Abstract
Gastroesophageal reflux disease (GERD) affects approximately 20% of the population in the United States, and its prevalence is increasing worldwide. Typical symptoms include heartburn, regurgitation, and dysphagia. However, patients often present with atypical symptoms such as chronic cough, laryngitis, or even asthma. Therefore, the evaluation of patients with suspected GERD should include not only a thorough clinical examination but also multiple diagnostic tests in order to detect anatomical abnormalities, obtain objective evidence of pathologic gastroesophageal reflux, and rule out other diseases that might account for the patients’ symptoms.
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References
El-Serag HN, Sweet S, Winchester CC, et al. Update on the epidemiology of gastro-esophageal reflux disease: a systematic review. Gut. 2014;63:871–80.
Sandler RS, Everhart JE, Donowitz M, et al. The burden of selected digestive diseases in the United States. Gastroenterology. 2002;122:1500–11.
Shaheen NJ, Hansen RA, Morgan DR, et al. The burden of gastrointestinal and liver diseases, 2006. Am J Gastroenterol. 2006;101(9):2128–38.
Vakil N, van Zanten SV, Kahrilas P, Dent K, Jones R, Global Consensus Group. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol. 2006;101(8):1900–20.
Jobe BA, Richter JE, Hoppo T, et al. Preoperative diagnostic workup before antireflux surgery: an evidence and experience-based consensus of the Esophageal Diagnostic Advisory Panel. J Am Coll Surg. 2013;217(4):586–97.
Campos GM, Peters JH, DeMeester TR, et al. Multivariate analysis of factors predicting outcome after laparoscopic Nissen fundoplication. J Gastrointest Surg. 1999;3(3):292–300.
Morgenthal CB, Lin E, Shane MD, et al. Who will fail laparoscopic Nissen fundoplication? Preoperative prediction of long-term outcomes. Surg Endosc. 2007;21:1978–84.
Schlottmann F, Herbella FA, Allaix ME, et al. Surgical treatment of gastroesophageal reflux disease. World J Surg. 2017;41(7):1685–90.
Gerson LB, Kahrilas PJ, Fass R. Insights into gastroesophageal reflux diseases-associated dyspeptic symptoms. Clin Gastroenterol Hepatol. 2011;9:824–33.
Patti MG, Diener U, Tamburini A, et al. Role of esophageal function tests in diagnosis of gastroesophageal reflux disease. Dig Dis Sci. 2001;46(3):597–602.
Sonnenberg A, Delcò F, El-Serag HB. Empirical therapy versus diagnostic tests in gastroesophageal reflux disease: a medical decision analysis. Dig Dis Sci. 1998;43(5):1001–8.
Ates F, Vaezi MF. New approaches to management of PPI-refractory gastroesophageal reflux disease. Curr Treat Options Gastroenterol. 2014;12(1):18–33.
Nasseri-Moghaddam S, Razjouyan H, Nouraei M, et al. Inter and intra-observer variability of the Los Angeles classification: a reassessment. Arch Iran Med. 2007;10:48–53.
Bello B, Zoccali M, Gullo R, et al. Gastroesophageal reflux disease and antireflux surgery-what is the proper preoperative work-up? J Gastrointest Surg. 2013;17(1):14–20.
Hirano I, Richter JE, Practice Parameters Committee of the American College of Gastroenterology. ACG practice guidelines: esophageal reflux testing. Am J Gastroenterol. 2007;102(3):668–85.
Neto RML, Herbella FAM, Schlottmann F, et al. Does DeMeester score still define GERD? Dis Esophagus. 2019;32(5):doy118.
Wiener GJ, Morgan TM, Cooper JB, et al. Ambulatory 24-hour esophageal ph monitoring. Reproducibility and variability of ph parameters. Dig Dis Sci. 1988;33:1127–33.
Weusten BL, Roelofs JM, Akkermans LM, et al. The symptom-association probability: an improved method for symptom analysis of 24-hour esophageal ph data. Gastroenterology. 1994;107:1741–5.
Schlottmann F, Andolfi C, Herbella FA, et al. GERD: presence and size of hiatal hernia influence clinical presentation, esophageal function, reflux profile, and degree of mucosal injury. Am Surg. 2018;84(6):978–82.
Agrawal A, Castell DO. Clinical importance of impedance measurements. J Clin Gastroenterol. 2008;42:579–83.
Vela MF. Non-acid reflux: detection by multichannel intraluminal impedance and ph, clinical significance and management. Am J Gastroenterol. 2009;104:277–80.
Francis DO, Goutte M, Slaughter JC, et al. Traditional reflux parameters and not impedance monitoring predict outcome after fundoplication in extraesophageal reflux. Laryngoscope. 2011;121:1902–9.
Allaix ME, Borraez BA, Patti MG. Gastroesophageal reflux disease: diagnostic evaluation. In: Fisichella PM, Allaix ME, Morino M, Patti MG, editors. Esophageal disease. New York: Springer Nature; 2014. p. 53–67.
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Schlottmann, F., Galvarini, M., Patti, M.G. (2020). Clinical and Diagnostic Evaluation of GERD. In: Patti, M., Di Corpo, M., Schlottmann, F. (eds) Foregut Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-27592-1_13
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DOI: https://doi.org/10.1007/978-3-030-27592-1_13
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