Skip to main content

Pulmonary Recruitment Maneuver Reduces Shoulder Pain and Nausea After Laparoscopic Cholecystectomy: A Randomized Controlled Trial

Abstract

Background

Pain and nausea are common after laparoscopic surgery. This prospective, randomized, controlled trial aimed to investigate postoperative pain and as a secondary endpoint nausea, when performing a ventilator-piloted Pulmonary Recruitment Maneuvre (PRM) at the end of laparoscopic cholecystectomy.

Method

Patients having elective laparoscopic cholecystectomy were randomized to either ordinary exsufflation or ventilator-piloted PRM, to evacuate intra-abdominal carbon dioxide (CO2) before abdominal closure. A questionnaire with numeric rating scales (NRS) was utilized to evaluate pain and nausea at five occasions during 48 h following surgery. Analgesic and antiemetic treatment was also analyzed.

Results

147 patients were analyzed, 76 receiving PRM and 71 controls. Overall pain was well controlled, with no significant difference between the groups regarding incidence (P=0.149) nor intensity (P=0.739). Incidence of shoulder pain was lower in the PRM group during the 48 postoperative hours, 44.7% versus 63.4% (P=0.023). The number needed to treat (NNT) to reduce shoulder pain was 6 (95% Confidence Interval, CI, 2.9–35.5) for the 48-h period. Incidence of nausea was lower in the PRM group during the 48-h period, 51.3% versus 70.4% (P=0.018). NNT was 6 (95% CI 2.9–27.4) for the 48-h period. Nausea intensity was lower in the PRM group during the 48 h (P=0.025). Fewer in the PRM population required antiemetics, 25.0% versus 42.3% (P=0.027).

Conclusion

A ventilator-piloted PRM at the end of laparoscopic cholecystectomy reduced incidence of shoulder pain, and incidence and intensity of nausea. Clinical trial registration www.clinicaltrials.gov. Identifier: NCT03026543.

Introduction

Cholelithiasis affects up to 20% of the population in developed countries. The surgical treatment of choice worldwide is laparoscopic cholecystectomy [1]. Pain and nausea following the procedure are important reasons for prolonged hospital stay and readmissions [2]. In a previous study, we found that a pulmonary recruitment maneuvre (PRM) reduced pain after bariatric surgery [3], consistent with results from other studies, mainly gynecological [4,5,6,7,8,9,10]. This trial aimed to investigate postoperative pain when performing a ventilator-piloted PRM at the end of laparoscopic cholecystectomy. Nausea was analyzed as a secondary endpoint.

The theory behind the benefit of PRM is that part of the post-laparoscopic pain is due to trapped intra-abdominal CO2 [11,12,13,14,15]. The entrapped gas may irritate or stretch the diaphragm, cause local acidosis and supposedly initiates referred shoulder pain via its effect on the phrenic nerve. [4, 16] PRM lowers the diaphragm, which in turn raises the intra-abdominal pressure, hence mechanically facilitates evacuation of CO2 [4,5,6].

Methods

This prospective, randomized, controlled trial was conducted in a secondary level hospital, engaging both experienced staff and staff under education, aspiring results of clinical significance. Participants, postoperative personnel and the investigator registering data were blinded to group affiliation. All study procedures were approved by the Regional Ethical Review Board in Linköping, Sweden (2014/120-31). The trial was registered at www.clinicaltrials.gov; registration number: NCT03026543.

Inclusion criteria: adults (>18 years); American Society of Anesthesiologists (ASA) physical status classification I-II (not including body mass index as a health variable); patients scheduled for elective laparoscopic cholecystectomy. Written consent was obtained. Exclusion criteria: acute cholecystitis, pancreatitis or cholangitis; conversion to open surgery; endoscopic retrograde cholangiopancreatography (ERCP) during or after surgery; extra surgical procedure; complications classified as Clavien-Dindo grade (CD)≥II [17].

Patients were consecutively enrolled and randomized to one of two equally sized groups; intervention with PRM or control. Block randomization was computer-generated by an independent statistician, and the allocation decision was placed in sealed, opaque, sequentially numbered envelopes. The envelope in turn followed the participant to theater, where it was opened by the anesthetic staff. Preoperatively, participants filled in a health declaration. Six weeks of non-smoking was a prerequisite for surgery.

