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Orthobiologics: a review

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Abstract

Purpose

The use of biologic materials in orthopaedics (orthobiologics) has gained significant attention over the past years. To enhance the body of the related literature, this review article is aimed at summarizing these novel biologic therapies in orthopaedics and at discussing their multiple clinical implementations and outcomes.

Methods

This review of the literature presents the methods, clinical applications, impact, cost-effectiveness, and outcomes, as well as the current indications and future perspectives of orthobiologics, namely, platelet-rich plasma, mesenchymal stem cells, bone marrow aspirate concentrate, growth factors, and tissue engineering.

Results

Currently available studies have used variable methods of research including biologic materials as well as patient populations and outcome measurements, therefore making comparison of studies difficult. Key features for the study and use of orthobiologics include minimal invasiveness, great healing potential, and reasonable cost as a nonoperative treatment option. Their clinical applications have been described for common orthopaedic pathologies such as osteoarthritis, articular cartilage defects, bone defects and fracture nonunions, ligament injuries, and tendinopathies.

Conclusions

Orthobiologics-based therapies have shown noticeable clinical results at the short- and mid-term. It is crucial that these therapies remain effective and stable in the long term. The optimal design for a successful scaffold remains to be further determined.

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Data availability

Data (review of the literature) are available in a data repository.

Code availability

Not applicable.

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  1. First Department of OrthopaedicsNational and Kapodistrian University of Athens, School of Medicine, Athens, Greece

    Andreas F. Mavrogenis, Vasileios Karampikas, Alexandros Zikopoulos, Spyridon Sioutis, Dimitrios Mastrokalos & Dimitrios Koulalis

  2. Clinique Chirurgicale St. Michel, Groupe ELSAN, Toulon, France

    Marius M. Scarlat

  3. Henri Mondor Hospital, University Paris, Créteil, France

    Philippe Hernigou

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Mavrogenis, A.F., Karampikas, V., Zikopoulos, A. et al. Orthobiologics: a review. International Orthopaedics (SICOT) 47, 1645–1662 (2023). https://doi.org/10.1007/s00264-023-05803-z

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