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Vitamin E Deficiency Begins within 6 Months after Gastrectomy for Gastric Cancer

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Abstract

Background

To clarify factors related to vitamin E malabsorption after gastric surgery, we evaluated serum vitamin E levels in patients who had undergone gastrectomy for gastric cancer.

Methods

We studied 39 patients (26 men, 13 women; mean age, 61.7 years) who underwent gastrectomy for early gastric cancer. Surgical procedures included 24 subtotal gastrectomies and 15 total gastrectomies. We measured serum levels of vitamin E before and 3, 6, 9, and 12 months after gastrectomy. A level of less than 0.75 mg/dl was defined as a low vitamin E level.

Results

Serum vitamin E levels decreased to less than 0.75 mg/dl in 6 (15.4 %) of the 39 patients within 6 months after gastrectomy and in 7 (17.9 %) of the 39 patients within 1 year after gastrectomy. The proportion of patients with a low serum vitamin E level was significantly higher in the total gastrectomy group (p = 0.002). A low vitamin E level was significantly associated with a low total cholesterol level. Total cholesterol levels in low vitamin E levels patients were lower than normal vitamin E levels patients. None of the patients with a low vitamin E level had neuropathy.

Conclusions

The type of operation performed (total vs. subtotal gastrectomy) may be the major cause of vitamin E malabsorption after gastrectomy for gastric cancer. Vitamin E deficiency probably begins within 6 months after gastrectomy for gastric cancer.

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Abbreviations

BMI:

Body mass index

WBC:

White blood cells

RBC:

Red blood cells

Hb:

Hemoglobin

Hct:

Hematocrit

Plt:

Platelets

FA:

Folic acid

TC:

Total cholesterol

TG:

Triglycerides

TP:

Total protein

Alb:

Albumin

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Disclosures

The authors declare that they have received financial support from the Fund for Grants-in-aid for Scientific Research, Ministry of Education, Culture, Sports, Science and Technology of Japan and from the Japan Society for the Promotion of Science.

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Authors and Affiliations

  1. Department of Surgery, Yokohama City University Graduate School of Medicine, 3-9, Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan

    Yasushi Rino, Norio Yukawa, Tsutomu Sato, Naoto Yamamoto, Hiroshi Tamagawa, Shinichi Hasegawa, Tsutomu Hayashi, Yosuke Atsumi & Munetaka Masuda

  2. Gastroenterological Center, Yokohama City University of Medical Center, Yokohama, Japan

    Takashi Oshima

  3. Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan

    Takaki Yoshikawa

  4. Saiseikai Yokohama Nanbu Hospital, Yokohama, Japan

    Toshio Imada

Authors
  1. Yasushi Rino
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  2. Norio Yukawa
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  3. Tsutomu Sato
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  4. Naoto Yamamoto
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  5. Hiroshi Tamagawa
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  6. Shinichi Hasegawa
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  7. Tsutomu Hayashi
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  8. Yosuke Atsumi
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  9. Takashi Oshima
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  10. Takaki Yoshikawa
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  11. Munetaka Masuda
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  12. Toshio Imada
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Corresponding author

Correspondence to Yasushi Rino.

Additional information

Supported by the Fund for Grants-in-aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan and the Japan Society for the Promotion of Science.

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Rino, Y., Yukawa, N., Sato, T. et al. Vitamin E Deficiency Begins within 6 Months after Gastrectomy for Gastric Cancer. World J Surg 38, 2065–2069 (2014). https://doi.org/10.1007/s00268-014-2515-1

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  • DOI: https://doi.org/10.1007/s00268-014-2515-1

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