Skip to main content
SpringerLink
Log in

Comparison of Small Intestinal Submucosa-Covered and Noncovered Nitinol Stents with PTFE Endografts in Injured Ovine Femoral Arteries: A Pilot Study

  • Published:
CardioVascular and Interventional Radiology Aims and scope Submit manuscript

Abstract

The purpose of this study was to compare performance of small intestinal submucosa (SIS)-covered endografts (SCEs) to polytetra-fluoroethylene (PTFE)-covered endografts (PCEs) and to bare nitinol stents (BSs) in injured sheep femoral artery (FA). Bare Zilver 6 mm × 40 mm nitinol stents (n = 6), Zilver stents covered with SIS (n = 6), and Palmaz stents 6 mm × 37 mm covered with PTFE (n = 6) were implanted in the balloon-injured FAs of nine female sheep. Follow-up arteriograms were obtained before animal sacrifice at 1, 3 and 6 months, with three animals at each time point. The FAs with the implanted device were explanted for histologic studies and morphologic measurements. Stent implantation was technically successful in all sheep. All BS and SCEs were patent at each time point. Five BSs and five SCEs exhibited formation of progressive eccentric intimal hyperplasia (IH) that was more advanced in SCE at 6 months. Cross-sectional area narrowing averaged 60% for BSs and 67% for SCEs. One BS, one SCE and two patent PCEs exhibited mild-to-moderate formation of concentric IH. Four PCS occluded one at 1 month, two at 3 months and one at 6 months. Performance of the devices placed into sheep FAs depended on their relation to the curving peri-articular portion of the FA during extremity flexion. BSs and SCEs placed in this portion exhibited progressive growth of eccentric IH while PCEs placed in this portion occluded.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5

Similar content being viewed by others

References

  1. SF Badylak GC Lantz AC Coffey LA Geddes (1989) ArticleTitleSmall intestinal submucosa as a large diameter vascular graft in the dog J Surg Res 47 74–80 Occurrence Handle10.1016/0022-4804(89)90050-4 Occurrence Handle1:STN:280:BiaB1Mvlsl0%3D Occurrence Handle2739401

    Article  CAS  PubMed  Google Scholar 

  2. GC Lantz SF Badylak MC Hiles AC Coffey LA Geddes K Kokini GE Sandusky RJ Morff (1993) ArticleTitleSmall intestinal submucosa as a vascular graft: a review J Invest Surg 6 297–310 Occurrence Handle1:STN:280:ByuD3c7ot1M%3D Occurrence Handle8399001

    CAS  PubMed  Google Scholar 

  3. SF Badylak AC Coffey GC Lantz WA Tacker LA Geddes (1994) ArticleTitleComparison of the resistance to infection of intestinal submucosa arterial auto grafts versus polytetrafluoroethylene arterial prostheses in a dog model J Vasc Surg 19 465–472 Occurrence Handle1:STN:280:ByuC2s3nslc%3D Occurrence Handle8126859

    CAS  PubMed  Google Scholar 

  4. MC Hiles SF Badylak GC Lantz K Kokini LA Geddes RJ Morf (1995) ArticleTitleMechanical properties of xenogenic small-intestinal submucosa when used as an aortic graft in the dog J Biomed Mater Res 29 883–895 Occurrence Handle1:CAS:528:DyaK2MXms1WlsLY%3D Occurrence Handle7593028

    CAS  PubMed  Google Scholar 

  5. D Pavcnik B Uchida HA Timmermans C Corless FS Keller J Rösch (2000) ArticleTitleSquare stent-based large vessel occluder JVIR 11 1227–1234 Occurrence Handle1:STN:280:DC%2BD3cvptVaisw%3D%3D Occurrence Handle11041484

    CAS  PubMed  Google Scholar 

  6. D Pavcnik BT Uchida FS Keller C Corless J Rösch (2000) ArticleTitleAortic and venous valve for percutaneous placement Min Invas Ther Allied Technol 9(3/4) 287–292

    Google Scholar 

  7. K Yamada D Pavcnik BT Uchida HA Timmermans C Corless Q Yin K Yamakado JW Park FS Keller J Rösch M Sato R Yamada (2001) ArticleTitleEndoluminal treatment of ruptured abdominal aortic aneurysm with small intestinal submucosa sandwich endografts: a pilot study in sheep Cardiovasc Intervent Radiol 24 99–105 Occurrence Handle10.1007/s002700000400 Occurrence Handle1:STN:280:DC%2BD3MzoslemtQ%3D%3D Occurrence Handle11443394

    Article  CAS  PubMed  Google Scholar 

  8. D Pavcnik B Uchida HA Timmermans FS Keller J Rösch (2001) ArticleTitleSquare stent: a new self-expandable endoluminal device and its applications Cardiovasc Intervent Radiol 24 207–217 Occurrence Handle10.1007/s00270-001-0041-7 Occurrence Handle1:STN:280:DC%2BD38%2Flt1CgsA%3D%3D Occurrence Handle11779008

