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Outcome of allogeneic hematopoietic stem cell transplantation in adult patients with acute myeloid leukemia harboring trisomy 8

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Abstract

Trisomy 8 (+8) is one of the most common cytogenetic abnormalities in adult patients with acute myeloid leukemia (AML). However, the outcome of allogeneic hematopoietic stem cell transplantation (HSCT) in adult patients with AML harboring +8 remains unclear. To evaluate, the outcome and prognostic factors in patients with AML harboring +8 as the only chromosomal abnormality or in association with other abnormalities, we retrospectively analyzed the Japanese registration data of 631 adult patients with AML harboring +8 treated with allogeneic HSCT between 1990 and 2013. In total, 388 (61%) patients were not in remission at the time of HSCT. With a median follow-up of 38.5 months, the probability of overall survival and the cumulative incidence of relapse at 3 years were 40 and 34%, respectively. In the multivariate analysis, two or more additional cytogenetic abnormalities and not being in remission at the time of HSCT were significantly associated with a higher overall mortality and relapse. Nevertheless, no significant impact on the outcome was observed in cases with one cytogenetic abnormality in addition to +8. Although more than 60% of the patients received HSCT when not in remission, allogeneic HSCT offered a curative option for adult patients with AML harboring +8.

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Acknowledgments

We thank all of the physicians and staff at the centers who provided the clinical data to the Transplant Registry Unified Management Program (TRUMP) of the Japan Society of Hematopoietic Cell Transplantation (JSHCT). This work was supported in part by a Research Grant for Allergic Disease and Immunology from the Japanese Ministry of Health, Labor, and Welfare.

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Authors and Affiliations

  1. Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan

    Takaaki Konuma

  2. Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

    Tadakazu Kondo

  3. Department of Hematology and Oncology, St Luke’s International University and Hospital, Tokyo, Japan

    Takuya Yamashita

  4. Department of Hematology, Toranomon Hospital, Tokyo, Japan

    Naoyuki Uchida

  5. Department of Hematopoietic Stem Cell Transplantation Division, National Cancer Center Hospital, Tokyo, Japan

    Takahiro Fukuda

  6. Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan

    Yukiyasu Ozawa

  7. Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan

    Kazuteru Ohashi

  8. Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan

    Hiroyasu Ogawa

  9. Department of Hematology, Meitetsu Hospital, Nagoya, Japan

    Chiaki Kato

  10. Division of Molecular Therapy, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

    Satoshi Takahashi

  11. Department of Hematology, Kanagawa Cancer Center, Kanagawa, Japan

    Heiwa Kanamori

  12. Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan

    Tetsuya Eto

  13. Department of Hematology, Chiba University Hospital, Chiba, Japan

    Chiaki Nakaseko

  14. Department of Hematology and Oncology, JA Aichi Konan Kosei Hospital, Konan, Japan

    Akio Kohno

  15. Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan

    Tatsuo Ichinohe

  16. Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan

    Yoshiko Atsuta

  17. Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Yoshiko Atsuta

  18. Division of Hematology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan

    Akiyoshi Takami

  19. Division of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan

    Shingo Yano

Authors
  1. Takaaki Konuma
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  2. Tadakazu Kondo
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  9. Chiaki Kato
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  14. Akio Kohno
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  15. Tatsuo Ichinohe
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  16. Yoshiko Atsuta
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  17. Akiyoshi Takami
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  18. Shingo Yano
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Adult Acute Myeloid Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation (JSHCT)

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Correspondence to Takaaki Konuma.

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Konuma, T., Kondo, T., Yamashita, T. et al. Outcome of allogeneic hematopoietic stem cell transplantation in adult patients with acute myeloid leukemia harboring trisomy 8. Ann Hematol 96, 469–478 (2017). https://doi.org/10.1007/s00277-016-2909-2

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  • DOI: https://doi.org/10.1007/s00277-016-2909-2

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