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Primary gastric T-cell lymphoma not associated with human T-lymphotropic virus type I: a case report and review of the literature

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Abstract

Primary gastric T-cell lymphoma (PGTL) not associated with human T-lymphotropic virus type I (HTLV-I) is extremely rare and such a case is reported herein. The patient was a 58-year-old Japanese male presenting with submucosal tumor of the stomach identified on endoscopic examination. The lesion was diagnosed as non-Hodgkin's lymphoma by endoscopic biopsy and classified as peripheral T-cell lymphoma, unspecified, due to clonal rearrangement of the T-cell receptor β (TCR) gene and expression of TCRβ protein in the absence of B-cell genotypes and phenotypes. Unlike previously reported cases of HTLV-I-unassociated PGTL, lymphoma in the current case was characterized histologically as "low grade" and phenotypically as CD4+, TIA-1+, granzyme B+, and CD103−. The lymphoma responded well to chemotherapy and radiation, and the patient was well with no detectable disease 10 months after initiation of therapy. A review of patients with PGTL in the literature revealed a few long-term survivors, and the investigation of therapeutic strategies for PGTL is, therefore, necessary.

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Authors and Affiliations

  1. Department of Internal Medicine IV, Kitasato University School of Medicine, Kanagawa, Japan

    N. Niitsu, M. Kohri, S. Tanabe, R. Horie & M. Higashihara

  2. Department of Clinical and Laboratory Medicine, Wakayama Medical University, Wakayama, Japan

    H. Nakamine

  3. Department of Pathology, Saitama Medical Center, Saitama Medical School, Kawagoe, Japan

    J. Tamaru

  4. Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan

    K. Iwabuchi

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  1. N. Niitsu
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  2. H. Nakamine
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  3. M. Kohri
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  4. M. Hayama
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  5. J. Tamaru
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  6. K. Iwabuchi
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  7. S. Tanabe
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  8. R. Horie
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  9. M. Higashihara
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Correspondence to N. Niitsu.

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Niitsu, N., Nakamine, H., Kohri, M. et al. Primary gastric T-cell lymphoma not associated with human T-lymphotropic virus type I: a case report and review of the literature. Ann Hematol 82, 197–202 (2003). https://doi.org/10.1007/s00277-003-0612-6

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  • DOI: https://doi.org/10.1007/s00277-003-0612-6

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