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Angiotensinogen and Plasminogen Activator Inhibitor-1 Gene Polymorphism in Relation to Renovascular Disease

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Abstract

The present study was designed to evaluate angiotensinogen (AGT) M235T and plasminogen activator inhibitor-1 (PAI-1) (4G/5G) polymorphisims in relation to the occurrence of atherosclerotic renal artery stenosis (ARAS) and recurrent stenosis. In this study, 30 patients were enrolled after angiographic demonstration of ARAS; 100 healthy subjects for AGT polymorphism and 80 healthy subjects for PAI-1 polymorphism were considered the control group. The patients were followed for a mean 46.1 ± 9.2 months. The patients had significantly higher frequencies of the MT genotype and the T allele than control group (χ2 = 18.2, p < 0.001 and χ2 = 11.5 p < 0.001). There were no significant differences in the PAI-1 genotype and allele findings when the data for all patients were compared with that for the controls (χ2= 2.45, p = 0.29 and χ2 = 0.019, p = 0.89). There were no significant differences in the genotype and allele findings for the patients with and without restenosis (p > 0.05). The C-reactive protein (CRP) level was higher in the patients with restenosis than in the patients without restenosis (7.694 ± 0.39 mg/L and 1.56 ± 1.08 mg/L) (p = 0.001). Our results suggest that the M235T MT genotype and T allele might be associated with increased risk of atherosclerotic renal artery stenosis. The CRP level might be an independent predictor for recurrent stenosis.

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Acknowledgments

The authors thank Mrs. Yasemic Genc (PhD), Department of Biostatistics, Ankara University Faculty of Medicine, for her help with the statistical analysis.

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Authors and Affiliations

  1. Department of Nephrology, Gazi University Faculty of Medicine, Ankara, Turkey

    Kadriye Altok Reis, Turgay Arinsoy, Yasemin Erten, Ulver Derici, Galip Guz, Musa Bali & Sukru Sindel

  2. Department of Radiology, Gazi University Faculty of Medicine, Ankara, Turkey

    Baran Onal & Erhan Ilgit

  3. Department of Pediatric Nephrology, Gazi University Faculty of Medicine, Ankara, Turkey

    Sevim Gonen & Oguz Soylemezoglu

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  1. Kadriye Altok Reis
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  2. Baran Onal
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Correspondence to Kadriye Altok Reis.

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Reis, K.A., Onal, B., Gonen, S. et al. Angiotensinogen and Plasminogen Activator Inhibitor-1 Gene Polymorphism in Relation to Renovascular Disease. Cardiovasc Intervent Radiol 29, 59–63 (2006). https://doi.org/10.1007/s00270-005-0072-6

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