Skip to main content

Advertisement

SpringerLink
Log in

Corpus callosum area and sectioning: a radioanatomical study correlated with MRI and cadaver morphometry

  • Original Article
  • Published:
Surgical and Radiologic Anatomy Aims and scope Submit manuscript

Abstract

Purpose

The corpus callosum (CC) is the primary interhemispheric connection between the two cerebral hemispheres. Besides their similar morphological characters, there are differences in their measurements. This study aimed to divide the CC into groups using planes based on the anterior commissure (AC) and posterior commissure (PC) and to detect differences in CC magnetic resonance imaging (MRI) and cadaver samples between these groups.

Methods

The study included 80 patients (40 male and 40 female patients) who underwent normal MRI in the midsagittal plane, and 38 cerebral hemispheres from 40 adult cadaver brains, with each hemisected in the midsagittal plane. The medial surface of the CC was divided vertically into three parts (the anterior, middle, and posterior zones) according to the AC and PC. Areas and parameters were measured in both the cadaveric hemispheres and patient MRI images.

Results

The total CC area and CC areas between, anterior, and posterior to the AC-PC vertical lines were the same in both the MRI and cadaver samples. In addition, morphometric measurements like the CC length, AC-PC length, and CC height at the AC and PC vertical lines, and their correlations were also found to be similar between the MRI and cadaver samples.

Conclusion

This study proposes three areas according to AC and PC classification (anterior, middle, and posterior). This new proposed classification is suitable for stereotactic interventions and is useful for obtaining data from MRI images. However, it should be kept in mind that there may be changes and variations.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

References

  1. Aboitiz F, Scheibel AB, Fisher RS, Zaidel E (1992) Fiber composition of the human corpus callosum. Brain Res 598:143–153. https://doi.org/10.1016/0006-8993(92)90178-c

    Article  CAS  PubMed  Google Scholar 

  2. Guner YE, Comert A, Sayaci EY, Korkmaz AC, Gungor Y, Morali Guler T, Kahilogullari G, Savas A (2023) Microsurgical anatomy of the anterior cerebral artery and the arterial supply of the cingulate gyrus. Surg Radiol Anat 45:351–358. https://doi.org/10.1007/s00276-023-03083-1

    Article  PubMed  Google Scholar 

  3. Gupta T, Singh B, Kapoor K, Gupta M, Kochar S (2008) Corpus callosum morphometry: comparison of fresh brain, preserved brain and magnetic resonance imaging values. Anat Sci Int 83:162–168. https://doi.org/10.1111/j.1447-073X.2008.00227.x

    Article  PubMed  Google Scholar 

  4. Hasan KM, Kamali A, Kramer LA, Papnicolaou AC, Fletcher JM, Ewing-Cobbs L (2008) Diffusion tensor quantification of the human midsagittal corpus callosum subdivisions across the lifespan. Brain Res 1227:52–67. https://doi.org/10.1016/j.brainres.2008.06.030

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Johnson SC, Farnworth T, Pinkston JB, Bigler ED, Blatter DD (1994) Corpus callosum surface area across the human adult life span: effect of age and gender. Brain Res Bull 35:373–377. https://doi.org/10.1016/0361-9230(94)90116-3

    Article  CAS  PubMed  Google Scholar 

  6. Laitinen LV (1972) Stereotactic lesions in the knee of the corpus callosum in the treatment of emotional disorders. Lancet 299:472–475. https://doi.org/10.1016/S0140-6736(72)90124-9

    Article  Google Scholar 

  7. Lee BY, Sohn JH, Choi MH, Lee SJ, Kim HS, Yang JW, Choi JS, Kim HS, Yi JH, Tack GR, Chung SC (2009) A volumetric study of the corpus callosum in 20s and 40s Korean people. Brain Struct Funct 213:463–467. https://doi.org/10.1007/s00429-009-0209-5

    Article  PubMed  Google Scholar 

  8. Neumaier F, Paterno M, Alpdogan S, Tevoufouet EE, Schneider T, Hescheler J, Albanna W (2017) Surgical approaches in psychiatry: a survey of the world literature on psychosurgery. World Neurosurg 97:603–634. https://doi.org/10.1016/j.wneu.2016.10.008

    Article  PubMed  Google Scholar 

  9. Nowinski WL (2008) Towards construction of an ideal stereotactic brain atlas. Acta Neurochir (Wien) 150:1–14. https://doi.org/10.1007/s00701-007-1270-6

    Article  PubMed  Google Scholar 

  10. Okanishi T, Fujimoto A (2021) Corpus callosotomy for controlling epileptic spasms: a proposal for surgical selection. Brain Sci 11:1601. https://doi.org/10.3390/brainsci11121601

