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Percutaneous Ablative Therapies for the Management of Osteoid Osteomas: A Systematic Review and Meta-Analysis

  • Clinical Investigation
  • Non-Vascular Interventions
  • Published:
CardioVascular and Interventional Radiology Aims and scope Submit manuscript

Abstract

Purpose

To evaluate safety and efficacy of percutaneous ablative therapy for the treatment for osteoid osteomas.

Materials and Methods

PubMed database, Web of Science, and SCOPUS were searched from their inception until November 2019 for articles describing osteoid osteoma. Demographic data, success rates, pre- and post-procedure VAS scores, and complications were recorded. A random-effects meta-analyses of the VAS pain score at various time points were calculated.

Results

For radiofrequency ablation, VAS scores for pain at pre-procedure, 24–48 h, and 3–6 months yielded cumulative pain scores of 7.64 +/− 0.175, 0.78 +/− 0.186, and 0.02 +/− 0.0196, respectively. For cryoablation, VAS scores at pre-procedure, 24–48 h, and 3–6 months yielded cumulative pain scores of 8.46 +/− 0.549, 0.975 +/− 0.66, and 0.112 +/− 0.08, respectively. For laser ablation, VAS scores at pre-procedure and 24–48 h yielded cumulative pain scores of 4.94 +/− 1.42, and 0.506 +/− 0.268, respectively. For microwave ablation, VAS scores at pre-procedure, 24–48 h, and 3–6 months yielded cumulative pain scores of 6.14 +/− 1.07, 1.636 +/− 1.215, and 0 +/− 0.0, respectively. All ablation methods resulted in significant immediate and lasting pain reduction (p < 0.001).

Technical and clinical success rates and major complications for RFA, microwave ablation, laser ablation, and cryoablation did not differ significantly. Overall recurrence of bone pain at the same site occurred in 4.06% of all patients an average of 11 months post-procedure.

Conclusion

Percutaneous ablative therapies are safe and result in significant and lasting pain reduction as demonstrated through visual analog scale pain scores.

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Authors and Affiliations

  1. Division of Vascular and Interventional Radiology, Department of Radiology, Rutgers New Jersey Medical School, 185 South Orange Ave. MSB F-560, Newark, NJ, 07103, USA

    Srinidhi Shanmugasundaram, Shree Nadkarni, Abhishek Kumar & Pratik A. Shukla

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  1. Srinidhi Shanmugasundaram
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  2. Shree Nadkarni
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  3. Abhishek Kumar
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  4. Pratik A. Shukla
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Correspondence to Pratik A. Shukla.

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The protocol for this study was reviewed by the Institutional Review Board at our institution.

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Shanmugasundaram, S., Nadkarni, S., Kumar, A. et al. Percutaneous Ablative Therapies for the Management of Osteoid Osteomas: A Systematic Review and Meta-Analysis. Cardiovasc Intervent Radiol 44, 739–749 (2021). https://doi.org/10.1007/s00270-021-02804-6

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  • DOI: https://doi.org/10.1007/s00270-021-02804-6

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