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Evidenzbasierte Psychotherapie der Panikstörung mit und ohne Agoraphobie

Überblick zur S1-Leitlinie der Deutschen Gesellschaft für Psychologie

Evidence-based psychotherapy of panic disorder with or without agoraphobia

Overview of the S1 guidelines of the German Society of Psychology

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Zusammenfassung

Bei den beiden Angststörungen Panikstörung und Agoraphobie handelt es sich um klinisch hoch prävalente Störungsbilder, die trotz nachgewiesenermaßen effektiver Behandlungsmöglichkeiten nach wie vor häufig nicht angemessen therapiert werden, obwohl zu deren psychotherapeutischer Behandlung inzwischen zahlreiche gute empirische Studien vorliegen. Die Qualität der vorliegenden Studien erlaubte die Erstellung der in diesem Beitrag vorgestellten Leitlinie [Heinrichs et al. (2009) Evidenzbasierte Leitlinie zur Psychotherapie der Panikstörung mit und ohne Agoraphobie. Hogrefe, Göttingen]. Diese Leitlinie verfolgt verschiedene Ziele auf unterschiedlichen Ebenen: Auf der Ebene der betroffenen Patienten sollen Verbesserungen des Erkrankungsverlaufs, des Funktionsniveaus und der Lebenszufriedenheit erreicht werden. Der behandelnde Therapeut soll Unterstützung in der Auswahl diagnostischer Instrumente und spezifisch wirksamer Maßnahmen erfahren, und auf der strukturellen Ebene des Versorgungsnetzes soll eine Optimierung von Versorgungsabläufen erzielt werden. Empfehlungen zur Therapie der Panikstörung mit und ohne Agoraphobie sowie der Agoraphobie ohne Panikstörung können überwiegend für die kognitive Verhaltenstherapie ausgesprochen werden.

Abstract

From the evidence reported in the recent guidelines [Heinrichs et al. (2009) Evidenzbasierte Leitlinie zur Psychotherapie der Panikstörung mit und ohne Agoraphobie. Hogrefe, Göttingen] the following conclusions can be drawn with respect to the treatment of panic disorder with or without agoraphobia, as well as for agoraphobia without panic disorder:

  1. 1.

    Every psychotherapy should be preceded by suitable diagnostics and a case formulation.

  2. 2.

    The effectiveness of every psychotherapy should be evaluated with well established measures.

  3. 3.

    For the treatment of panic disorder without agoraphobia, cognitive behavioral treatment (CBT) and applied relaxation have been shown to be effective (evidence grade 1).

  4. 4.

    For panic disorder with agoraphobia, CBT, combination treatment (CBT plus medication), as well as panic-focused psychodynamic psychotherapy in the outpatient setting have shown short-term effectiveness (evidence grade 1). Longer lasting effects have been documented for CBT (evidence grade 1).

  5. 5.

    For agoraphobia without panic disorder, CBT with a focus on situational exposure can be recommended (evidence grade 1).

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Literatur

  • Alpers GW, Pauli P (2001) Angstsensitivitäts-Index. PsychScience, Würzburg

  • Antony MM, Ledley DR, Liss A, Swinson RP (2006) Responses to symptom induction exercises in panic disorder. Behav Res Ther 44:85–98

    Article  PubMed  Google Scholar 

  • American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders – DSM-IV, 4. Aufl. American Psychiatric Association, Washington DC

  • American Psychological Association (1995) Template for developing guidelines: interventions for mental disorders and psychosocial aspects of physical disorders. American Psychological Association, Washington DC

  • Arntz A (2002) Cognitive therapy versus interoceptive exposure as treatment of panic disorder without agoraphobia. Behav Res Ther 40:325–441

    Article  PubMed  Google Scholar 

  • Arntz A, Hout M van den (1996) Psychological treatments of panic disorder without agoraphobia: cognitive therapy versus applied relaxation. Behav Res Ther 34:113–121

    Article  PubMed  Google Scholar 

  • Bakker A, Spinhoven P, Balkom AJ van, Dyck R van (2002) Relevance of assessment of cognitions during panic attacks in the treatment of panic disorder. Psychother Psychosom 71:158–161

