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Local Platelet Trapping as the Cause of Thrombocytopenia after Hepatic Cryotherapy

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Abstract

Cryosurgery has been shown to be an effective approach to destruction of unresectable hepatic tumors. However, hepatic cryoablation may also be associated with local and systemic side effects, including thrombocytopenia and clotting dysfunction. Although thrombocytopenia is known to relate to the magnitude of hepatocellular injury, its etiology is still unknown. With the use of whole-body scintigraphy after injection of indium-111-labeled platelets we here demonstrated in six patients undergoing cryoablation of hepatic tumors that manifestation of systemic thrombocytopenia after cryosurgery is associated with excessive platelet trapping and destruction within the cryolesion. We therefore conclude that local platelet trapping represents a major cause of cryothermia-induced systemic thrombocytopenia.

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Acknowledgements

This study was supported by a grant of the “Freunde der Universitätskliniken des Saarlandes e.V.”

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Authors and Affiliations

  1. Department of Surgery, University of Saarland, D-66421, Homburg/Saar, Germany

    Georg A. Pistorius M.D., Gernot Feifel M.D. & Martin K. Schilling M.D.

  2. Department of Nuclear Medicine, University of Saarland, D-66421, Homburg/Saar, Germany

    Christof Alexander M.D. & Carl-Martin Krisch M.D.

  3. Institute for Clinical and Experimental Surgery, University of Saarland, D-66421, Homburg/Saar, Germany

    Michael D. Menger M.D.

Authors
  1. Georg A. Pistorius M.D.
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  2. Christof Alexander M.D.
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  3. Carl-Martin Krisch M.D.
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  4. Gernot Feifel M.D.
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  5. Martin K. Schilling M.D.
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  6. Michael D. Menger M.D.
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Correspondence to Georg A. Pistorius M.D..

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Pistorius, G.A., Alexander, C., Krisch, CM. et al. Local Platelet Trapping as the Cause of Thrombocytopenia after Hepatic Cryotherapy. World J. Surg. 29, 657–660 (2005). https://doi.org/10.1007/s00268-005-7543-4

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  • DOI: https://doi.org/10.1007/s00268-005-7543-4

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