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Generative Surgery of Cultured Autologous Auricular Chondrocytes for Nasal Augmentation

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Abstract

Background

Conventional treatment for nasal augmentation utilizes autologous grafts, allografts, or synthetic implants such as silicon implants. Silicon implants could protrude/expose or induce nasal bone resorption. Autologous grafts are usually associated with donor site morbidity and the volume of harvested tissue is limited. We had developed a new method for nasal augmentation using cultured autologous chondrocytes (CAC). The current report presents the results of a study using that method with a larger number of patients and an improved graft technique for the nasal tip.

Methods

Approximately 1 cm2 of cartilage was harvested from the auricular concha and treated with collagenase, and then chondrocytes were obtained. In our multilayer culture system the chondrocytes formed immature cartilaginous tissues with a gelatinous chondroid matrix. They were injection-grafted into the subcutaneous pocket of the nasal dorsum.

Results

The chondrocytes with a gelatinous chondroid matrix change from a soft gel to hard neocartilage tissue within 2 to 3 weeks and then stabilize. The authors have used this procedure over a 6-year period on 75 cases: 58 secondary augmentation rhinoplasties following silicon implantation and 17 primary augmentation cases. The results have been satisfactory and long-lasting.

Conclusion

Grafting of CAC is an optional method for nasal augmentation and could be used for a wide range of facial augmentation cases.

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Authors and Affiliations

  1. Yanaga Clinic and Tissue Culture Laboratory, 1-4-6, Kumamoto, Kokura-Kita-Ku, Kitakyushu, Fukuoka, 802-0044, Japan

    Hiroko Yanaga & Katsu Yanaga

  2. Division of Plastic Surgery, Osaka City General Hospital, 2-13-22, Miyakojima-hondori, Miyakojima-ku, Osaka, 534-0021, Japan

    Keisuke Imai

Authors
  1. Hiroko Yanaga
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  2. Keisuke Imai
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  3. Katsu Yanaga
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Correspondence to Hiroko Yanaga.

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Yanaga, H., Imai, K. & Yanaga, K. Generative Surgery of Cultured Autologous Auricular Chondrocytes for Nasal Augmentation. Aesth Plast Surg 33, 795–802 (2009). https://doi.org/10.1007/s00266-009-9399-8

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  • DOI: https://doi.org/10.1007/s00266-009-9399-8

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