Skip to main content
Log in

Evaluation of Gastroesophageal Reflux Disease

  • Surgical Symposium Contribution
  • Published:
World Journal of Surgery Aims and scope Submit manuscript

Abstract

Introduction

Gastroesophageal reflux disease (GERD) may present with heartburn, regurgitation, dysphagia, chronic cough, laryngitis, or even asthma. The clinical presentation of GERD is therefore varied and poses certain challenges to the physician, especially given the limitations of the diagnostic testing.

Discussion

The evaluation of patients with suspected GERD might be challenging. It is based on the evaluation of clinical features, objective evidence of reflux on diagnostic testing, correlation of symptoms with episodes of reflux, evaluation of anatomical abnormalities, and excluding other causes that might account for the presence of the patient’s symptoms.

Conclusions

The diagnostic evaluation should include multiple tests, in addition to a thorough clinical examination.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Vakil N, van Zanten SV, Kahrilas P, Dent K, Jones R, Global Consensus Group (2006) The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol 101(8):1900–1920

    Article  PubMed  Google Scholar 

  2. Katz PO, Gerson LB, Vela MF (2013) Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol 108(3):308–328

    Article  PubMed  Google Scholar 

  3. Patti MG, Diener U, Tamburini A, Molena D, Way LW (2001) Role of esophageal function tests in the diagnosis of gastroesophageal reflux disease. Dig Dis Sci 46:597–602

    Article  CAS  PubMed  Google Scholar 

  4. Andolfi C, Bonavina L, Kavitt RT, Konda VJ, Asti E, Patti MG (2016) Importance of esophageal manometry and ph monitoring in the evaluation of patients with refractory gastroesophageal reflux disease: a multicenter study. J Laparoendosc Adv Surg Tech A 26(7):548–550

    Article  PubMed  Google Scholar 

  5. Patti MG, Fisichella PM, Perretta S (2001) Preoperative evaluation of patients with gastroesophageal reflux disease. J Laparoendosc Adv Surg Tech A 11(6):327–331

    Article  CAS  PubMed  Google Scholar 

  6. Jobe BA, Richter JE, Hoppo T et al (2013) Preoperative diagnostic work-up before antireflux surgery: an evidence and experience-based consensus of the esophageal diagnostic advisory panel. J Am Coll Surg 217(4):586–597

    Article  PubMed  Google Scholar 

  7. Shaw M, Dent J, Beebe T, Junghard O, Wiklund I, Lind T, Johnsson F (2008) The Reflux Disease Questionnaire: a measure for assessment of treatment response in clinical trials. Health Qual Life Outcomes 6:31

    Article  PubMed  PubMed Central  Google Scholar 

  8. Ducrotte P, Zerbib F (2007). ReQuest: a new questionnaire for the simultaneous evaluation of symptoms and well-being in patients with gastro-oesophageal reflux. Digestion, 75Suppl 1:79-86

  9. Campos GM, Peters JH, DeMeester TR, Oberg S, Crookes PF, Tan S, DeMeester SR, Hagen JA, Bremner CG (1999) Multivariate analysis of factors predicting outcome after laparoscopic Nissen fundoplication. J Gastrointest Surg 3:292–300

    Article  CAS  PubMed  Google Scholar 

  10. Weber C, Davis CS, Fisichella PM (2011) Current applications of evolving methodologies in gastroesophageal reflux disease testing. Dig Liver Dis 43(5):353–357

    Article  PubMed  Google Scholar 

  11. Bello B, Zoccali M, Gullo R et al (2013) Gastroesophageal reflux disease and antireflux surgery—What is the proper preoperative work-up? J Gastrointest Surg 17:14–20

    Article  PubMed  Google Scholar 

  12. Fisichella PM, Jalilvand A (2014) The role of impaired esophageal and gastric motility in end-stage lung diseases and after lung transplantation. J Surg Res 186(1):201–206

    Article  PubMed  Google Scholar 

  13. Andolfi C, Vigneswaran Y, Kavitt RT, Herbella FA, Patti MG (2017) Laparoscopic antireflux surgery: importance of patient’s selection and preoperative workup. J Laparoendosc Adv Surg Tech A 27(2):101–105. doi:10.1089/lap.2016.0322