    Article  CAS  PubMed  Google Scholar 

  9. D Pavcnik BT Uchida HA Timmermans C Corless M O’Hara N Toyota GL Moneta FS Keller J Rösch (2002) ArticleTitlePercutaneous bioprosthetic venous valve: a long- term study in sheep J Vasc Surg 35 598–602 Occurrence Handle10.1067/mva.2002.118825 Occurrence Handle11877716

    Article  PubMed  Google Scholar 

  10. N Toyota D Pavcnik W VanAlstine BT Uchida HA Timmermans Q Yin JA Kaufman K Ito FS Keller J Rösch (2002) ArticleTitleComparison of small intestinal submucosa- covered and noncovered nitinol stents in the sheep iliac arteries: a pilot study J Vasc Interv Radiol 13 489–498 Occurrence Handle11997357

    PubMed  Google Scholar 

  11. Getty R. (1975) Sisson and Grossman’s The anatomy of the domestic animals. WB Saunders, pp 994–995

  12. J Marin F Veith J Cynamon RE Parsons RT Lyon WD Suggs CW Bakal S Waahl LA Sanchez JG Yuan T Ohki (1996) ArticleTitleEffect of polytetra-fluoroethylene covering of Palmaz stents on the development of intimal hyperplasia in human iliac arteries J Vasc Interv Radiol 7 651–656 Occurrence Handle1:STN:280:ByiD2M3mvFc%3D Occurrence Handle8897327

    CAS  PubMed  Google Scholar 

  13. PG Anderson (1992) ArticleTitleRestenosis: animal models and morphometric techniques in studies of the vascular response to injury Cardiovasc Pathol 1 263–278 Occurrence Handle10.1016/1054-8807(92)90037-O

    Article  Google Scholar 

  14. RS Schwartz KC Huber JG Murphy WD Edwards AR Camrud RE Vliestra DR Holmes (1992) ArticleTitleRestenosis and the proportional neointimal response to coronary artery injury: results in a porcine model J Am Coll Cardiol 19 267–274 Occurrence Handle1:STN:280:By2C387ls1A%3D Occurrence Handle1732351

    CAS  PubMed  Google Scholar 

  15. R Kornowski MK Hong FO Tio O Bramwell H Wu MB Leon (1998) ArticleTitleIn-stent restenosis: contributions of inflammatory responses and arterial injury to neointimal hyperplasia J Am Coll Cardiol 31 224–230 Occurrence Handle10.1016/S0735-1097(97)00450-6 Occurrence Handle1:STN:280:DyaK1c%2Fos1SisQ%3D%3D Occurrence Handle9426044

    Article  CAS  PubMed  Google Scholar 

  16. RT Andrews AC Venbrux CA Magee DA Bova (1999) ArticleTitlePlacement of a flexible endovascular stent across the femoral joint: an in vivo study in the swine model J Vasc Interv Radiol 10 1219–1228 Occurrence Handle1:STN:280:DyaK1MvlsVehsQ%3D%3D Occurrence Handle10527199

    CAS  PubMed  Google Scholar 

  17. KH Barth R Virmani J Froelich T Takeda SV Lossef J Newsome R Jones D Lindisch (1996) ArticleTitlePaired comparison of vascular wall reactions to Palmaz stents, Strecker tantalum stents, and Wallstents in canine iliac and femoral arteries Circulation 93 2161–2169 Occurrence Handle1:STN:280:BymB2M7ovFU%3D Occurrence Handle8925585

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. OHSU, Dotter Interventional Institute Research Laboratories, Portland, OR, USA

    Manabu Nakata, Dusan Pavcnik, Barry T. Uchida, Hans A. Timmermans, Naoyuki Toyota, Masaki Terada, Elias Brountzos, John A. Kaufman, Frederick S. Keller & Josef Rosch

  2. Department of Radiology, Osaka City University, Osaka, Japan

    Manabu Nakata

  3. Animal Disease Diagnostic Laboratory, Purdue University, West Laffayete, IN, USA

    William VanAlstine

Authors
  1. Manabu Nakata
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dusan Pavcnik
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Barry T. Uchida
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. William VanAlstine
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hans A. Timmermans
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Naoyuki Toyota
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Masaki Terada
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Elias Brountzos
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. John A. Kaufman
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Frederick S. Keller
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Josef Rosch
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Dusan Pavcnik.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nakata, M., Pavcnik, D., Uchida, B. et al. Comparison of Small Intestinal Submucosa-Covered and Noncovered Nitinol Stents with PTFE Endografts in Injured Ovine Femoral Arteries: A Pilot Study . CVIR 26, 459–467 (2003). https://doi.org/10.1007/s00270-003-3008-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00270-003-3008-z

Keywords

Search

Navigation