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Incidence of thrombophilia detected in southern Taiwanese patients with venous thrombosis

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Abstract

In order to analyze the incidence of thrombophilia in southern Taiwan, we studied the prevalence of antithrombin (AT), protein C (PC), and protein S (PS) deficiencies, the prevalence of factor V Leiden mutation, and the presence of acquired lupus anticoagulant (LA) and anticardiolipin antibody (ACA) in 56 patients ≤65 years old with deep venous thrombosis (DVT). Of 56 patients, 30 were male, 26 female, and the mean age of the patients was 43 years (18–65 years). None had factor V mutation or activated PC resistance; 21 patients (37.5%) showed abnormal results: 4 (7.1%) had AT deficiencies, 6 (10.7%) PC deficiencies, 6 (10.7%) PS deficiencies, 2 (3.6%) a combined PC and PS deficiency, and 3 (5.4%) LA and ACA. Only PC and PS deficiencies were significantly associated with increased risk for the development of thrombosis with an odds ratio of 4.2 (95% confidence interval: 1.2–15.0, P=0.018) and 8.1 (95% confidence interval: 1.6–40.6, P=0.003), respectively. We concluded that the prevalence of heritable thrombophilia (34.0%) in Taiwan is higher than that in Western countries, but that it is lower than previously reported in Hong Kong and Taiwan. We attribute this to selection bias.

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References

  1. Hume M, Sevitt S, Thomas DP (1970) Venous thrombosis and pulmonary embolism. Harvard University Press, Cambridge, MA, pp 136–137

  2. Hirsh J, Genton E, Hull R (1981) Venous thromboembolism. Grune and Stratton, New York

  3. Vikydal R, Korninger C, Kyrle PA, Niessner H, Pabinger I, Thaler E, et al. (1985) The prevalence of hereditary antithrombin-III deficiency in patients with a history of venous thromboembolism. Thromb Haemost 54:744–745

    CAS  PubMed  Google Scholar 

  4. Gladson CL, Scharrer I, Hach V, Beck KH, Griffin JH (1988) The frequency of type I heterozygous protein S and protein C deficiency in 141 unrelated young patients with venous thrombosis. Thromb Haemost 59:18–22

    CAS  PubMed  Google Scholar 

  5. Heijboer H, Brandjes DP, Buller HR, Sturk A, ten Cate JW (1990) Deficiencies of coagulation-inhibiting and fibrinolytic proteins in outpatients with deep-vein thrombosis. N Engl J Med 323:1512–1516

    Article  CAS  PubMed  Google Scholar 

  6. Tobelem G, Cariou R, Cames A (1987) The lupus anticoagulant and its role in thrombosis. Blood Rev 1:21–24

    Article  CAS  PubMed  Google Scholar 

  7. Broekmans AW, van der Linden IK, Veltkamp JJ, Bertina RM (1983) Prevalence of isolated protein C deficiency in patients with venous thrombotic disease and in the population. Thromb Haemost 50:350

    Google Scholar 

  8. Briet E, Engesser L, Brommmer EJP, Broekmans AW, Bertina RM (1987) Thrombophilia: its causes and a rough estimate of its prevalence. (XIth International Congress on Thrombosis and Haemostasis) Thromb Haemost 58:39

    Google Scholar 

  9. Malm J, Laurell M, Nilsson IM, Dahlback B (1992) Thromboembolic disease—critical evaluation of laboratory investigation. Thromb Haemost 68:7–13

    CAS  PubMed  Google Scholar 

  10. Dahlback B, Carlsson M, Svensson PJ (1993) Familial thrombophilia due to a previous unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc Natl Acad Sci U S A 90:1004–1008

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Bertina RM, Koeleman BP, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, et al. (1994) Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 369:64–67

    Article  CAS  PubMed  Google Scholar 

  12. Griffin JH, Evatt B, Wideman C, Fernandez JA (1993) Anticoagulant protein C pathway defective in majority of thrombophilic patients. Blood 82:1989–1993

