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Effect of Platelet-Rich Fibrin on Fat Grafting in Animal Models: A Meta-Analysis

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  • Basic Science/Experimental
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Abstract

Background

Autologous fat grafting has been widely used in plastic and reconstructive surgery, but one of the main reasons for limiting its application is the high resorption rate. Platelet-rich fibrin (PRF) is a new generation of platelet concentrate that has recently been used to improve the survival rate of fat grafts. The purpose of this study was to evaluate the effect of PRF on fat grafting.

Methods

Animal studies in four databases (PubMed, Cochrane library, Ovid, and Wan fang database) were searched up to July 2019. A meta-analysis was performed to compare PRF + fat grafting and fat grafting alone or platelet-rich plasma (PRP) + fat grafting in animal models.

Result

Six studies with 83 animals (123 fat graftings) were included in our meta-analysis. The fat survival rate (mean difference (MD) 0.14, P < 0.00001) and the microvessel density (MVD) (standardized mean difference 4.20, P = 0.02) of the PRF + fat group were significantly higher than that of the fat alone group. There was no significant difference between the PRF + fat group and PRP + fat group in the fat survival rate (MD 0.05, P = 0.06).

Conclusion

This study found that PRF combined with fat grafting may have an effect on improving the survival rate and MVD of fat grafts. However, when comparing the effects of PRF and PRP on the fat survival rate, there is currently no clear evidence to prove the difference between them. More preclinical and clinical studies are necessary to further clarify the effect of PRF on fat grafting in humans.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (81460296), National Natural Science Foundation of China (81860343), National Natural Science Foundation of China (81860348).

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Authors and Affiliations

  1. Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China

    Ruiquan Liu

  2. School of Medicine, Tsinghua University, Beijing, People’s Republic of China

    Yi Long

  3. Department of Plastic Surgery, The First Affiliated Hospital, Kunming Medical University, 295 Xichang Road, Kunming, Yunnan, 650032, People’s Republic of China

    Liu Liu & Xian Zhao

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  1. Ruiquan Liu
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Correspondence to Xian Zhao.

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Liu, R., Long, Y., Liu, L. et al. Effect of Platelet-Rich Fibrin on Fat Grafting in Animal Models: A Meta-Analysis. Aesth Plast Surg 44, 570–578 (2020). https://doi.org/10.1007/s00266-019-01563-7

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  • DOI: https://doi.org/10.1007/s00266-019-01563-7

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