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GP IIb/IIIa Blockade During Peripheral Artery Interventions

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Abstract

The activation of the platelet GP IIb/IIIa receptor is the final and common pathway in platelet aggregation. By blocking this receptor, platelet aggregation can be inhibited independently of the stimulus prompted the targeting of this receptor. Several years ago, three drugs have been approved for coronary artery indications. Since that time, there is increasing evidence that GP IIb/IIIa receptor blockade might have also an important role in peripheral arterial intervention. This article summarizes the action and differences of GP Ilb/IIIa receptor inhibitors and its possible indication in peripheral arteries.

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References

  1. Ouriel K, Castaneda F, McNamara T, et al. (2004) Reteplase monotherapy and reteplase/abciximab combination therapy in peripheral arterial occlusive disease: Results from the RELAX trial. J Vase Intervent Radiol 15(3):229–238

    Google Scholar 

  2. Yoon HC, Miller FJ (2002) Using a peptide inhibitor of the glycoprotein IIb/IIIa platelet receptor: Initial experience in patients with acute peripheral arterial occlusions. Am J Roentgentl 178(3):617–622

    Google Scholar 

  3. Drescher P, McGuckin J, Rilling WS, et al. (2003) Catheter-directed thrombolytic therapy in peripheral artery occlusions: Combining reteplase and abciximab. Am J Roentgenol 180(5):1385–1391

    Google Scholar 

  4. Tepe G, Hahn U, Pusich B, et al. (2001) New strategies in platelet inhibition in noncoronary interventions. Semin Vasc Surg 14(2):143–149

    Article  PubMed  CAS  Google Scholar 

  5. Ouriel K (2002) Current status of thrombolysis for peripheral arterial occlusive disease. Ann Vasc Surg 16(6):797–804

    Article  PubMed  Google Scholar 

  6. Cho L, Topol EJ, Balog C, et al. (2000) Clinical benefit of glycoprotein IIb/IIIa blockade with abciximab is independent of gender: Pooled analysis from EPIC, EPILOG and EPISTENT trials. Evaluation of 7E3 for the Prevention of Ischemic Complications. Evaluation in Percutaneous Transluminal Coronary Angioplasty to Improve Long-Term Outcome with Abciximab GP IIb/IIIa blockade. Evaluation of Platelet IIb/IIIa Inhibitor for Stent. J Am Coll Cardiol 36(2):381–386

    Article  PubMed  CAS  Google Scholar 

  7. Lincoff AM, Tcheng JE, Califf RM, et al. (1999) Sustained suppression of ischemic complications of coronary intervention by platelet GP IIb/IIIa blockade with abciximab: One-year outcome in the EPILOG trial. Evaluation in PTCA to Improve Long-term Outcome with abciximab GP IIb/IIIa blockade. Circulation 99(15):1951–1958

    PubMed  CAS  Google Scholar 

  8. Moliterno DJ, Topol EJ (1997) Conjunctive use of platelet glycoprotein IIb/IIIa antagonists and thrombolytic therapy for acute myocardial infarction. Thromb Haemost 78(1):214–219

    PubMed  CAS  Google Scholar 

  9. Connors JJ (2004) Phaniiacologic agents in stroke prevention, acute stroke therapy, and interventional procedures. J Vase Intervent Radiol 15:87–101

    Google Scholar 

  10. Herrmann HC, Moliterno DJ, Ohman EM, et al. (2000) Facilitation of early percutaneous coronary intervention after reteplase with or without abciximab in acute myocardial infarction: Results from the SPEED (GUSTO-4 Pilot) Trial. J Am Coll Cardiol 36(5):1489–1496

    Article  PubMed  CAS  Google Scholar 

  11. Ouriel K, Kandarpa K, Schuerr DM, et al. (1999) Prourokinase versus urokinase for recanalization of peripheral occlusions, safety and efficacy: The PURPOSE trial. J Vase Intervent Radiol 10(8):1083–1091

    Article  CAS  Google Scholar 

  12. Valji K (2000) Evolving strategies for thrombolytic therapy of peripheral vascular occlusion. J Vase Intervent Radiol 11(4):411–420

    Article  CAS  Google Scholar 

  13. de Lemos JA, Gibson CM, Antman EM, et al. (2001) Abciximab and early adjunctive percutaneous coronary intervention are associated with improved ST-segment resolution after thrombolysis: Observations from the TIMI 14 Trial. Am Heart 141(4):592–598