Four-port laparoscopic cholecystectomy in anti-Trendelenburg position was performed. Gas pressure was maximum 12 mm Hg. General anesthesia was monitored by an anesthesiologist and nurse. Induction was achieved with either remifentanil and propofol or alfentanil and thiopental, the latter for patients with gastroesophageal reflux. Maintenance anesthesia was with remifentanil as analgesic, and propofol or sevoflurane in oxygen-enriched air as hypnotic. Pressure regulated volume control was standard ventilator mode. The surgeon was either an attending or a resident assisted by a senior colleague. Peroperative cholangiography was performed, according to Swedish routine. If a stone were obstructing the bile duct, an ERCP was performed during surgery or scheduled the following day, and the patient would then be excluded from the study.

In both groups, intra-abdominal CO2 was evacuated passively through the open sleeve valve of the epigastria port, while the surgeon applied gentle abdominal pressure. In the intervention group, a PRM was performed according to a specific protocol [3] before removal of the port, using the ventilator (GE Datex-Ohmeda Aisys, Madison, WI, United States). During one-minute of pressure-controlled ventilation, the patient received 6 breaths with a total pressure of 40 cm H2O. CO2 is heavier than air [18], wherefore PRM was performed with the patient in supine position to avoid retained CO2 in the abdominal cavity. After gas exsufflation, the subumbilical fascia was sutured. Incisions were sutured intracutaneously. Local anesthesia (20 ml bupivacaine hydrochloride 5 mg/ml with epinephrine 5 ug/ml) was infiltrated subcutaneously around trocar incisions.

Participants received oral paracetamol preoperatively. 30 mg ketorolac and/or morphine was administered intravenously (IV) near the end of surgery. The morphine dose was documented. Droperidol (0.5 mg IV) and betamethasone (4 mg IV) were given as antiemetic prophylaxis. Those with a history of postoperative nausea and vomiting (PONV) also received 4 mg ondansetron IV. The analgesic regimen postoperatively consisted of 1 g paracetamol four times daily. In the post-anesthesia care unit IV opioids were given as needed, while a 5 mg immediate-release oxycodone capsule was offered as rescue analgesia in the surgical ward. While hospitalized, patients experiencing nausea were treated with ondansetron IV. The doses administrated were recorded for follow-up.

Participants completed a 48-h postoperative questionnaire, with the same questions asked at five different occasions, and the replies given by ticking boxes. Intensity of pain and nausea, respectively, was evaluated with a numeric rating scale (NRS), ranging from 0 (no pain/nausea) to 10 (worst imaginable pain/nausea) [19].

Assuming a clinically relevant difference in mean pain intensity score of 2 points between intervention and control groups, with a standard deviation of 3.5 points (based on results from Tsai et al. [6, 7]), the sample size required for 90% power, and α 0.05 was 69 participants per group, using a two-tailed Wilcoxon-Mann–Whitney U test (90% power and α 0.05). Including 83 patients in each group allowed for 20% loss to follow-up.

For statistical analysis, χ2 test was used for comparison of binominal variables and Mann–Whitney U test for continuous variables. Evolution of NRS scores over time was compared using analysis of variance (ANOVA) for repeated measures. Univariate analysis of variance was used to control for possible confounding factors. Results are presented as median (inter quartile range) or numbers with percentages. A P value<0.050 was considered statistically significant. Statistical analyses were carried out with SPSS 26.0 (SPSS Inc., Chicago, IL), except Number Needed to Treat (NNT) which was calculated with QuickCalcs (GraphPad Software, San Diego, CA).

Results

Participants were recruited as of December 2014 until December 2018. Loss to follow-up, due to exclusion or missing questionnaires, was greater than expected. The Regional Ethical Review Board granted our request to randomize another 47 patients to each group (2018/2-32). Consequently, 260 participants were included and randomized, 130 to PRM and 130 to control (Fig. 1).

Fig. 1
figure 1

CONSORT flow chart

Of 39 excluded participants, 21 had an ERCP, 14 had an extra surgical intervention (5 closures of mesenteric defects after previous bariatric surgery, 2 umbilical hernia repairs, 3 had extra ports because of intra-abdominal adhesions obstructing the view, and 4 received tube drainage (3 because of subtotal cholecystectomy)). Two had a complication; both postoperative infections: one requiring IV antibiotics and percutaneous drainage (CD III), and one with concomitant pancreatitis (CD II). Two participants should not have been enrolled, due to acute cholecystitis and pancreatitis, respectively.