    Article  PubMed  Google Scholar 

  • Bakker A, Balkom AJLM van, Spinhoven P et al (1998) Follow-up on the treatment of panic disorder with or without agoraphobia: a quantitative review. J Nerv Ment Dis 186:414–419

    Article  PubMed  Google Scholar 

  • Bandelow B (1996) Panik- und Agoraphobie-Skala (PAS). Hogrefe, Göttingen

  • Barlow DH, Gorman JM, Shear MK, Woods SW (2000) Cognitive-behavioral therapy, imipramine, or their combination for panic disorder: a randomized controlled trial. JAMA 283:2529–2536

    Article  PubMed  Google Scholar 

  • Biedermann J, Faraone SV, Hirshfeld-Becker DR et al (2001) Patterns of psychopathology and dysfunction in high-risk children of parents with panic disorder and major depression. Am J Psychiatry 158:49–57

    Article  Google Scholar 

  • Bouton ME, Mineka S, Barlow DH (2001) A modern learning theory perspective on the etiology of panic disorder. Psychol Rev 108:4–32

    Article  PubMed  Google Scholar 

  • Carter MM, Sbrocco T, Gore KL et al (2003) Cognitive-behavioral group therapy versus a wait-list control in the treatment of African American women with panic disorder. Cognit Ther Res 27:505

    Article  Google Scholar 

  • Chambless DL, Hollon S (1998) Defining empirically supported therapies. J Consult Clin Psychol 66:7–18

    Article  PubMed  Google Scholar 

  • Chambless DL, Ollendick TH (2001) Empirically supported psychological interventions: controversies and evidence. Annu Rev Psychol 52:685–716

    Article  PubMed  Google Scholar 

  • Clark DM, Salkovskis PM, Hackmann A, Middleton H (1994) A comparison of cognitive therapy, applied relaxation and imipramine in the treatment of panic disorder. Br J Psychiatry 164:759

    Article  PubMed  Google Scholar 

  • Clum GA, Clum GA, Surls R (1993) A meta-analysis of treatments for panic disorder. J Consult Clin Psychol 61:317–326

    Article  PubMed  Google Scholar 

  • Cox BJ, Endler NS, Lee PS, Swinson RP (1992) A meta-analysis of treatments for panic disorder with agoraphobia: imipramine, alprazolam, and in vivo exposure. J Behav Ther Exp Psychiatry 23:175–182

    Article  PubMed  Google Scholar 

  • Craske MG, Barlow DH, Meadows EA (2000) Mastery of your anxiety and panic: therapist guide to anxiety, panic, and agoraphobia. Harcourt Brace, San Antonio TX

  • Dannon PN, Gon-Usishkin M, Gelbert A et al (2004) Cognitive behavioral group therapy in panic disorder patients: the efficacy of CBGT versus drug treatment. Ann Clin Psychiatry 16:41–46

    Article  PubMed  Google Scholar 

  • Dengler W, Selbmann HK (Hrsg) (2000) Leitlinien zur Diagnostik und Therapie von Angsterkrankungen. Steinkopff, Darmstadt

  • De Rubeis RJ, Crits-Christoph P (1998) Empirically supported individual and group psychological treatments for adult mental disorders. J Consult Clin Psychol 66:37–52

    Article  Google Scholar 

  • Dreessen L, Arntz A, Luttels C, Sallaerts S (1994) Personality disorders do not influence the results of cognitive behavior therapies for anxiety disorders. Compr Psychiatry 35:265–274

    Article  PubMed  Google Scholar 

  • Ehlers A, Margraf J (1993) Fragebogen zu körperbezogenen Ängsten, Kognitionen und Vermeidung (AKV). Beltz Test, Weinheim

  • Emmelkamp PMG, Kuipers AC, Eggeraat JB (1978) Cognitive modification versus prolonged exposure in vivo: a comparison with agoraphobics as subjects. Behav Res Ther 16:33–41

    Article  PubMed  Google Scholar 

  • Fava GA, Savron G, Zielezny M et al (1997) Overcoming resistance to exposure in panic disorder with agoraphobia. Acta Psychiatr Scand 95:306–312