    CAS  PubMed  Google Scholar 

  13. Koster T, Rosendaal FR, de Ronde H, Briet E, Vandenbroucke JP, Bertina RM (1993) Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study. Lancet 342:1503–1506

    Article  CAS  PubMed  Google Scholar 

  14. Svensson PJ, Dahlback B (1994) Resistance to activated protein C as a basis for venous thrombosis. N Engl J Med 330:517-522

    Article  CAS  PubMed  Google Scholar 

  15. Liu HW, Kwong YL, Bourke C, Lam CK, Lie AKW, Wei D, et al. (1994) High incidence of thrombophilia detected in Chinese patients with venous thrombosis. Thromb Haemost 71:416–419

    CAS  PubMed  Google Scholar 

  16. Shen MC, Lin JS, Tsay W (1997) High prevalence of antithrombin III, protein C and protein S deficiency, but no factor V Leiden mutation in venous thrombophilic Chinese patients in Taiwan. Thromb Res 87:377–385

    Article  CAS  PubMed  Google Scholar 

  17. Triplett DA, Brandt JT, Kaczor D, Schaeffer J (1983) Laboratory diagnosis of lupus inhibitors: a comparison of the tissue thromboplastin inhibition procedure with a new platelet neutralization procedure. Am J Clin Pathol 79:678–682

    Article  CAS  PubMed  Google Scholar 

  18. Kirschbaum NE, Foster PA (1995) The polymerase chain reaction with sequence specific primers for the detection of the factor V mutation associated with activated protein C resistance. Thromb Haemost 74:874–878

    CAS  PubMed  Google Scholar 

  19. Shen MC, Lin JS, Tsay W (2000) Protein C and protein S deficiencies are the most important risk factors associated with thrombosis in Chinese venous thrombophilic patients in Taiwan. Thromb Res 99:447–452

    Article  CAS  PubMed  Google Scholar 

  20. Lane DA, Mannucci PM, Bauer KA, Bertina RM, Bochkov NP, Boulyjenkov V, et al. (1996) Inherited thrombophilia: part 1. Thromb Haemost 76:651–662

    CAS  PubMed  Google Scholar 

  21. Preda L, Tripodi A, Valsecchi C, Lombardi A, Finotto E, Mannucci PM (1990) A prothrombin time-based functional assay of protein S. Thromb Res 60:19–32

    Article  CAS  PubMed  Google Scholar 

  22. Faioni EM, Franchi F, Asti D, Sacchi E, Bernardi F, Mannucci PM (1993) Resistance to activated protein C in nine thrombophilic families: interference in a protein S functional assay. Thromb Haemost 70:1067–1071

    CAS  PubMed  Google Scholar 

  23. Van der Meer FJM, Koster T, Vandenbroucke JP, Briet E, Rosendaal FR (1997) The Leiden Thrombophilia Study (LETS). Thromb Haemost 78:631–635

    Google Scholar 

  24. Tait RC, Walker ID, Perry DJ, Islam SIAM, Daly ME, McCall F, et al. (1994) Prevalence of antithrombin deficiency in the healthy population. Br J Haematol 87:106–112

    Article  CAS  PubMed  Google Scholar 

  25. van Boven HH, Reitsma PH, Rosendaal FR, Bayston TA, Chowdhury V, Bauer KA, Scharrer I, Conard J, Lane DA (1996) Factor V Leiden (FV R506Q) in families with inherited antithrombin deficiency. Thromb Haemost 75:417–421

    Google Scholar 

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  1. Division of Hematology/Oncology, Department of Internal Medicine, National Cheng-Kung University Hospital, 138 Sheng-Li Road, 704, Tainan, Taiwan

    T.-Y. Chen, W.-C. Su & C.-J. Tsao

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  1. T.-Y. Chen
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  2. W.-C. Su
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  3. C.-J. Tsao
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Correspondence to T.-Y. Chen.

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Chen, TY., Su, WC. & Tsao, CJ. Incidence of thrombophilia detected in southern Taiwanese patients with venous thrombosis. Ann Hematol 82, 114–117 (2003). https://doi.org/10.1007/s00277-002-0603-z

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