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Cytogenetic profiles of 2806 patients with acute myeloid leukemia—a retrospective multicenter nationwide study

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Abstract

The cytogenetic and molecular data is recognized as the most valuable prognostic factor in acute myeloid leukemia (AML). Our aim was to systemically analyze the cytogenetics of Korean AML patients and to compare the cytogenetic profiles of various races to identify possible geographic heterogeneity. We retrospectively reviewed medical records of 2806 AML patients diagnosed at 11 tertiary teaching hospitals in Korea between January 2007 and December 2011. The most common recurrent chromosomal abnormality was t(8;21) (8.8 %, 238/2717), but t(15;17) showed an almost same number (8.6 %,235/2717). Among de novo AML, the most frequent aberrations were t(15;17), observed in 229 (10.7 %). The most common French-American-British (FAB) classification type was M2 (32.2 %), and recurrent cytogenetic abnormalities correlated with the FAB subtypes. Among 283 secondary AML cases, myelodysplastic syndrome was the most common predisposing factor. About 67.1 % of the secondary AML cases were associated with chromosomal aberrations, and chromosome 7 abnormalities (n = 45, 15.9 %) were most common. The incidence of FLT3 internal tandem duplication mutation was relatively low at 15 %. Our study reports certain similarities and differences in comparison to previous reports. Such discrepancies call for extensive epidemiological studies to clarify the role of genetic as well as geographic heterogeneity in the pathogenesis of AML.

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Acknowledgments

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (NRF-2014R1A1A1002797).

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    Authors and Affiliations

    1. Department of Medicine, Kyung Hee University Graduate School, 23, Kyungheedae-ro, Dongdaemun-gu, Seoul, 130-872, Republic of Korea

      Ja Min Byun

    2. Department of Laboratory Medicine, School of Medicine, Kyung Hee University, 23, Kyungheedae-ro, Dongdaemun-gu, Seoul, 130-872, Republic of Korea

      Young Jin Kim & Tae Sung Park

    3. Department of Internal Medicine, School of Medicine, Kyung Hee University, 23, Kyungheedae-ro, Dongdaemun-gu, Seoul, 130-872, Republic of Korea

      Hwi-Joong Yoon & Si-Young Kim

    4. Department of Internal Medicine, Cancer Research Institute, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul, 137-701, Republic of Korea

      Hee-Je Kim, Jaeho Yoon & Woo-Sung Min

    5. Department of Internal Medicine, Yonsei University College of Medicine, Seodaemun-gu, Seoul, Republic of Korea

      Yoo Hong Min & Jun-Won Cheong

    6. Department of Internal Medicine, Gachon University Gil Medical Center, Seongnam-si, Republic of Korea

      Jinny Park & Jae Hoon Lee

    7. Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea

      Dae Sik Hong & Seong Kyu Park

    8. Department of Internal Medicine, Chonnam National University Hwasun Hospital, Hwasun, Republic of Korea

      Hyeoung-Joon Kim & Jae-Sook Ahn

    9. Department of Internal Medicine, Pusan National University School of Medicine, Busan, Republic of Korea

      Ho-Jin Shin & Joo Seop Chung

    10. Department of Internal Medicine, Inje University Busan Paik Hospital, Busan, Republic of Korea

      Won Sik Lee & Sang Min Lee

    11. Department of Internal Medicine, Korea University School of Medicine Anam Hospital, Seoul, Republic of Korea

      Yong Park & Byung Soo Kim

    12. Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

      Je-Hwan Lee & Kyoo-Hyung Lee

    13. Division of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

      Chul Won Jung & Jun Ho Jang

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    1. Ja Min Byun
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    on behalf of the AML/MDS working party of Korean Society of Hematology

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    Correspondence to Woo-Sung Min or Tae Sung Park.

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    This study was conducted according to the Declaration of Helsinki and was approved by the institutional review board of all the participating hospitals. In light of the retrospective nature of the study, informed consent was waived.

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    No conflict of interest to disclose.

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    Ja Min Byun and Young Jin Kim contributed equally to this work.

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    Byun, J.M., Kim, Y.J., Yoon, HJ. et al. Cytogenetic profiles of 2806 patients with acute myeloid leukemia—a retrospective multicenter nationwide study. Ann Hematol 95, 1223–1232 (2016). https://doi.org/10.1007/s00277-016-2691-1

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