    Article  PubMed  Google Scholar 

  • Furukawa TA, Watanabe N, Churchill R (2006) Psychotherapy plus antidepressant for panic disorder with or without agoraphobia — systematic review. Br J Psychiatry 188:305–312

    Article  PubMed  Google Scholar 

  • Godemann F, Schabowska A, Naetebusch B et al (2006) The impact of cognitions on the development of panic and somatoform disorders: a prospective study in patients with vestibular neuritis. Psychol Med 36:99–108

    Article  PubMed  Google Scholar 

  • Gould RA, Otto MW, Pollack MH (1995) A meta-analysis of treatment outcome for panic disorder. Clin Psychol Rev 15(8):819–844

    Article  Google Scholar 

  • Gräfe K, Zipfel S, Herzog W, Löwe B (2004) Screening psychischer Störungen mit dem „Gesundheitsfragebogen für Patienten (PHQ-D)“. Diagnostica 50:171–181

    Article  Google Scholar 

  • Hahlweg K, Fiegenbaum W, Schröder B et al (2004) Klinische Brauchbarkeit der Konfrontationstherapie für Agoraphobische Patienten: Einfluss von syndromaler Komorbidität und therapeutischer Erfahrung. Z Klin Psychol Psychother Forsch Prax 33:130-138

    Article  Google Scholar 

  • Hayward C, Killen JD, Kraemer HC, Taylor CB (2000) Predictors of panic attacks in adolescents. J Am Acad Child Adolesc Psychiatry 39:207–214

    Article  PubMed  Google Scholar 

  • Heinrichs N, Alpers GW, Gerlach AL (2009) Evidenzbasierte Leitlinie zur Psychotherapie der Panikstörung mit und ohne Agoraphobie. Hogrefe, Göttingen

  • Heldt E, Manfro GG, Kipper L et al (2006) One-year follow-up of pharmacotherapy-resistant patients with panic disorder treated with cognitive-behavior therapy: outcome and predictors of remission. Behav Res Ther 44:657–665

    Article  PubMed  Google Scholar 

  • Hoffart A, Hedley LM (1997) Personality traits among panic disorder with agoraphobia patients before and after symptom-focused treatment. J Anxiety Disord 11:77–87

    Article  PubMed  Google Scholar 

  • Hoffart A, Martinsen EW (1990) Exposure-based integrated vs pure psychodynamic treatment of agoraphobic inpatients. Psychotherapy 27:210–218

    Article  Google Scholar 

  • Hofmann SG, Alpers GW, Pauli P (2008) Phenomenology of panic disorder, social anxiety disorder, and specific phobia. In: Antony MM, Stein MB (Hrsg) Oxford handbook of anxiety and related disorders. Oxford University Press, New York, S 34–46

  • Hoyer J, Margraf J (2003) Angstdiagnostik. Springer, Berlin Heidelberg New York Tokio

  • Jacobi F, Wittchen HU, Holting C et al (2004) Prevalence, co-morbidity and correlates of mental disorders in the general population: results from the German health interview and examination survey (GHS). Psychol Med 34:597–611

    Article  PubMed  Google Scholar 

  • Kenardy JA, Dow MG, Johnston DW et al (2003) A comparison of delivery methods of cognitive-behavioral therapy for panic disorder: an international multicenter trial. J Consult Clin Psychol 71:1068–1075

    Article  PubMed  Google Scholar 

  • Kendler KS, Neale MC, Kessler RC et al (1992) The genetic epidemiology of phobias in women. The interrelationship of agoraphobia, social phobia, situational phobia, and simple phobia. Arch Gen Psychiatry 49:273–281

    PubMed  Google Scholar 

  • Kessler RC, Chiu WT, Jin R et al (2006) The epidemiology of panic attacks, panic disorder, and agoraphobia in the National Comorbidity Survey Replication. Arch Gen Psychiatry 63:415–424

    Article  PubMed  Google Scholar 

  • Klerman GL, Weissman MM, Ouellette R et al (1991) Panic attacks in the community. Social morbidity and health care utilization. JAMA 265:742–746

    Article  PubMed  Google Scholar 

  • Leichsenring F (2002) Die Wirksamkeit tiefenpsychologisch fundierter und psychodynamischer Therapie. Eine Übersicht unter Berücksichtigung von Kriterien der Evidence-Based Medicine. Z Psychosom Med Psychother 48:139–162

