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Outcomes of Tracheal Resections in Well-Differentiated Thyroid Cancer—A case series and meta-analysis

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Abstract

Background

Tracheal invasion in thyroid cancer is a well-known form of advanced disease. There is an ongoing controversy over outcomes of tracheal shaving in this situation. The aim of this study was to compare the results of tracheal shaving to radical resections in patients with low-volume tracheal involvement.

Methods

An institutional case series and a meta-analysis was conducted. All studies that included patients diagnosed with well-differentiated thyroid cancer (WDTC) and tracheal invasion were analyzed. Patients with low-volume tracheal invasion (according to the Shin classification) were extracted from the various studies and subsequently included in this study. The outcomes of tracheal shaving and radical resection were consolidated and compared. All recurrences and mortality over 10 years of follow-up were calculated using the Kaplan–Meier method.

Results

Institutional case series included 22 patients diagnosed with WDTC and tracheal invasion that underwent resection. There was one case of recurrence (4.5%) during the follow-up period and no mortality. The meta-analysis yielded a total of 284 patients from six studies who met the inclusion criteria. The 10-year overall survival was 82.4% for the shave group and 80.8% for the resection group. The combined Kaplan–Meier curves revealed no statistically significant difference between the two techniques (hazard ratio [HR] = 0.86, P = .768). The combined 10-year local control rate of the shave group was 90.2%.

Conclusions

The outcomes of tracheal shaving in low-volume invasion are similar to more aggressive forms of tracheal resections. Shave resection is oncologically safe in carefully selected WDTC patients demonstrating minimal tracheal invasion.

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Author notes

  1. Anton Warshavsky and Roni Rosen have contributed equally.

Authors and Affiliations

  1. The Department of Otolaryngology, Head & Neck Surgery and Maxillofacial Surgery, Tel-Aviv ‘Sourasky’ Medical Center, ‘Sackler’ School of Medicine, Tel-Aviv University, 6 Weizmann Street, 6423906, Tel-Aviv, Israel

    Anton Warshavsky, Roni Rosen, Narin Nard-Carmel, Nidal Muhanna, Omer Ungar, Avraham Abergel, Dan M. Fliss & Gilad Horowitz

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  1. Anton Warshavsky
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  2. Roni Rosen
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  3. Narin Nard-Carmel
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Correspondence to Gilad Horowitz.

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Warshavsky, A., Rosen, R., Nard-Carmel, N. et al. Outcomes of Tracheal Resections in Well-Differentiated Thyroid Cancer—A case series and meta-analysis. World J Surg 45, 2752–2758 (2021). https://doi.org/10.1007/s00268-021-06172-7

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  • DOI: https://doi.org/10.1007/s00268-021-06172-7

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