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Alterations of CD43 expression in transfusion-dependent myelodysplastic syndromes

Annals of Hematology volume 85, pages 281–284 (2006)Cite this article

Abstract

CD43 is a sialylated glycoprotein expressed on the surface of most haemopoietic cells and has been implicated in cell adhesion and signaling. It has previously been shown that CD43 expression is altered in patients with myelodysplastic syndrome (MDS). This raised the question of whether the alteration is associated with transfusions in these patients. We studied the expression of this antigen on peripheral blood leucocytes in two groups of patients with refractory anaemia, 22 transfused and 20 non-transfused. We found decreased expression of CD43 on the monocytes and neutrophils of patients receiving transfusions. Other activation molecules were studied (CD11b, CD18) and were found up-regulated suggesting the existence of activated leucocytes in these patients. The increased levels of soluble vascular cellular endothelial molecule after transfusions in these patients suggested vascular endothelial activation in the absence of infection. Given together, these results show that decreased CD43 in the transfused group of MDS patients is associated with an activated endothelial phenotype.

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Authors and Affiliations

  1. Department of Hematology, University Hospital of Thessalia, Larissa, Greece

    E. Kyriakou & D. Kyriakou

  2. Department of Hematology, Venizelion General Hospital, Heraklion, Crete, Greece

    D. Liapi

  3. Department of Hematology, University Hospital of Crete, PO BOX 1352, Heraklion, Crete, Greece

    M. Niniraki & M. Alexandrakis

Authors
  1. E. Kyriakou
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  2. D. Kyriakou
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  3. D. Liapi
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  4. M. Niniraki
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  5. M. Alexandrakis
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Correspondence to M. Alexandrakis.

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Kyriakou, E., Kyriakou, D., Liapi, D. et al. Alterations of CD43 expression in transfusion-dependent myelodysplastic syndromes. Ann Hematol 85, 281–284 (2006). https://doi.org/10.1007/s00277-005-0011-2

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  • DOI: https://doi.org/10.1007/s00277-005-0011-2

Keywords

  • CD43
  • Myelodysplastic syndromes
  • Transfusion