    PubMed  Google Scholar 

  • Leichsenring F, Rabung S, Leibing E (2004) The efficacy of short-term psychodynamic psychotherapy in specific psychiatric disorders: a meta-analysis. Arch Gen Psychiatry 61:1208–1216

    Article  PubMed  Google Scholar 

  • LeLorier J, Gregoire G, Benhaddad A et al (1997) Discrepancies between meta-analyses and subsequent large randomized, controlled trials. N Engl J Med 337:536–542

    Article  PubMed  Google Scholar 

  • Löwe B, Spitzer RL, Zipfel S, Herzog W (2001) Gesundheitsfragebogen für Patienten (PHQ-D) Komplettversion und Kurzform. Testmappe mit Manual, Fragebögen, Schablonen. Pfizer GmbH, Karlsruhe

  • Marchand A, Dion MH (1998) L’impact de différents niveaux d’anxiété sociale sur l’efficacité d’un traitement cognitivo-comportemental du trouble panique avec agoraphobie. Sante ment Que 23:171–96

    PubMed  Google Scholar 

  • Margraf J, Margraf B (1997) Empfehlungen für die Verwendung von Meßinstrumenten in der klinischen Angstforschung. Z Klin Psychol 26:150–156

    Google Scholar 

  • Margraf J, Barlow DH, Clark DM, Telch MJ (1993) Psychological treatment of panic – work in progress on outcome, active ingredients, and follow-up. Behav Res Ther 31:1–8

    Article  PubMed  Google Scholar 

  • Margraf J, Poldrack A (2000) Angstsyndrome in Ost- und Westdeutschland: Eine repräsentative Bevölkerungserhebung. Z Klin Psychol Psychother 29(3):157–169

    Article  Google Scholar 

  • Margraf J, Schneider S (1990) Panik. Angstanfälle und ihre Behandlung, 2. Aufl. Springer, Berlin

  • Martinsen EW, Olsen T, Tonset E et al (1998) Cognitive-behavioral group therapy for panic disorder in the general clinical setting: a naturalistic study with 1-year follow-up. J Clin Psychiatry 59:437–442

    Article  PubMed  Google Scholar 

  • McLean PD, Woody S, Taylor S, Koch WJ (1998) Comorbid panic disorder and major depression: implications for cognitive-behavioral therapy. J Consult Clin Psychol 66:240–247

    Article  PubMed  Google Scholar 

  • Meyer C, Rumpf HJ, Hapke U et al (1998) Lebenszeitprävalenz psychischer Störungen in der erwachsenen Allgemeinbevölkerung. Nervenarzt 71:535–542

    Article  Google Scholar 

  • Milrod B, Busch F, Cooper A et al (1997) Manual of panic-focused psychodynamic psychotherapy. American Psychiatric Press, Washington DC

  • Milrod B, Leon AC, Busch F et al (2007) A randomized controlled clinical trial of psychoanalytic psychotherapy for panic disorder. Am J Psychiatry 164:265–272

    Article  PubMed  Google Scholar 

  • Mitte K (2005) A meta-analysis of the efficacy of psycho- and pharmacotherapy in panic disorder with and without agoraphobia. J Affect Disord 88:27–45

    Article  PubMed  Google Scholar 

  • Park JM, Mataix-Cols D, Marks IM et al (2001) Two-year follow-up after a randomised controlled trial of self- and clinician-accompanied exposure for phobia/panic disorders. Br J Psychiatry 178:543–548

    Article  PubMed  Google Scholar 

  • Peterson RA, Reiss S (1987) Anxiety sensitivity index manual. International Diagnostic Systems, Palos Heights IL

  • Reiss S, McNally RJ (1985) The expectancy model of fear. In: Reiss S, Bootzin RR (Hrsg) Theoretical issues in behavior therapy. Academic Press, San Diego, S 107–122

  • Reiss S, Peterson RA, Gursky DM, McNally RJ (1986) Anxiety sensitivity, anxiety frequency and the prediction of fearfulness. Behav Res Ther 24:1–8

