To the Editor
The findings by Cristobal et al. [1] help getting further insights into signaling pathways influencing Lcn-2 expression. The mechanism of Lcn-2 expression in cancerogenesis and metastasis is not well understood; however, activation of the phosphatidylinositol 3-kinase/Akt pathway as well as nuclear factor-κB activation to promote Lcn-2-dependent proliferation of tumor cells is still under debate. Lee et al. [2] showed a correlation between miR-138 and Lcn-2 in an in vitro model, although the paper lacks information on how miR-138 effects on the Lcn-2 gene itself or via other proteins. This is of importance as miR-138 is described to target various oncogenes like CCND1, p53, cyclins, MAP kinases, and others [3–5]. This might be an explanation for the interesting finding that miR-138 is downregulated in the metastatic tissue of liver but not lung metastases. To exclude bias due to small cohorts of patients (12 patients with liver metastasis, five patients with lung metastasis), confirmation of results in a larger patient series will be necessary, as stated by the authors in their conclusion. To summarize, miR-138 is identified as one target for the molecular regulatory mechanism of Lcn-2 that gives support to our descriptive data [6].
References
Cristóbal I, Torrejón B, González-Alonso P, Manso R, Rojo F, García-Foncillas J (2015) Downregulation of miR-138 as a contributing mechanism to Lcn-2 overexpression in colorectal cancer with liver metastasis. World J Surg. doi:10.1007/s00268-015-3241-z
Lee YC, Tzeng WF, Chiou TJ, Chu ST (2012) MicroRNA-138 suppresses neutrophil gelatinase-associated lipocalin expression and inhibits tumorigenicity. PLoS ONE 7(12):e52979. doi:10.1371/journal.pone.0052979
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Liu X, Lv XB, Wang XP, Sang Y, Xu S, Hu K et al (2012) MiR-138 suppressed nasopharyngeal carcinoma growth and tumorigenesis by targeting the CCND1 oncogene. Cell Cycle 11(13):2495–2506. doi:10.4161/cc.20898
Ye D, Wang G, Liu Y, Huang W, Wu M, Zhu S et al (2012) MiR-138 promotes induced pluripotent stem cell generation through the regulation of the p53 signaling. Stem Cells 30(8):1645–1654. doi:10.1002/stem.1149
Maier HT, Aigner F, Trenkwalder B, Zitt M, Vallant N, Perathoner A et al (2014) Up-regulation of neutrophil gelatinase-associated lipocalin in colorectal cancer predicts poor patient survival. World J Surg 38(8):2160–2167. doi:10.1007/s00268-014-2499-x
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Maier, H., Aigner, F. Upregulation of Neutrophil Gelatinase-Associated Lipocalin in Colorectal Cancer Predicts Poor Patient Survival: Reply. World J Surg 40, 1023 (2016). https://doi.org/10.1007/s00268-015-3309-9
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DOI: https://doi.org/10.1007/s00268-015-3309-9