    Article  PubMed  Google Scholar 

  14. Sidhwa F, Moore A, Alligood E, Fisichella PM. (2016) Diagnosis and treatment of the extraesophageal manifestations of gastroesophageal reflux disease. Ann Surg. Aug 5. PMID: 27455157

  15. Lord RV, Kaminski A, Oberg S et al (2002) Absence of gastroesophageal reflux disease in a majority of patients taking acid suppression medications after Nissen fundoplication. J Gastrointest Surg 6:3–9

    Article  PubMed  Google Scholar 

  16. Herbella FA, Andolfi C, Vigneswaran Y, Patti MG, Pinna BR (2016) Importance of esophageal manometry and pH monitoring for the evaluation of otorhinolaryngologic (ENT) manifestations of GERD. A multicenter study. J Gastrointest Surg 20(10):1673–1678

    Article  PubMed  Google Scholar 

  17. Lo KW, Mashimo H (2017) Establishing the diagnosis of GERD. In: Fisichella PM (ed) Failed antireflux therapy: analysis of causes and principles of treatment. Springer-Verlag, London (in press)

  18. Bredenoord AJ, Weustein BLAM, Smout AJPM (2005) Symptom association analysis in ambulatory gastro-oesophageal reflux monitoring. Gut 54(12):1810–1817

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Desjardin M, Luc G, Collet D, Zerbib F (2015) 24-hour pH-impedance monitoring on therapy to select patients with refractory reflux symptoms for antireflux surgery. A single center retrospective study. Neurogastroenterol Motil 28(1):146–152

    Article  PubMed  Google Scholar 

  20. Francis DO, Goutte M, Slaughter JC et al (2011) Traditional reflux parameters and not impedance monitoring predict outcome after fundoplication in extraesophageal reflux. Laryngoscope 121(9):1902–1909

    PubMed  Google Scholar 

  21. Lai Y-C, Wang P-C, Lin J-C (2008) Laryngopharyngeal reflux in patients with reflux esophagitis. World J Gastroenterol 14(28):4523–4528

    Article  PubMed  PubMed Central  Google Scholar 

  22. Fisichella PM, Reder NP, Gagermeier J, Kovacs EJ (2014) Usefulness of pH monitoring in predicting the survival status of patients with scleroderma awaiting lung transplantation. J Surg Res 189(2):232–237

    Article  PubMed  PubMed Central  Google Scholar 

  23. Fisichella PM, Patti MG (2009) Gastroesophageal reflux disease and morbid obesity: is there a relation? World J Surg 33(10):2034–2038. doi: 10.1007/s00268-009-0045-z

    Article  PubMed  Google Scholar 

  24. Allaix ME, Fisichella PM, Noth I, Herbella FA, Borraez Segura B, Patti MG (2014) Idiopathic pulmonary fibrosis and gastroesophageal reflux. Implications for treatment. J Gastrointest Surg 18(1):100–104

    Article  PubMed  Google Scholar 

  25. Galindo G, Vassalle J, Marcus SN, Triadafilopoulos G (2013) Multimodality evaluation of patients with gastroesophageal reflux disease symptoms who have failed empiric proton pump inhibitor therapy. Dis Esophagus 26(5):443–450

    Article  CAS  PubMed  Google Scholar 

  26. Bais JE, Samsom M, Boudesteijn EA, van Rijk PP, Akkermans LM, Gooszen HG (2001) Impact of delayed gastric emptying on the outcome of antireflux surgery. Ann Surg 234:139–146

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Weinstein DH, deRijke S, Chow CC, Foruraghi L, Zhao X, Wright EC, Whatley M, Maass-Moreno R, Chen CC, Wank SA (2013) A new method for determining gastric acid output using a wireless ph-sensing capsule. Aliment Pharmacol Ther 37(12):1198–1209

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Hayat JO, Yazaki E, Moore AT, Hicklin L, Dettmar P, Kang JY, Sifrim D (2014) Objective detection of esophago-pharyngeal reflux in patients with hoarseness and endoscopic signs of laryngeal inflammation. J Clin Gastroenterol 48(4):318–327

