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Evaluation of Temperature Distribution Around the Probe in Cryoablation of Lipiodol-Mixed-Tissue Phantom

  • Laboratory Investigation
  • Non-Vascular Interventions
  • Published:
CardioVascular and Interventional Radiology Aims and scope Submit manuscript

Abstract

Purpose

To determine whether lipiodol, which has low thermal conductivity, influences ice ball formation during cryoablation of a lipiodol-mixed-tissue phantom.

Materials and Methods

Lipiodol-mixed-tissue phantoms were created by injecting lipiodol (4–6 ml) into the renal arteries of ex vivo porcine kidneys (lipiodol group). A cryoprobe (CryoHit™ Needle S) with a holder that was set with thermocouples at various positions around the cryoprobe was inserted. After freezing for 300 s, the followings were evaluated: ice ball size on CT, temperature distribution around the cryoprobe, and calculated distances at 0 °C and − 20 °C. Each variable was compared between lipiodol group (n = 6) those obtained in a control group without lipiodol injection (n = 6).

Results

Mean ice ball diameter (width/length) on CT was 22.1 ± 2.3/22.9 ± 2.3 mm in the lipiodol group and 21.6 ± 0.7/22.2 ± 1.3 mm in the control group. Mean cryoprobe temperature was − 118 ± 3.0 °C in the lipiodol group and − 117 ± 2.6 °C in the control group. In both groups, temperature at the 3 mm thermocouple reached approximately − 50 °C and was < 0 °C within ~ 10 mm of the cryoprobe. Temperature of 0/− 20 °C occurred at a mean distance from the cryoprobe of 11.1 ± 0.5/6.9 ± 0.4 mm in the lipiodol group and 11.0 ± 0.2/6.9 ± 0.2 mm in the control group. There was no significant difference in any variable between the groups.

Conclusion

The inclusion of lipiodol in a tissue phantom had no negative effects on ice ball formation that were related to thermal conductivity.

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Funding

This study was not supported by any funding.

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Authors and Affiliations

  1. Department of Radiology, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto, 602-8566, Japan

    Masanori Yamashita, Hiroshi Miura, Yu Ohara, Tatsuya Yoshikawa, Tatsuya Hirota & Kei Yamada

  2. Department of Mechanical Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan

    Takanobu Fukunaga & Hiroshi Takamatsu

  3. Department of Radiology, Kochi Medical School University, 185-1 Kohasu, Oko-cho, , Nankoku-shi, Kochi, 783-8505, Japan

    Takuji Yamagami

Authors
  1. Masanori Yamashita
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  2. Hiroshi Miura
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  3. Yu Ohara
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  4. Tatsuya Yoshikawa
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  5. Tatsuya Hirota
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  6. Takanobu Fukunaga
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  8. Takuji Yamagami
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  9. Kei Yamada
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Correspondence to Masanori Yamashita.

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Yamashita, M., Miura, H., Ohara, Y. et al. Evaluation of Temperature Distribution Around the Probe in Cryoablation of Lipiodol-Mixed-Tissue Phantom. Cardiovasc Intervent Radiol 44, 489–495 (2021). https://doi.org/10.1007/s00270-020-02710-3

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  • DOI: https://doi.org/10.1007/s00270-020-02710-3

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