Abstract
We would like to respond to the commentary with further understanding of the issue of potential statistical power in the analysis of our original finding. This further analysis has been planned to be carried out using the data from the wrinkle outcome because it has been contributed by the largest sample size with a dramatic effect size among all outcomes. Sequential analysis in this letter has been down with alpha 0.05 (type I error) and power of 0.80 (1—type II error) based on the O’Brien Fleming method. In addition to the common settings abovementioned, we chose a small effect size (SMD = 0.2) for avoiding underestimation in the optimal information size calculation and power analysis. The analysis was conducted using R via RStudio. The figure of sequential analysis shows that the cumulative effect of topical CM of stem cells on wrinkle outcome reaches statistical significance (z score of the end of blue line > 2), which is consistent with our original finding. Nevertheless, the information size of the outcome is insufficient (n = 118), which is lower than the required sample size (n = 1419). The observed power of the effects of topical CM of stem cells on the wrinkle outcome is only about 0.64, which is lower than the pre-defined or expected power of 0.80. Based on the fraction of information, although the observed z score of 3.232 for the cumulative effect surpasses 2, it does not surpass the monitoring boundary of 6.795 at the fraction (8.3%).
Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Access this article
We’re sorry, something doesn't seem to be working properly.
Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.
Reference
Atiyeh B, Emsieh S (2022) Effectiveness of topical conditioned medium of stem cells in facial skin nonsurgical resurfacing modalities for antiaging: systematic review and meta-analysis of randomized controlled trials. Aesth Plast Surgery. https://doi.org/10.1007/s00266-022-03211-z
Lin TJ, Huang YL, Kang YN, Chen C (2022) Effectiveness of topical conditioned medium of stem cells in facial skin nonsurgical resurfacing modalities for antiaging: systematic review and meta-analysis of randomized controlled trials. Aesth Plast Surgery. https://doi.org/10.1007/s00266-022-03168-z
Cohen J (2013) Statistical power analysis for the behavioral sciences. Routledge, Oxfordshire
O’Brien PC, Fleming TR (1979) A multiple testing procedure for clinical trials. Biometrics 549–556
El-Domyati M, Moftah NH, Nasif GA, Ameen SW, Ibrahim MR, Ragaie MH (2020) Facial rejuvenation using stem cell conditioned media combined with skin needling: a split-face comparative study. J Cosmet Dermatol 19(9):2404–2410. https://doi.org/10.1111/jocd.13594
Hoss E, Kollipara R, Alhaddad M, Boen M, Goldman MP (2020) Red deer umbilical cord-derived stem cell conditioned media combined with ablative resurfacing of the face. J Drugs Dermatol 19(11):1044–1048. https://doi.org/10.36849/jdd.2020.5246
Lee HJ, Lee EG, Kang S, Sung JH, Chung HM, Kim DH (2014) Efficacy of microneedling plus human stem cell conditioned medium for skin rejuvenation: a randomized, controlled, blinded split-face study. Ann Dermatol 26(5):584–591. https://doi.org/10.5021/ad.2014.26.5.584
Prakoeswa CRS, Pratiwi FD, Herwanto N, Citrashanty I, Indramaya DM, Murtiastutik D et al (2019) The effects of amniotic membrane stem cell-conditioned medium on photoaging. J Dermatol Treat 30(5):478–482. https://doi.org/10.1080/09546634.2018.1530438
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Conflict of interest
The authors declare that they have no conflicts of interest to disclose.
Human or Animal Rights
This article does not contain any studies with human participants or animals performed by any of the authors.
Informed Consent
For this type of study informed consent is not required.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Effectiveness of topical conditioned medium of stem cells in facial skin nonsurgical resurfacing modalities for antiaging: systematic review and meta analysis of randomized controlled trials.
Rights and permissions
About this article
Cite this article
Kang, YN., Chen, C. & Lin, TJ. Further Studies are Needed for Testing the Effects of Topical Conditioned Medium of Stem Cells in Facial Skin Nonsurgical Resurfacing Modalities for Antiaging. Aesth Plast Surg 48, 8–10 (2024). https://doi.org/10.1007/s00266-022-03228-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00266-022-03228-4