    Article  Google Scholar 

  14. Swischuk JL, Fox PF, Young K, et al. (2001) Transcatheter intraarterial infusion of rt-PA for acute lower limb ischemia: Results and complications. J Vasc Intervent Radiol 12(4):423–430

    Article  CAS  Google Scholar 

  15. Lincoff AM (2000) Potent complementary clinical benefit of abciximab and stenting during percutaneous coronary revascularization in patients with diabetes mellitus: Results of the EPISTENT trial. Am Heart J 139(2 Pt 2):S46–S52

    Article  PubMed  CAS  Google Scholar 

  16. ERASER Study Group (1999) Acute platelet inhibition with abciximab does not reduce in-stent restenosis (ERASER study). The ERASER Investigators. Circulation 100(8):799–806

    Google Scholar 

  17. Sacks D, Rundback JH, Martin LG (2000) Renal angioplasty/stent placement and hypertension in the year 2000. J Vasc Intervent Radiol 11(8):949–953

    Article  CAS  Google Scholar 

  18. Marso SP, Lincoff AM, Ellis SG, et al. (1999) Optimizing the percutaneous interventional outcomes for patients with diabetes mellitus: Results of the EPISTENT (Evaluation of platelet IIb/IIIa inhibitor for stenting trial) diabetic substudy. Circulation 100(25):2477–2484

    PubMed  CAS  Google Scholar 

  19. Tepe G, Schott U, Erley CM, et al. (1999) Platelet glycoprotein IIb/IIIa receptor antagonist used in conjunction with thrombolysis for peripheral arterial thrombosis. Am J Roentgenol 172(5):1343–1346

    CAS  Google Scholar 

  20. Duda SH, Tepe G, Luz O, et al. (2001) Peripheral artery occlusion: Treatment with abciximab plus urokinase versus with urokinase alone—A randomized pilot trial (the PROMPT Study). Platelet Receptor Antibodies in Order to Manage Peripheral Artery Thrombosis. Radiology 221(3):689–696

    Article  PubMed  CAS  Google Scholar 

  21. Hull JE, Hull MK, Urso JA (2004) Reteplase with or without abcixiamb for peripheral arterial occulsions: Efficacy and adverse events. J Vasc Intervent Radiol 15(6):557–564

    Google Scholar 

  22. Ouriel K, Veith FJ, Sasahara AA (1998) A comparison of recombinant urokinase with vascular surgery as initial treatment for acute arterial occlusion of the legs. Thrombolysis or Peripheral Arterial Surgery (TOPAS) Investigators. N Engl J Med 338(16):1105–1111

    Article  PubMed  CAS  Google Scholar 

  23. Hall KV (1962) The great saphenous vein used in-situ as an arterial shunt after extirpation of vein valves. Surgery 51:492–499

    PubMed  CAS  Google Scholar 

  24. Rutherford JB (2000) Endovascular interventions in the management of chronic lower extremity ischemia. In: JB (ed.) Vascular Surgery 2000; 5th ed. WB Saunders, Philadelphia, pp. 1058–1059

  25. Feiring A, Wesolowski AA, Lade S (2004) Primary stent-supported angioplasty for treatment of below-knee critcal limb ischemia and severe claudication: early and one-year outcomes. J Am Coll Cardiol 44(12):2307–2314

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Diagnostic Radiology, University of Tübingen, 72076, Tübingen, Germany

    Gunnar Tepe, Jakub Wiskirchen, Philippe Pereira, Claus D. Claussen & Stephen Miller

  2. Center for Diagnostic Radiology & Minimally Invasive Therapy, The Jewish Hospital, Berlin, Germany

    Stephan H. Duda

Authors
  1. Gunnar Tepe
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  2. Jakub Wiskirchen
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  3. Philippe Pereira
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  4. Claus D. Claussen
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  5. Stephen Miller
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  6. Stephan H. Duda
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Correspondence to Gunnar Tepe.

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Tepe, G., Wiskirchen, J., Pereira, P. et al. GP IIb/IIIa Blockade During Peripheral Artery Interventions. Cardiovasc Intervent Radiol 31, 8–13 (2008). https://doi.org/10.1007/s00270-005-0266-y

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  • DOI: https://doi.org/10.1007/s00270-005-0266-y

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