphylococcus aureus, has been the subject of many assistance studies of alternatives for the treatment of infections. These studies aim to solve this problem for bacteria, such as biofilm formation. Aiming to control the emergence of the problem or enhance antibiotic activity, the data sources are inserted into new therapeutic alternatives for the treatment of infections. β-Lapachone and Lapachol Oxime are semi-synthetic derivatives of Lapachol with antimicrobial potential. Clinical isolates from human blood cultures were used in this study. Scanning electron microscopy (SEM) was performed following the glutaraldehyde fixation protocol. The presence of β-Lapachone and Lapachol Oxima interfered in the biofilm formation state. In the MEV, the effect was observed in the reduction of the population of biofilm-forming cells. Therefore, it was possible to conclude the promising potential of the anti-biofilm of substances, justifying the nature of the natural products as agents of inspiration for the detection of new compounds with the biological function.

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Acknowledgements

To CAPES (Higher Education Personnel Improvement Coordination) and FACEPE (Foundation for Science and Technology of Pernambuco) by granting the scholarship and research, aiming to stimulate the formation of high-level resources and standards of excellence indispensable to the development of our country.

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Authors and Affiliations

  1. Programa de Recursos Naturais do Semiárido – PgRNS of Federal University of São Francisco Valley, Petrolina, Brazil

    Antônio Wilton Cavalcante Fernandes

  2. Pharmacy da Federal, University of São Francisco Valley, Petrolina, Brazil

    Victória Laysna dos Anjos Santos

  3. Collegiate Pharmaceutical Sciences da Federal University of São Francisco Valley, Petrolina, Brazil

    Cleônia Roberta Melo Araújo

  4. Federal University of São Francisco Valley, Petrolina, Brazil

    Helinando Pequeno de Oliveira & Mateus Matiuzzi da Costa

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  1. Antônio Wilton Cavalcante Fernandes
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  2. Victória Laysna dos Anjos Santos
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  3. Cleônia Roberta Melo Araújo
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  4. Helinando Pequeno de Oliveira
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  5. Mateus Matiuzzi da Costa
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Correspondence to Antônio Wilton Cavalcante Fernandes.

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Fernandes, A.W.C., dos Anjos Santos, V.L., Araújo, C.R.M. et al. Anti-biofilm Effect of β-Lapachone and Lapachol Oxime Against Isolates of Staphylococcus aureus. Curr Microbiol 77, 204–209 (2020). https://doi.org/10.1007/s00284-019-01818-1

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  • DOI: https://doi.org/10.1007/s00284-019-01818-1

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