Finally, 147 questionnaires were available for analysis, 76 in the intervention group (64 completed, 12 partially completed), and 71 in the control group (63 completed, 8 partially completed). A non-response analysis was performed on all available data, see Appendix. Apart for a shorter duration of surgery in the “loss to follow-up” group (85.5 (69.0–109.3) minutes compared to 95.0 (81.0–114.0) minutes), the analysis did not show any significant differences between the “loss to follow-up” group and the group with questionnaires.

Baseline characteristics were similar between the groups (Table 1). Clinical data are presented in Table 2. The only parameter with a significant difference between the groups was a somewhat longer duration of surgery in the PRM group. No pulmonary complication was observed.

Table 1 Patient characteristics at baseline
Table 2 Surgical characteristics

Incidence of overall pain did not differ significantly between the groups on any occasion. For the postoperative 48-h period, the incidence of overall pain (NRS 1–10) was 98.7% in the PRM group and 94.4% in the control group (P=0.149). Overall pain intensity did not differ over time (P=0.739), nor at a certain hour (Fig. 2).

Fig. 2
figure 2

Overall pain intensity

There was a significant difference in shoulder pain incidence favorable for the PRM group. During the 48 h after surgery, 44.7% suffered from shoulder pain in the PRM group, versus 63.4% in the control group (P=0.023). The Number Needed to Treat, NNT, to benefit from PRM was 6 (95% Confidence Interval, CI, 2.9–35.5). The incidence in shoulder pain was specifically lower in the PRM group 12 and 36 h after surgery (PRM 27.0% vs. control 46.4% at 12 h [P=0.016] and PRM 21.1% vs. control 38.2% at 36 h [P=0.027]) (Fig. 3). NNT was 6 (95% CI 2.9–26.1) at 12 h and 6 (95% CI 3.1–46.4) at 36 h after surgery.

Fig. 3
figure 3

Shoulder pain incidence

Incidence of wound pain differed at 4 and 24 h postoperatively, in favor of the control group (25.7% vs. 41.3% [P=0.047] and 41.8% vs. 60.3% [P=0.029]). The difference was not significant when analyzing the occurrence of wound pain during the whole 48-h period after surgery; 67.1% experienced wound pain in the PRM group, versus 54.9% in the control group (P=0.130).

Incidence of nausea (NRS 1–10) during the 48-h period after surgery was 51.3% in the PRM group and 70.4% in the control group (P=0.018). The incidence of nausea was specifically lower in the PRM group 4 and 12 h after surgery (PRM 33.8% vs. control 55.7% at 4 h [P=0.011] and PRM 24.7% vs. control 43.5% at 12 h [P=0.018]). The NNT to benefit from reduced nausea incidence was 6 (95% CI 2.9–27.4) during the 48-h period, 5 (95% CI 2.6–16.5) 4 h after surgery, and 6 (95% CI 2.9–28.5) 12 h after surgery.

Nausea intensity was low in both groups, though differed significantly between them during the 48 postoperative hours (P=0.025) (Fig. 4). At 4 h, after surgery NRS values were 0 (0.0–2.0) in the PRM group and 1 (0.0–4.0) in the control group (P=0.006), and at 12 h, 0 (0.0–0.5) in the PRM group and 0 (0.0–2.5) in the control group (P=0.015).

Fig. 4
figure 4

Nausea intensity

No one in the PRM group had vomited 4 h after surgery, while 13.0% had vomited in the control group (P=0.001). At 12 h, 9.6% had vomited in the PRM group and 16.4% in the control group (P=0.228). Vomiting later was rare. At 4 h, after surgery 94.5% of the participants in the PRM group were up on their feet, while only 82.6% in the control group (P=0.025).

Opioid consumption during hospital stay postoperatively did not differ significantly (Table 3).

Table 3 Postoperative characteristics

The percentage of patients receiving IV opioids postoperatively was somewhat larger in the intervention group. Although not part of the study protocol, nonsteroidal anti-inflammatory drugs (NSAID) were sometimes administered. In the PRM group 1.3% of the participants received NSAID, versus 9.9% in the control group (P=0.023). After discharge from hospital, there was no difference in analgesic consumption between the groups.

Antiemetics were more frequently needed in the control group postoperatively (P=0.027). The dose required was also higher in the control group (P=0.015). When adjusted for ondansetron given preoperatively, the difference between the groups was reinforced (P=0.003).