    Article  PubMed  Google Scholar 

  29. Fisichella PM, Davis CS, Lundberg PW, Lowery E, Burnham EL, Alex CG, Ramirez L, Pelletiere K, Love RB, Kuo PC, Kovacs EJ (2011) The protective role of laparoscopic antireflux surgery against aspiration of pepsin after lung transplantation. Surgery 150(4):598–606

    Article  PubMed  PubMed Central  Google Scholar 

  30. Fisichella PM, Davis CS, Gagermeier J, Dilling D, Alex CG, Dorfmeister JA, Kovacs EJ, Love RB, Gamelli RL (2011) Laparoscopic antireflux surgery for gastroesophageal reflux disease after lung transplantation. J Surg Res 170(2):e279–e286

    Article  PubMed  PubMed Central  Google Scholar 

  31. Rhagu G, Freudenberger TD, Yang S et al (2006) High prevalence of abnormal acid gastro-oesophageal reflux in idiopathic pulmonary fibrosis. EurRespir J 27:136

    Google Scholar 

  32. Mendez BM, Davis CS, Weber C, Joehl RJ, Fisichella PM (2012) Gastroesophageal reflux disease in lung transplant patients with cystic fibrosis. Am J Surg 204:21

    Article  Google Scholar 

  33. Patti MG, Gasper WJ, Fisichella PM, Nipomnick I, Palazzo F (2008) Gastroesophageal reflux disease and connective tissue disorders: pathophysiology and implications for treatment. J Gastrointest Surg 12:1900. doi:10.1007/s11605-008-0674-9 Epub 2008 Sep 3

    Article  PubMed  Google Scholar 

  34. Davis CS, Shankaran V, Kovacs EJ, et al. (2010) Gastroesophageal reflux disease after lung transplantation: pathophysiology and implications for treatment. Surgery, 148:737. Discussion 744e5

  35. Hartwig MG, Davis RD (2012) Gastroesophageal reflux disease induced aspiration injury following lung transplantation. Curr Opin Organ Transplant 17:474

    Article  PubMed  Google Scholar 

  36. Hoppo T, Jarido V, Pennathur A et al (2011) Antireflux surgery preserves lung function in patients with gastroesophageal reflux disease and end-stage lung disease before and after lung transplantation. Arch Surg 146:1041

    Article  PubMed  Google Scholar 

  37. Basseri B, Conklin JL, Pimentel M et al (2010) Esophageal motor dysfunction and gastroesophageal reflux are prevalent in lung transplant candidates. Ann Thorac Surg 90:1630

    Article  PubMed  Google Scholar 

  38. Allaix ME, Fisichella PM, Herbella FA, Patti MG (2014) Idiopathic pulmonary fibrosis and gastroesophageal reflux. Implications for treatment. J Gastrointest Surg Jan;18(1):100-4; discussion 104-5. doi: 10.1007/s11605-013-2333-z

  39. Davis CS, Mendez BD, Flint DV et al (2013) Pepsin concentrations are elevated in the bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis after lung transplantation. J Surg Res. doi:10.1016/j.jss.2013.06.011.:S0022-4804(13)00600-8

    PubMed Central  Google Scholar 

  40. Fisichella PM, Davis CS, Shankaran V et al (2012) The prevalence and extent of gastroesophageal reflux disease correlates to the type of lung transplantation. Surg Laparosc Endosc Percutaneous Tech 22:46

    Article  Google Scholar 

  41. Fisichella PM, Davis CS, Gagermeier J et al (2011) Laparoscopic antireflux surgery for gastroesophageal reflux disease after lung transplantation. J Surg Res 170:279

    Article  Google Scholar 

  42. Fisichella PM, Davis CS, Lowery E et al (2012) Pulmonary immune changes early after laparoscopic antireflux surgery in lung transplant patients with gastroesophageal reflux disease. J Surg Res 177:E65

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to P. Marco Fisichella.

Ethics declarations

Conflicts of interest

The authors have no conflicts of interest to declare

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Fisichella, P.M., Andolfi, C. & Orthopoulos, G. Evaluation of Gastroesophageal Reflux Disease. World J Surg 41, 1672–1677 (2017). https://doi.org/10.1007/s00268-017-3953-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00268-017-3953-3

Keywords

Navigation