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Falsely elevated serum vitamin B12 levels in a case of pernicious anemia

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References

  1. Stabler SP. Vitamin B12 deficiency. N Engl J Med [Internet]. 2013 Jan 10;368(2):149–60. Available from: https://doi.org/10.1056/NEJMcp1113996

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  3. Devalia V, Hamilton MS, Molloy AM. Guidelines for the diagnosis and treatment of cobalamin and folate disorders. Br J Haematol [Internet]. 2014 Aug 1;166(4):496–513. Available from: https://doi.org/10.1111/bjh.12959

  4. Shipton MJ, Thachil J. Vitamin B12 deficiency – a 21st century perspective. Clin Med (Lond) [Internet]. 2015 Apr 1;15(2):145–150. Available from: https://doi.org/10.7861/clinmedicine.15-2-145

  5. Devalia V. Diagnosing vitamin B-12 deficiency on the basis of serum B-12 assay. BMJ [Internet]. 2006 Aug 17;333(7564):385–386. Available from: https://doi.org/10.1136/bmj.333.7564.385

  6. Moridani M, Ben-Poorat S. Laboratory investigation of vitamin B12 deficiency. Lab Med [Internet]. 2006 Mar 1;37(3):166–74. Available from: https://doi.org/10.1309/CVHKLE2R4W68K2NQ

  7. Carmel R, Agrawal YP. Failures of cobalamin assays in pernicious anemia. N Engl J Med [Internet]. 2012 Jul 25;367(4):385–6. Available from: https://doi.org/10.1056/NEJMc1204070

  8. Yang DT, Cook RJ. Spurious elevations of vitamin B12 with pernicious anemia. N Engl J Med [Internet]. 2012 May 2;366(18):1742–3. Available from: https://doi.org/10.1056/NEJMc1201655

  9. Oo TH. Diagnostic difficulties in pernicious anemia. Discov Med [Internet]. 2019 Dec 23;28(155):247–253. Available from: https://www.discoverymedicine.com/Thein-H-Oo/2019/12/diagnostic-difficulties-in-pernicious-anemia/

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Authors and Affiliations

  1. Department of Haematology-Oncology, National University Cancer Institute, Singapore, National University Health System, 5 Lower Kent Ridge Rd, 119074, Singapore, Singapore

    Edwin W. S. Thong, Yen-Lin Chee & Wei-Ying Jen

  2. Department of Laboratory Medicine, National University Hospital, National University Health System, 5 Lower Kent Ridge Rd, 119074, Singapore, Singapore

    Shaun S. Tan & Sunil K. Sethi

Authors
  1. Edwin W. S. Thong
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  2. Shaun S. Tan
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  3. Sunil K. Sethi
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  4. Yen-Lin Chee
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  5. Wei-Ying Jen
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Contributions

All authors contributed to the writing of the paper. ET was the lead author of the case report. ET, WJ, and YC were the physicians managing the patient during his hospital admission. WJ and YC reviewed the patient’s peripheral blood film. ST and SS performed the polyethylene glycol treatment on the patient’s serum sample as described in the protocol by Merrigan et al. [2], and provided expertise in the laboratory aspect of the case report. SS and YC revised the paper critically.

Corresponding author

Correspondence to Edwin W. S. Thong.

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Thong, E.W.S., Tan, S.S., Sethi, S.K. et al. Falsely elevated serum vitamin B12 levels in a case of pernicious anemia. Ann Hematol 101, 889–892 (2022). https://doi.org/10.1007/s00277-021-04612-x

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  • DOI: https://doi.org/10.1007/s00277-021-04612-x

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