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Intra-Arterial Injection of Temporary Embolic Material Through a Needle Inserted into the Radial or Ulnar Artery for Distal and Proximal Interphalangeal Joint Osteoarthritis: A Retrospective Study of 92 Patients

  • Clinical Investigation
  • Embolisation (arterial)
  • Published:
CardioVascular and Interventional Radiology Aims and scope Submit manuscript

Abstract

Purpose

To assess the efficacy and safety of intra-arterial injection of imipenem/cilastatin sodium (IPM/CS) via a needle placed into the radial artery or ulnar artery (RA/UA) for distal interphalangeal and proximal interphalangeal joint osteoarthritis (DIP/PIP-OA).

Materials and Methods

This is a retrospective single-arm cohort study. Ninety-two patients [92% women, mean (SD) age 55(8.3) years] with a primary DIP/PIP-OA meet the American College of Rheumatology criteria for hand osteoarthritis with pain ≥ 4 on the 0–10 numeric rating scale (NRS) were enrolled. All procedures were performed by injecting IPM/CS through a 24-gauge needle percutaneously inserted into the RA/UA. Two procedures were planned; the second procedure was scheduled 1–2 months after the first. NRS, Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH) score, Patient Global Impression of Change (PGIC) scale, and procedure-related adverse events were evaluated.

Results

Technical success, defined as injection of IPM/CS into the RA/UA, was achieved in all patients. Clinical success, defined as a reduction of 2 points or more in the NRS at 12 months, was 77% (95% confidence interval 68–85%). The NRS improved from the baseline to 3, 6, and 12 months (7.8 ± 1.6 vs. 3.8 ± 2.6, 3.9 ± 2.7, and 4.0 ± 2.8, respectively, all p < 0.001). The QuickDASH score improved from the baseline to 12 months (27 ± 15 vs. 19 ± 17, p < 0.001) respectively. No major adverse events were observed.

Conclusions

Intra-arterial injection of IPM/CS is a feasible treatment option for DIP/PIP-OA.

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Acknowledgements

Not applicable.

Funding

This study received no funding support.

Author information

Author notes

    Authors and Affiliations

    1. Department of Radiology, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

      Takatoshi Kubo

    2. Musculoskeletal Intervention Center, Okuno Clinic Tokyo, 4th Fl Ginrei Bldg., 7-8-4, Roppongi, Minato-ku, Tokyo, 106-0032, Japan

      Takatoshi Kubo, Eiji Sugihara, Masaya Nakata & Yuji Okuno

    3. Musculoskeletal Intervention Center, Okuno Clinic Osaka, 3rd Fl Shinsaibashi Front Bldg., 3-5-11, Minamifunaba, Chuo-ku, Osaka City, Osaka, 542-0081, Japan

      Koichi Miyazaki

    4. Musculoskeletal Intervention Center, Okuno Clinic Kobe, B1 Fl, 1-2-1, Sannomiyacho, Chuo-ku, Kobe City, Hyogo, 650-0021, Japan

      Masahiko Shibuya

    Author notes

    1. Takatoshi Kubo and Koichi Miyazaki contributed equally to the manuscript.

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      Correspondence to Yuji Okuno.

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      Yuji Okuno has received consulting fee from Asahi Intecc, lecture fee from Terumo, and Daiichi Sankyo outside the submitted work. The rest of the authors declare that they have no conflict of interest.

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      The Institutional Review Board of Okuno Clinic approved this study (Approval Number: OC IRB 2021-102).

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      Kubo, T., Miyazaki, K., Shibuya, M. et al. Intra-Arterial Injection of Temporary Embolic Material Through a Needle Inserted into the Radial or Ulnar Artery for Distal and Proximal Interphalangeal Joint Osteoarthritis: A Retrospective Study of 92 Patients. Cardiovasc Intervent Radiol 46, 1375–1382 (2023). https://doi.org/10.1007/s00270-023-03514-x

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      • DOI: https://doi.org/10.1007/s00270-023-03514-x

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