Discussion

This trial is the first that evaluated the effect of PRM on postoperative pain solely in patients treated with laparoscopic cholecystectomy, and the second to use the ventilator to perform PRM [3]. We found that a PRM significantly reduced the incidence of postoperative shoulder pain during the postoperative 48-h period. This is consistent with previous studies [4,5,6,7, 9, 15]. The NNT, to benefit from reduced shoulder pain incidence was 6, similar to NNT reported by Tsai et al. [7].

In studies investigating shoulder pain after laparoscopic cholecystectomy, the prevalence has been 36–80% (control populations) [20,21,22,23,24]. In this study, 64.3% of the control population suffered from shoulder pain, 44.7% in the PRM group. There seems to be a positive correlation between volume of sub-diaphragmatic gas and intensity in shoulder pain [11,12,13,14,15, 25]. Recent studies found that PRM efficiently evacuate sub-diaphragmatic gas [13,14,15, 25].

Incidence of wound pain differed at two occasions, 4 and 24 h after surgery, in favor of the control group. Wound pain incidence did not differ between the groups when evaluating the entire 48-h postoperative period. Kiyak et al. found wound pain score being lower in the control group 6 h after surgery, and Davari-Tanha et al. reported lower incision site pain in the control group 24 h after surgery [25, 26]. Two studies by Tsai et al. and one study by Güngördük did not find any difference between groups regarding neither incidence nor intensity of wound pain [6, 7, 27]. The varying results, and lack of a connecting theory, leave us in doubt of a correlation. Ryu et al. evaluated the effect of PRM combined with saline instillation on postoperative pain in wounds and shoulders. Their results showed that the relative pain severity was differently perceived postoperatively. Wound pain was considered more intense than shoulder pain in the intervention group, while the control group perceived shoulder pain more intense than wound pain [14]. Possibly, not experiencing shoulder pain shifts the attention to other pain areas.

Postoperative pain was well controlled in both groups, the median NRS score being maximum 2 in the PRM group and 3 in the control group. No significant difference was found between the groups regarding intensity of overall pain, though there was a trend in favor of the PRM group. Two previous studies have analyzed overall pain, both reporting less pain in the PRM group [3, 8]. Our study design, with many members of the hospital staff involved, intending to detect differences of generalizable clinical relevance, means minor differences in the care might appear. Potentially, this could obscure the results and explain why no significant difference in overall pain was detected.

Incidence of PONV after laparoscopic cholecystectomy ranges from 53 to 72% [28]. Despite routine PONV prophylaxis, PONV was frequent, affecting 70.4% in the control group, compared to 51.3% in the PRM group. The reduction in the PRM group was significant, and the NNT to benefit from this reduction was 6 patients overall. The two previous studies analyzing PRM in patients undergoing laparoscopic cholecystectomy (among others) did not comment on postoperative nausea [8, 15]. Nausea intensity was generally low, though significantly lower in the PRM group. The PRM population was up on their feet earlier, and the requirement of antiemetics was lower, further supporting a lower intensity of nausea in this group.

Duration of surgery in the PRM group was a few minutes longer than in the control group. 10 of 11 prior studies indicate that PRM do not prolong surgery [3, 4, 6, 7, 9, 13, 14, 25,26,27]. A reason surgical duration was slightly longer in our PRM group could be that the operating team had varying experience of the maneuvre.

That participants were excluded after randomization, due to for example ERCPs, could have entailed imbalances in baseline characteristics. Though the participants appear similar, we do recognize this as a limitation in the study protocol.

The anesthetic management was not completely standardized. It did not differ significantly between the groups though. Induction analgesia was achieved using remifentanil or alfentanil, both having rapid onset of action and short terminal half-lives [29]. Alfentanils duration of activity is < 10–24 min after a single dose [29, 30]. Remifentanil, also used to maintain anesthesia, has a terminal elimination half-life of 6–12 min, independent of renal and hepatic function [29]. Nausea and vomiting are common adverse effects of the selected analgesic and hypnotic drugs. Minor differences in anesthetic treatment ought therefore not to have biased our results.

Conclusions

Our study indicates that a one-minute, ventilator-piloted PRM reduces incidence of shoulder pain after laparoscopic cholecystectomy. It further suggests that the PRM result in reduced incidence and intensity of postoperative nausea, and decreased need for antiemetics. The maneuvre is safe and uncomplicated to perform.

