Abstract
Background
Early diagnosis of acute mesenteric ischemia (AMI) based on clinical judgment has been proved to be too difficult. Therefore, it is important for identifying clinical parameters that can differentiate AMI from other acute abdomen upon presentation.
Methods
We analyzed a database of 106 consecutive patients admitted to the emergency ward for suspected AMI in whom diagnosis of AMI was confirmed by laparotomy, CT angiography or mesenteric angiography. The patients’ demographics, previous history, clinical signs, results of laboratory investigations and ultrasonography were collected. Diagnostic cutoff value of quantitative indexes was derived from the receiver operating curve. Multivariate logistic regression was used to identify risk factors for AMI and formulated these risk factors into a scoring system.
Results
A total of 45 patients (42.5%) were confirmed to have AMI. Compared with other acute abdomen, AMI had significantly increased level of white blood cell (Odds ratio (OR) 16.11, 95% confidence interval (CI) 1.10–235.34), red cell distribution width (OR 27.65, 95% CI 1.53–501.02), mean platelet volume (OR 16.06, 95% CI 1.48–174.50) and D-dimer (OR 42.91, 95% CI 2.56–718.09). A diagnostic score was calculated by adding points assigned to the four parameters, and a cutoff score of four best identified patients with AMI, with sensitivity, specificity, positive and negative predictive values of 97.8, 91.8, 89.8 and 98.2%, respectively.
Conclusion
This scoring system based on easily available parameters could be used as a useful tool for differentiating AMI from other acute abdomen in the emergency ward. Prospective studies with large sample remain needed for validating the results.
Similar content being viewed by others
References
Acosta S (2010) Epidemiology of mesenteric vascular disease: clinical implications. Semin Vasc Surg 23(1):4–8
Menke J (2010) Diagnostic accuracy of multidetector CT in acute mesenteric ischemia: systematic review and meta-analysis. Radiology 256(1):93–101
Lock G (2001) Acute intestinal ischaemia. Best Pract Res Clin Gastroenterol 15(1):83–98
Demir IE, Ceyhan GO, Friess H (2012) Beyond lactate: is there a role for serum lactate measurement in diagnosing acute mesenteric ischemia? Dig Surg 29(3):226–235
Evennett NJ, Petrov MS, Mittal A, Windsor JA (2009) Systematic review and pooled estimates for the diagnostic accuracy of serological markers for intestinal ischemia. World J Surg 33(7):1374–1383. doi:10.1007/s00268-009-0074-7
Chong CF, Adi MI, Thien A, Suyoi A, Mackie AJ, Tin AS, Tripathi S, Jaman NH, Tan KK, Kok KY, Mathew VV, Paw O, Chua HB, Yapp SK (2010) Development of the RIPASA score: a new appendicitis scoring system for the diagnosis of acute appendicitis. Singap Med J 51(3):220–225
Wicki J, Perneger TV, Junod AF, Bounameaux H, Perrier A (2001) Assessing clinical probability of pulmonary embolism in the emergency ward: a simple score. Arch Intern Med 161(1):92–97
Henes FO, Pickhardt PJ, Herzyk A, Lee SJ, Motosugi U, Derlin T, Lubner MG, Adam G, Schön G, Bannas P (2016) CT angiography in the setting of suspected acute mesenteric ischemia: prevalence of ischemic and alternative diagnoses. Abdom Radiol [Epub ahead of print]
Angelelli G, Scardapane A, Memeo M, Stabile Ianora AA, Rotondo A (2004) Acute bowel ischaemia: CT findings. Eur J Radiol 50(1):37–47
Furukawa A, Kanasaki S, Kono N, Wakamiya M, Tanaka T, Takahashi M, Murata K (2009) CT diagnosis of acute mesenteric ischemia from various causes. AJR Am J Roentgenol 192(2):408–416
Zweig MH, Campbell G (1993) Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clin Chem 39(4):561–577
Sise MJ (2010) Mesenteric ischemia: the whole spectrum. Scand J Surg 99(2):106–110
Schoots IG, Levi MM, Reekers JA, Lameris JS, van Gulik TM (2005) Thrombolytic therapy for acute superior mesenteric artery occlusion. J Vasc Interv Radiol 16(3):317–329
Block T, Nilsson TK, Björck M, Acosta S (2008) Diagnostic accuracy of plasma biomarkers for intestinal ischaemia. Scand J Clin Lab Invest 68(3):242–248
Kim J, Kim YD, Song TJ, Park JH, Lee HS, Nam CM, Nam HS, Heo JH (2012) Red blood cell distribution width is associated with poor clinical outcome in acute cerebral infarction. Thromb Haemost 108(2):349–356
Karagöz E, Tanoglu A, Doğan M (2015) Mean platelet volume: an emerging prognostic factor of infective endocarditis? Platelets 26(4):370
Alhan E, Usta A, Çekiç A, Saglam K, Türkyılmaz S, Cinel A (2012) A study on 107 patients with acute mesenteric ischemia over 30 years. Int J Surg 10(9):510–513
Altintoprak F, Arslan Y, Yalkin O, Uzunoglu Y, Ozkan OV (2013) Mean platelet volume as a potential prognostic marker in patients with acute mesenteric ischemia-retrospective study. World J Emerg Surg 8(1):49. doi:10.1186/1749-7922-8-49
Kisaoglu A, Bayramoglu A, Ozogul B, Atac K, Emet M, Atamanalp SS (2014) Sensitivity and specificity of red cell distribution width in diagnosing acute mesenteric ischemia in patients with abdominal pain. World J Surg 38(11):2770–2776. doi:10.1007/s00268-014-2706-9
Ofer A, Abadi S, Nitecki S, Karram T, Kogan I, Leiderman M, Shmulevsky P, Israelit S, Engel A (2009) Multidetector CT angiography in the evaluation of acute mesenteric ischemia. Eur Radiol 19(1):24–30
Acosta S, Nilsson T (2012) Current status on plasma biomarkers for acute mesenteric ischemia. J Thromb Thrombolysis 33(4):355–361
Karabulut KU, Narci H, Gul M, Dundar ZD, Cander B, Girisgin AS, Erdem S (2013) Diamine oxidase in diagnosis of acute mesenteric ischemia. Am J Emerg Med 31(2):309–312
van den Heijkant TC, Aerts BA, Teijink JA, Buurman WA, Luyer MD (2013) Challenges in diagnosing mesenteric ischemia. World J Gastroenterol 19(9):1338–1341
Oldenburg WA, Lau LL, Rodenberg TJ, Edmonds HJ, Burger CD (2004) Acute mesenteric ischemia: a clinical review. Arch Intern Med 164(10):1054–1062
Acknowledgements
The study was supported by Youth Foundation of Guangxi Medical University (No. GXMUYSF201506 and GXMUYSF201502) and the National Natural Science Foundation of China (No. 81360370).
Author's contributions
ZW and JQC contributed equally to this article; ZW, JQC, JLL and LT designed this study; ZW and JLL collected the data; ZW and JQC analyzed the data; JQC and LT interpreted the results; ZW drafted the article; JQC and LT revised the paper.
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Wang, Z., Chen, JQ., Liu, Jl. et al. A Novel Scoring System for Diagnosing Acute Mesenteric Ischemia in the Emergency Ward. World J Surg 41, 1966–1974 (2017). https://doi.org/10.1007/s00268-017-3984-9
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00268-017-3984-9