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Patient characteristics differently affect early cup and stem loosening in THA: a case-control study on 7,535 patients

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Abstract

We postulated that certain patient characteristics have different effects on early THA component loosening. With two matched case-control studies we assessed 3,028 cups and 5,224 stems. Loosening was defined using signs of mechanical component failure on routine follow-up radiographs or revision for aseptic loosening. Women and men had similar cup-loosening odds, but women had lower odds for stem loosening (p < 0.0001). Odds for cup loosening decreased by 2.1% per additional year of age (p = 0.0004), those for stem loosening by 2.4% (p < 0.0001). Each additional kilogram of weight decreased cup loosening odds by 1.3% (p = 0.0051). Each additional unit of BMI increased stem loosening odds (p = 0.0109). Charnley classes B and C were protective factors against loosening of both components. There were no risk differences for the various main diagnoses. Certain patient characteristics differently affected early cup and stem loosening, although some characteristics had the same protective or harmful effect on component survival.

Résumé

IO-10-06-555.R1. A partir de l’hypothèse que certaines caractéristiques des patients avaient un effet sur les descellements précoces des prothèses de la hanche, nous avons étudié 3028 cupules et 5224 tiges fémorales dans le cadre d’une étude controlée. Le descellement a été défini par des anomalies radiographiques ou l’existence d’une reprise pour descellement aseptique. Les hommes et les femmes avaient un taux similaire de descellement cotyloidien mais les femmes avaient un taux de descellement de tige plus faible (p<0,0001). La fréquence des descellements cotyloidiens diminuait de 2,1% par année d’âge (p=0,0004), et celle des descellements de tige de 2,4% (p<0,0001). Chaque kilog de poids supplémentaire diminuait de 1,3% les descellements cotyloidiens (p=0,0051). Chaque unité supplémentaire de BMI augmentait le descellement de la tige (p=0,0109).Les classes B et C de Charnley étaient des facteurs protecteurs du descellements des deux composants.. Il n’y avait pas de différence de risque entre les principaux diagnostics. Les caractéristiques des patients affectent de façon différente les descellements précoces et certaines caractéristiques sont protectrices ou nuisibles vis à vis de la survie des composants.

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Authors and Affiliations

  1. MEM Research Center in Orthopaedic Surgery, Institute for Evaluative Research in Orthopaedic Surgery, University of Bern, Stauffacherstrasse 78, 3014, Bern, Switzerland

    C. Röder, P. Münger, M. Melloh & A. Busato

  2. Department of Orthopaedic Surgery, Inselspital, University of Bern, 3001, Bern, Switzerland

    S. Eggli

  3. Health Technology Assessment and Clinical Epidemiology, MEM Research Center in Orthopaedic Surgery, Institute for Evaluative Research in Orthopaedic Surgery, University of Bern, Stauffacherstrasse 78, 3014, Bern, Switzerland

    A. Busato

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  1. C. Röder
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  2. S. Eggli
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  3. P. Münger
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  4. M. Melloh
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  5. A. Busato
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Correspondence to C. Röder.

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Röder, C., Eggli, S., Münger, P. et al. Patient characteristics differently affect early cup and stem loosening in THA: a case-control study on 7,535 patients. International Orthopaedics (SICO 32, 33–38 (2008). https://doi.org/10.1007/s00264-006-0291-8

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  • DOI: https://doi.org/10.1007/s00264-006-0291-8

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