    Article  PubMed  PubMed Central  Google Scholar 

  11. Ozdemir ST, Ercan I, Sevinc O, Guney I, Ocakoglu G, Aslan E, Barut C (2007) Statistical shape analysis of differences in the shape of the corpus callosum between genders. Anat Rec (Hoboken) 290:825–830. https://doi.org/10.1002/ar.20558

    Article  PubMed  Google Scholar 

  12. Park HJ, Kim JJ, Lee SK, Seok JH, Chun J, Kim DI, Lee JD (2008) Corpus callosal connection mapping using cortical gray matter parcellation and DT-MRI. Hum Brain Mapp 29:503–516. https://doi.org/10.1002/hbm.20314

    Article  PubMed  Google Scholar 

  13. Patra A, Singla RK, Chaudhary P, Malhotra V (2020) Morphometric analysis of the corpus callosum using cadaveric brain: an anatomical study. Asian J Neurosurg 15:322–327. https://doi.org/10.4103/ajns.AJNS_328_19

    Article  PubMed  PubMed Central  Google Scholar 

  14. Puthanveetil A, Balan R (2017) Morphometric analysis of corpus callosum—a study in cadaver and MRI. J Evid Based Med Healthc 4:3219–3222. https://doi.org/10.18410/jebmh/2017/639

    Article  Google Scholar 

  15. Shah A, Jhawar S, Goel A, Goel A (2021) Corpus callosum and its connections: a fiber dissection study. World Neurosurg 151:e1024–e1035. https://doi.org/10.1016/j.wneu.2021.05.047

    Article  PubMed  Google Scholar 

  16. Taghipour M, Ghaffarpasand F (2018) Corpus callosotomy for drug-resistant schizophrenia; novel treatment based on pathophysiology. World Neurosurg 116:483–484. https://doi.org/10.1016/j.wneu.2018.04.113

    Article  PubMed  Google Scholar 

  17. Talairach J, Rayport M, Tournoux P (1988) Co-planar stereotaxic atlas of the human brain: 3-dimensional proportional system: an approach to cerebral imaging. Thieme, Stuttgart

    Google Scholar 

  18. Uda T, Kunihiro N, Umaba R, Koh S, Kawashima T, Ikeda S, Ishimoto K, Goto T (2021) Surgical aspects of corpus callosotomy. Brain Sci 11:1608. https://doi.org/10.3390/brainsci11121608

    Article  PubMed  PubMed Central  Google Scholar 

  19. Vaddiparti A, Huang R, Blihar D, Du Plessis M, Montalbano MJ, Tubbs RS, Loukas M (2021) The evolution of corpus callosotomy for epilepsy management. World Neurosurg 145:455–461. https://doi.org/10.1016/j.wneu.2020.08.178

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

The authors sincerely thank those who donated their bodies to science so that anatomical research could be performed. Results from such research can potentially increase mankind's overall knowledge that can then improve patient care. Therefore, these donors and their families deserve our highest gratitude. The authors wish to thank the senior draftsmen Caner Ruhi CAVLAZ and Burhan AVCI for the elaborate analyses of morphometric data. The authors also wish to thank Enago for English editing and manuscript proofreading services.

Funding

No funding was received for conducting this study.

Author information

Authors and Affiliations

  1. Department of Neurosurgery, School of Medicine, Yuksek Ihtisas University, Ankara, Turkey

    Yahya Efe Guner

  2. Department of Anatomy, School of Medicine, Ankara University, Ankara, Turkey

    Ayhan Comert & Yigit Gungor

  3. Department of Radiology, School of Medicine, Yuksek Ihtisas University, Ankara, Turkey

    Aydın Aslan

Authors
  1. Yahya Efe Guner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ayhan Comert
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Aydın Aslan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yigit Gungor
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by YEG, YG, and AC. The first draft of the manuscript was written by YEG, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Ayhan Comert.

Ethics declarations

Conflict of interest

All authors certify no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or nonfinancial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript. The authors declare that they have no conflicts of interest.

Ethical approval

This is a cadaveric and radiological study, and all cadavers were supplied from a donated institution with subjects giving written informed consent for the use of samples in scientific studies. All the performed procedures in this study that involve cadavers followed the ethical standards of the Institutional Review Board and the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Radiological data were collected after approval from the Liv Hospital ethics committee (Approval Number: 2022/004).

Consent to publication

The authors affirm that human research participants provided informed consent for publication of the images as figures.

Informed consent

Informed consent was obtained from all subjects included in the study.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Guner, Y.E., Comert, A., Aslan, A. et al. Corpus callosum area and sectioning: a radioanatomical study correlated with MRI and cadaver morphometry. Surg Radiol Anat 45, 1427–1433 (2023). https://doi.org/10.1007/s00276-023-03206-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00276-023-03206-8

Keywords

Search

Navigation