Abstract
<p>18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) has been used as a potential tool for imaging nodal follicular lymphoma (FL) and extranodal spread. As primary intestinal FL is increasingly being recognized, we have performed a study to investigate the usefulness of 18F-FDG-PET for staging of extranodal FL within the gastrointestinal tract. In eight patients with a diagnosis of FL localized in the duodenum (six cases in stage I and one each in stages II and IV, respectively) whole body 18F-FDG-PET scans were performed. Seven patients with duodenal FL were rated WHO grade 1 and one had FL grade 3, while both patients with secondary spread had FL WHO grade 1. All patients were imaged before initiation of therapy. None of the patients with primary duodenal FL showed pathologically elevated 18F-FDG uptake. 18F-FDG-PET findings were not influenced by histological grade or proliferative activity of FL. These findings suggest that 18F-FDG-PET is not useful for clinical assessment of primary duodenal FL.
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Nathwani B, Harris N, Weisenburger D, et al. (2001) Follicular lymphoma. In: Jaffe ES, Harris NL, Stein H, Vardiman J (eds) World Health Organization classification of tumours: tumours of hematopoietic and lymphoid tissues. IARC Press, Lyon, pp 162–170
The Non-Hodgkin’s Lymphoma Classification Project (1997) A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin’s lymphoma. Blood 89:3909–3918
Ott G, Katzenberger T, Lohr A, et al. (2002) Cytomorphologic, immunohistochemical, and cytogenetic profiles of follicular lymphoma: 2 types of follicular lymphoma grade 3. Blood 99:3806–3812
Yoshino T, Miyake K, Ichimura K, et al. (2000) Increased incidence of follicular lymphoma in the duodenum. Am J Surg Pathol 24:688–693
Shia J, Teruya-Feldstein J, Pan D, et al. (2002) Primary follicular lymphoma of the gastrointestinal tract: a clinical and pathologic study of 26 cases. Am J Surg Pathol 26:216–223
Chott A, Raderer M, Jäger U, et al. (2001) Follicular lymphoma of the duodenum: a distinct extranodal B-cell lymphoma (abstract)? Mod Pathol 14:160
Czernin J, Phelbs ME (2002) Positron emission tomography scanning: current and future applications. Annu Rev Med 53:89–112
Jerusalem G, Beguin Y, Najjar F, et al. (2001) Positron emission tomography (PET) with 18F-fluorodeoxyglucose (18F-FDG) for the staging of low-grade non-Hodgkin’s lymphoma (NHL). Ann Oncol 12:825–830
Elstrom R, Guan L, Baker G, et al. (2003) Utility of FDG-PET scanning in lymphoma by WHO classification. Blood101:3875–3876
Hoffmann M, Kletter K, Diemling M, et al. (1999) F18-FDG-PET does not visualize extranodal B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) type. Ann Oncol 10:1185–1189
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Hoffmann, M., Chott, A., Püspök, A. et al. 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) does not visualize follicular lymphoma of the duodenum. Ann Hematol 83, 276–278 (2004). https://doi.org/10.1007/s00277-003-0827-6
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DOI: https://doi.org/10.1007/s00277-003-0827-6