References

  1. European Association for the Study of the Liver (EASL) (2016) Clinical Practice Guidelines on the prevention, diagnosis and treatment of gallstones. J Hepatol 65(1): 146–181

  2. McIntyre C, Johnston A, Foley D et al (2020) Readmission to hospital following laparoscopic cholecystectomy: a meta-analysis. Anaesthesiol Intensive Ther 52(1):47–55

    Article  Google Scholar 

  3. Kihlstedt Pasquier E, Andersson E (2018) Pulmonary recruitment manoeuvre reduces pain after laparoscopic bariatric surgery: a randomized controlled clinical trial. Surg Obes Relat Dis 14(3):386–392

    Article  Google Scholar 

  4. Phelps P, Cakmakkaya OS, Apfel CC et al (2008) A simple clinical manoeuvre to reduce laparoscopy-induced shoulder pain: a randomized controlled trial. Obstet Gynecol 111:1155–1160

    Article  Google Scholar 

  5. Sharami SH, Sharami MB, Abdollahzadeh M et al (2010) Randomized clinical trial of the influence of pulmonary recruitment manoeuvre on reducing shoulder pain after laparoscopy. J Obstet Gynaecol 30:505–510

    CAS  Article  Google Scholar 

  6. Tsai HW, Chen YJ, Ho CM et al (2011) Manoeuvres to decrease laparoscopy-induced shoulder and upper abdominal pain: a randomized controlled study. Arch Surg 146:1360–1366

    Article  Google Scholar 

  7. Tsai HW, Wang PH, Yen MS et al (2013) Prevention of postlaparoscopic shoulder and upper abdominal pain: a randomized controlled trial. Obstet Gynecol 121:526–531

    Article  Google Scholar 

  8. Khanna A, Sezen E, Barlow H et al (2013) Randomized clinical trial of a simple pulmonary recruitment manoeuvre to reduce pain after laparoscopy. Br J Surg 100:1290–1294

    CAS  Article  Google Scholar 

  9. Huili L, Caihong M, Xiaoqing Z et al (2014) Combined incisional ropivacaine infiltration and pulmonary recruitment manoeuvre for postoperative pain relief after diagnostic hysteroscopy and laparoscopy. Chin Med J 127:825–829

    Google Scholar 

  10. Pergialotis V, Vlachos DE, Kontzoglou K et al (2015) Pulmonary recruitment manoeuvre to reduce pain after laparoscopy: a meta-analysis of randomized controlled trials. Surg Endosc 29:2101–2108

    Article  Google Scholar 

  11. Jackson SA, Laurence AS, Hill JC (1996) Does post-laparoscopy pain relate to residual carbon dioxide? Anaesthesia 51:485–487

    CAS  Article  Google Scholar 

  12. Sarvestani AS, Zamiri M (2014) Residual pneumoperitoneum volume and postlaparoscopic cholecystectomy pain. Anesth Pain Med 4(4): e17366

  13. Ryu K, Choi W, Shim J et al (2017) The impact of a pulmonary recruitment manoeuvre to reduce post-laparoscopic shoulder pain: a randomized controlled trial. Eur J Obstet Gynecol Reprod Biol 208:55–60

    Article  Google Scholar 

  14. Ryu KH, Lee SH, Cho EA et al (2019) Comparison of impacts of intraperitoneal saline instillation with and without pulmonary recruitment manoeuvre on post-laparoscopic shoulder pain prevention: a randomized controlled trial. Surg Endosc 33(3):870–878

    Article  Google Scholar 

  15. Garteiz-Martínez D, Rodríguez-Ayala E, Weber-Sánchez A et al (2020) Pulmonary recruitment can reduce residual pneumoperitoneum and shoulder pain in conventional laparoscopic procedures: results of a randomized controlled trial. Surg Endosc. PMID: 32804268

  16. Mouton W, Bessell J, Otten K et al (1999) Pain after laparoscopy. Surg Endosc 13:445–448

    CAS  Article  Google Scholar 

  17. Clavien PA, Barkun J, Oliveira ML et al (2009) The Clavien-Dindo classification of surgical complications: five-year experience. Ann Surg 250:187–196

