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Role of Cultured Skin Fibroblasts in Regenerative Dermatology

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Abstract

The skin, as the largest organ, covers the entire outer part of the body, and since this organ is directly exposed to microbial, thermal, mechanical and chemical damage, it may be destroyed by factors such as acute trauma, chronic wounds or even surgical interventions. Cell therapy is one of the most important procedures to treat skin lesions. Fibroblasts are cells that are responsible for the synthesis of collagen, elastin, and the organization of extracellular matrix (ECM) components and have many vital functions in wound healing processes. Today, cultured autologous fibroblasts are used to treat wrinkles, scars, wounds and subcutaneous atrophy. The results of many studies have shown that fibroblasts can be effective and beneficial in the treatment of skin lesions. On the other hand, skin substitutes are used as a regenerative model to improve and regenerate the skin. The use of these alternatives, restorative medicine and therapeutic cells such as fibroblasts has tremendous potential in the treatment of skin diseases and can be a new window for the treatment of diseases with no definitive treatment.

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Funding

This study was funded by Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.

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Authors and Affiliations

  1. Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran

    Mohammad Ali Nilforoushzadeh, Hamideh Afzali, Mohammad Amir Amirkhani, Amir Behtash Amiri, Nahid Nikkhah & Sona Zare

  2. Jordan Dermatology and Hair Transplantation Center, Tehran, Iran

    Mohammad Ali Nilforoushzadeh

  3. Department of Medical Biotechnology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran

    Ebrahim Khodaverdi Darian

  4. Biotechnology Research Center, Semnan University of Medical Sciences, Semnan, Iran

    Ebrahim Khodaverdi Darian

  5. Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Mohammadreza Razzaghi

  6. Department of Tissue Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Reza Naser

  7. Forensic Medicine Specialist, Research Center of Legal Medicine Organization of Iran, Tehran, Iran

    Alimohammad Alimohammadi

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  1. Mohammad Ali Nilforoushzadeh
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  2. Ebrahim Khodaverdi Darian
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Correspondence to Sona Zare.

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Nilforoushzadeh, M.A., Khodaverdi Darian, E., Afzali, H. et al. Role of Cultured Skin Fibroblasts in Regenerative Dermatology. Aesth Plast Surg 46, 1463–1471 (2022). https://doi.org/10.1007/s00266-022-02940-5

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