Abstract
IL-17-producing T helper (Th17) cells have been implicated in the pathogenesis of many inflammatory and autoimmune diseases. Targeting the effector cytokines IL-17 and GM-CSF secreted by autoimmune Th17 cells has been shown to be effective for the treatment of the diseases. Understanding a molecular basis of Th17 differentiation and effector functions is therefore critical for the regulation of the pathogenicity of tissue Th17 cells in chronic inflammation. Here, we discuss the roles of proinflammatory cytokines and environmental stimuli in the control of Th17 differentiation and chronic tissue inflammation by pathogenic Th17 cells in humans and in mouse models of autoimmune diseases. We also highlight recent advances in the regulation of pathogenic Th17 cells by gut microbiota and immunometabolism in autoimmune arthritis.
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Change history
29 April 2019
Unfortunately, an error occurred in the following passus of the article. The word “receptor” was missing in the sentence “Because T cells do not express GM-CSF receptor [41], GM-CSF affects non-T cells.”
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This work was supported by the JSPS Grants-in-Aid for Scientific Research (K.H.).
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This article is a contribution to the special issue on The Pathogenicity of Acquired Immunity in Human Diseases - Guest Editor: Kiyoshi Hirahara
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The original version of this article was revised: The word “receptor” was missing in the sentence “Because T cells do not express GM-CSF receptor [41], GM-CSF affects non-T cells.” . Full information regarding the corrections made can be found in the erratum/correction for this article.
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Yasuda, K., Takeuchi, Y. & Hirota, K. The pathogenicity of Th17 cells in autoimmune diseases. Semin Immunopathol 41, 283–297 (2019). https://doi.org/10.1007/s00281-019-00733-8
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DOI: https://doi.org/10.1007/s00281-019-00733-8