    Article  Google Scholar 

  18. National Center for Biotechnology Information (2021) PubChem compound summary for CID 280, Carbon dioxide. Retrieved 22 Mar 2021 from https://pubchem.ncbi.nlm.nih.gov/compound/Carbon-dioxide

  19. Ferreira-Valente MA, Pais-Ribeiro JL, Jensen MP (2011) Validity of four pain intensity rating scales. Pain 152(10):2399–2404

    Article  Google Scholar 

  20. Madsen MR, Jensen KE (1992) Postoperative pain and nausea after laparoscopic cholecystectomy. Surg Laparosc Endosc 2:303–305

    CAS  PubMed  Google Scholar 

  21. Lee IO, Kim SH, Kong MH et al (2001) Pain after laparoscopic cholecystectomy: the effect and timing of incisional and intraperitoneal bupivacaine. Can J Anesth 48:545–550

    CAS  Article  Google Scholar 

  22. Chang SH, Lee HW, Kim HK et al (2009) An evaluation of perioperative pregabalin for prevention and attenuation of postoperative shoulder pain after laparoscopic cholecystectomy. Anesth Analg 109(4):1284–1286

    Article  Google Scholar 

  23. Kandil TS, Hefnawy EE (2010) Shoulder pain following laparoscopic cholecystectomy: factors affecting the incidence and severity. J Laparoendosc Adv Surg Tech 20(8):677–682

    Article  Google Scholar 

  24. Bhattacharjee HK, Jalaludeen A, Bansal V et al (2017) Impact of standard-pressure and low-pressure pneumoperitoneum on shoulder pain following laparoscopic cholecystectomy: a randomised controlled trial. Surg Endosc 31(3):1287–1295

    Article  Google Scholar 

  25. Kiyak H, Yilmaz G, Ay N (2019) Semi-Fowler positioning in addition to the pulmonary recruitment manoeuvre reduces shoulder pain following gynaecologic laparoscopic surgery. Videosurgery Miniinvasive Tech 14(4):567–574

    Article  Google Scholar 

  26. Davari-Tanha F, Samimi S, Khalaj Z et al (2019) Comparison of intraperitoneal normal saline infusion with pulmonary recruitment manoeuvre in reducing shoulder and upper abdomen pain following gynecologic laparoscopic procedures: a randomized, controlled, triple-blind trial. Anesth Pain Med 9(3): e92444

  27. Güngördük K, Aşıcıoğlu O, Özdemir İA (2018) Effect of the pulmonary recruitment manoeuvre on pain after laparoscopic gynecological oncologic surgery: a prospective randomized trial. J Gynecol Oncol. 29(6): e92

  28. Awad K, Ahmed H, Abushouk AI et al (2016) Dexamethasone combined with other antiemetics versus single antiemetics for prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy: an updated systematic review and meta-analysis. Int J Surg 36(A): 152–163

  29. Colvin LA, Analgesic drugs, (2013). In: Aitkenhead AR, Smith G (eds) Smith & Aitkenhead’s textbook of anaesthesia, 6th edn. Churchill Livingstone, Elsevier, London, pp 76–78

    Google Scholar 

  30. Nauta J, de Lange S, Koopman D et al (1982) Anesthetic induction with Alfentanil: a new short-acting narcotic analgesic. Anesth Analg 61(3):267–272

    CAS  Article  Google Scholar 

Download references

Acknowledgements

The authors express their gratitude to anesthesiologists L. Abildgaard and H. Krook for their support in designing a ventilator-piloted PRM protocol. We also extend our appreciation to statistician Mats Fredriksson for his assistance with randomization and statistical analysis.

Funding

The study was supported by grants from Region Östergötland; RALF and Hälsofonden.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to E. Kihlstedt Pasquier.

Ethics declarations

Conflict of interest

The authors have no potential conflict of interest to disclose.

Ethical approval

All study procedures were approved by the Regional Ethical Review Board in Linköping, Sweden (2014/120-31 and 2018/2-32).

Informed consent

Informed consent was obtained from all individual participants included in the study.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary file1 (DOCX 20 kb)

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Kihlstedt Pasquier, E., Andersson, E. Pulmonary Recruitment Maneuver Reduces Shoulder Pain and Nausea After Laparoscopic Cholecystectomy: A Randomized Controlled Trial. World J Surg 45, 3575–3583 (2021). https://doi.org/10.1007/s00268-021-06262-6

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00268-021-06262-6