    Article  PubMed  Google Scholar 

  • Rief W, Trenkamp S, Auer C, Fichter MM (2000) Cognitive behavior therapy in panic disorder and comorbid major depression. A naturalistic study. Psychother Psychosom 69:70–78

    Article  PubMed  Google Scholar 

  • Royal Australian and New Zealand College of Psychiatrists Clinical Practice. Guidelines Team for Panic Disorder and Agoraphobia (2003) Australian and New Zealand clinical practice guidelines for the treatment of panic disorder and agoraphobia. Aust N Z J Psychiatry 37:641–656

    Google Scholar 

  • Ruhmland M, Margraf J (2001) Effektivität psychologischer Therapien von generalisierter Angststörung und sozialer Phobie: Meta-Analysen auf Störungsebene. Verhaltenstherapie 11:27–40

    Article  Google Scholar 

  • Saß H, Wittchen HU, Zaudig M, Houben I (2003) DSM-IV-TR: Diagnostisches und statistisches Manual Psychischer Störungen – Textrevision. Hogrefe, Göttingen

  • Schneider S, Margraf J (2008) Panik: Angstanfälle und ihre Behandlung, 3. Aufl. Springer, Berlin

  • Schneider S, Margraf J (2006) Diagnostisches Interview bei psychischen Störungen (DIPS für DSM-IV-TR). Springer, Berlin

  • Schneider S, Margraf J (1998) Agoraphobie und Panikstörung. Reihe: Fortschritte der Psychotherapie – Bd. 3. Hogrefe

  • Teusch L, Böhme H, Gastpar M (1997) The benefit of an insight-oriented and experiential approach on panic and agoraphobia symptoms: Results of a controlled comparison of client-centered therapy and a combination with behavioral exposure. Psychother Psychosom 66:293–301

    Article  PubMed  Google Scholar 

  • Teusch L, Finke J (1995) Die Grundlagen eines Manuals für die gesprächspsychotherapeutische Behandlung bei Panik und Agoraphobie. Psychotherapeut 40:88–95

    Google Scholar 

  • Tsao JCI, Lewin MR, Craske MG (1998) The effects of cognitive-behavior therapy for panic disorder on comorbid conditions. J Anxiety Disord 12:357–371

    Article  PubMed  Google Scholar 

  • Van Balkom AJLM, Bakker A, Spinhoven P et al (1997) A meta-analysis of the treatment of panic disorder with or without agoraphobia: a comparison of psychopharmacological, cognitive-behavioral, and combination treatments. J Nerv Ment Dis 185:510–516

    Article  Google Scholar 

  • Westen D, Morrison K (2001) A multidimensional meta-analysis of treatments for depression, panic, and generalized anxiety disorder: an empirical examination of the status of empirically supported therapies. J Consult Clin Psychol 69:875–899

    Article  PubMed  Google Scholar 

  • Wiborg IM, Dahl AA (1996) Does brief dynamic psychotherapy reduce the relapse rate of panic disorder? Arch Gen Psychiatry 53:689–694

    PubMed  Google Scholar 

  • Wittchen HU, Essau CA, Krieg JC (1991) Anxiety disorders – similarities and differences of comorbidity in treated and untreated groups. Br J Psychiatry 159:23–33

    Article  Google Scholar 

  • Wittchen HU, Zaudig M, Fydrich T (1997) SKID – Strukturiertes Klinisches Interview für DSM-IV Achse I und II. Hogrefe, Göttingen

  • World Health Organization (1992) International statistical classification of diseases and related health problems, 10th revision (ICD-10), 2. Aufl. WHO, Geneva

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Correspondence to Georg W. Alpers.

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Diese Zusammenfassung kann nur einen Überblick über Entstehung und Bestandteile der Leitlinie geben und hat nicht zum Ziel, die gründliche Lektüre der ausführlicheren Leitlinie zu ersetzen. Dort finden sich die Daten und Literaturangaben, die hier nur in übersichtlicher Form zusammengefasst werden (Heinrichs et al. 2009).

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Alpers, G., Gerlach, A. & Heinrichs, N. Evidenzbasierte Psychotherapie der Panikstörung mit und ohne Agoraphobie. Psychotherapeut 56, 535–548 (2011). https://doi.org/10.1007/s00278-011-0864-x

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