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Lessons from EVA-3S and SPACE

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Abstract

Carotid endarterectomy (CEA) was established as the gold standard for treatment of carotid occlusive disease by several landmark papers published in the 1990s. With the continued trend toward less invasive therapies, carotid artery stenting (CAS) has challenged CEA for treatment of significant carotid artery disease. Several trials have now compared CEA and CAS and a subsequent Cochrane review indicated that the 30-day complication rates were equivalent. Unfortunately, comparative long-term data are still lacking. Two new trials comparing CAS with CAE in patients with symptomatic internal carotid artery disease have recently been published, but to what extent have they usefully added to the available data?

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References

  1. Mas JL, Chantellier G, Beyssen B, et al. (2006) Endarterectomy versus stenting in patients with symptomatic severe carotid stenosis. N Engl J Med 355(16):1660–1671

    Article  PubMed  CAS  Google Scholar 

  2. The SPACE Collaborative Group (2006) Thirty-day results from the SPACE trial of stent-protected angioplasty versus carotid endarterectomy in symptomatic patients: a randomised non-inferiority trial. Lancet 368(9543):1239–1247

    Article  Google Scholar 

  3. Beinart SC, Kolm P, Veledar E, et al. (2005) Long-term cost effectiveness of early and sustained dual oral antiplatelet therapy with clopidogrel given for up to one year after percutaneous coronary intervention results: from the Clopidogrel for the Reduction of Events During Observation (CREDO) trial. J Am Coll Cardiol 46(5):761–769

    Article  PubMed  CAS  Google Scholar 

  4. McKevitt FM, Randall MS, Cleveland TJ, Gaines PA, Tan KT, Venables GS (2005) The benefits of combined anti-platelet treatment in carotid artery stenting. Eur J Vasc Endovasc Surg 29(5):522–527

    Article  PubMed  CAS  Google Scholar 

  5. Hauthe EAM, Drescher R, Jansen C, Gissler M, Schwartz M, Forsting M, Jaeger HJ, Mathias KD (2006) Complications and follow-up after unprotected carotid artery stenting. CardioVasc Interv Radiol 29(4):511–518

    Article  Google Scholar 

  6. Verzini F, Cao P, De Rango P, et al. (2006) Appropriateness of learning curve for carotid artery stenting: an analysis of periprocedural complications. J Vasc Surg 44(6):1205–1211, discussion 1211–1212 (Epub 20 October 2006)

    Article  PubMed  Google Scholar 

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Correspondence to Peter A. Gaines.

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Beckett, D., Gaines, P.A. Lessons from EVA-3S and SPACE. Cardiovasc Intervent Radiol 31, 5–7 (2008). https://doi.org/10.1007/s00270-007-9196-1

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  • DOI: https://doi.org/10.1007/s00270-007-9196-1

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