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Prevention of Intra-abdominal Adhesions by Electrical Stimulation

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A Correction to this article was published on 18 May 2020

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Abstract

The study investigated the ability of transdermal electric stimulation to prevent the formation of intra-abdominal adhesions in the combination with Seprafilm® (anti-adhesive agent). One hundred and twenty-eight (128) rabbits were subjected to a surgical procedure to simulate the adhesion processes. After the simulation, the animals were divided into 4 groups (32 animals each), depending on the application of the methods of prevention: (1) control group (no anti-adhesives or electro-stimulation) (CG); (2) comparison group (applications of Seprafilm®) (SF); (3) comparison group 2 (transdermal electric stimulation of the abdominal muscles) TES; (4) group (transdermal electric stimulation + Seprafilm®) (TES + SF). We observed that the application of the Seprafilm® alone led to a significant decrease in the adhesive process compared to the control group (CG) (p < 0.01). The adhesion process in the group underwent transdermal electrical stimulation (TES) was significantly lower compared to the Seprafilm® group (SF) (p ≤ 0.05). The results demonstrated a significant decrease in the adhesion processes in the SF + TES group on days 1, 3, 7 and 14 in comparison with the CG group (p = 0.001), SF group (p = 0.001) and TES group (p = 0.01) group of animals. This study showed the efficacy of transdermal electrical muscle stimulation for the prevention of intra-abdominal adhesions. Moreover, the combination of Seprafilm® anti-adhesion agent and electrical muscle stimulation resulted in the complete absence of adhesions. Our findings indicate the potential of such strategy for further clinical application.

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Change history

  • 18 May 2020

    In the original version of this article, Ydyrys Almabayev’s, Timur Saliev’s, Aygul Almabayeva’s, Baimakhan Tanabayev’s, Maral Yergazina’s, and Zhandos Serikpayev’s first and last names were transposed.

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Authors and Affiliations

  1. Laboratory of Experimental Medicine, S.D. Asfendiyarov Kazakh National Medical University, 94, Tole-bi Str., Almaty, 050000, Republic of Kazakhstan

    Ildar R. Fakhradiyev, Ydyrys Almabayev, Timur Saliev, Maral Yergazina & Zhandos Serikpayev

  2. Astana Medical University, 49a Beibitshilik St., Nur-Sultan, 010000, Republic of Kazakhstan

    Aygul Almabayeva

  3. South-Kazakhstan Medical Academy, 1/1 Al-Farabi Square, Shymkent, 160019, Republic of Kazakhstan

    Baimakhan Tanabayev

  4. Department of Anatomy, Fukuoka University School of Medicine, Nanakuma Jonan-ku, Fukuoka, Japan

    Loreto B. Feril Jr.

Authors
  1. Ildar R. Fakhradiyev
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  2. Ydyrys Almabayev
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  3. Timur Saliev
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  4. Aygul Almabayeva
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  5. Baimakhan Tanabayev
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  6. Maral Yergazina
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  7. Zhandos Serikpayev
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  8. Loreto B. Feril Jr.
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Correspondence to Ildar R. Fakhradiyev.

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The original version of this article was revised: In the original version of this article, Ydyrys Almabayev’s, Timur Saliev’s, Aygul Almabayeva’s, Baimakhan Tanabayev’s, Maral Yergazina’s, and Zhandos Serikpayev’s first and last names were transposed.

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Fakhradiyev, I.R., Almabayev, Y., Saliev, T. et al. Prevention of Intra-abdominal Adhesions by Electrical Stimulation. World J Surg 44, 3351–3361 (2020). https://doi.org/10.1007/s00268-020-05508-z

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