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Course of colonization by multidrug-resistant organisms after allogeneic hematopoietic cell transplantation

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Abstract

Multidrug-resistant organisms (MDRO) have been developing as an emerging problem in allogeneic hematopoietic cell transplantation (HCT). Since no data are available on the course of MDRO colonization after HCT, we investigated in this retrospective, single-center study, persistence and clearance of MDRO after HCT. From June 2010 to December 2015, 121 consecutive HCT patients were included. Patients received a MDRO screening before conditioning as well as surveillance cultures after HCT. In MDRO-colonized patients, surveillance specimens were taken until MDRO were no longer detectable. Thirty-three patients (27%) were found to be colonized by at least one MDRO at any time point until day 100 post HCT. Day 100 (2-year) non-relapse mortality (NRM) and overall survival (OS) of MDRO-colonized (MDRO+) versus non-colonized (MDRO−) patients were essentially the same. NRM is 15% (21%) versus 15% (24%). Two-year OS is 60 versus 55% for MDRO+ versus MDRO− patients. Out of the 33 MDRO+ patients, 21 cleared the MDRO. Median time to non-detectability of MDRO was 6 months. In 12 patients, the MDRO persisted. There was a significant (p < 0.0001) survival difference between patients who cleared the MDRO versus those with MDRO persistence (2-year OS 80 vs 40%). Except for the length of antibiotic therapy as a potential risk factor for MDRO persistence after HCT, no other conventional factors could be identified. (a) colonization by MDRO per se had no negative impact on the outcome, (b) MDRO can be cleared by the majority of patients after allogeneic HCT, and (c) to increase the probability to clear MDRO, the use of antibiotics in MDRO+ patients should be reviewed critically.

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Funding

This work was supported by the Alfred und Angelika Gutermuth-Stiftung.

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Authors and Affiliations

  1. Universitätsmedizin Mannheim, III. Medizinische Klinik, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany

    D. Heidenreich, S. Kreil, M. Jawhar, N. Müller, F. Nolte, W.-K. Hofmann & Stefan A. Klein

  2. Institut für Medizinische Mikrobiologie und Hygiene, Universitätsmedizin Mannheim, Mannheim, Germany

    K-P. Becker & T. Miethke

Authors
  1. D. Heidenreich
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  2. S. Kreil
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  3. M. Jawhar
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  4. N. Müller
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  5. F. Nolte
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  6. K-P. Becker
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  7. T. Miethke
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  8. W.-K. Hofmann
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  9. Stefan A. Klein
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Correspondence to Stefan A. Klein.

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All procedures were performed in accordance with the ethical standards of the responsible committee on human experimentation and with the Helsinki Declaration of 1964, as revised in 2013.

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The authors declare that they have no conflict of interest.

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Heidenreich, D., Kreil, S., Jawhar, M. et al. Course of colonization by multidrug-resistant organisms after allogeneic hematopoietic cell transplantation. Ann Hematol 97, 2501–2508 (2018). https://doi.org/10.1007/s00277-018-3475-6

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  • DOI: https://doi.org/10.1007/s00277-018-3475-6

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