Abstract
Purpose: To evaluate different vein grafts for luminal coating of endovascular stents in normal canine arteries.
Methods: Twenty-four tantalum Strecker stents were coated with either autologous (n= 10), denatured heterologous (n= 11), or denatured homologous vein grafts (n= 3). The carotid artery (n= 11) and the iliac artery (n= 13) were stented using a transfemoral approach. Angiograms were performed at days 0, 7, and 21, and months 3, 6, and 9. All grafts underwent histological examination.
Results: Eight of 10 autologous vein grafts showed patency during the whole observation period of 9 months, without histological signs of inflammation. Denatured heterologous vein grafts revealed acute (n= 3), subacute (n= 5), or delayed (n= 3) vessel occlusion. Hyaloid transformation of the vein graft and lympho-plasmacellular formations were seen. Denatured homologous vein grafts showed acute vessel occlusion. Although significant inflammatory tissue response was seen, no host-versus-graft reaction was present.
Conclusion: Autologous vein graft-coated stents showed good biocompatibility in canine arteries. Preparation was cumbersome and required surgical venae-sectio. Denatured vein grafts, however, were limited by inflammatory reactions.
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Schellhammer, F., Haberstroh, J., Wakhloo, A. et al. Vein Graft-Coated Vascular Stents: A Feasibility Study in a Canine Model. Cardiovasc Intervent Radiol 21, 158–164 (1998). https://doi.org/10.1007/s002709900234
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DOI: https://doi.org/10.1007/s002709900234