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Celiac plexus block combined with 125I seeds for refractory epigastric pain from abdominal malignancies: a retrospective case–control study

  • Interventional Radiology
  • Published:
Abdominal Radiology Aims and scope Submit manuscript

Abstract

Purpose

To evaluate the clinical efficacy of celiac plexus block (CPB) combined with 125I seeds implantation (ISI) for refractory epigastric pain from abdominal malignancies.

Methods

The data of 81 patients with refractory epigastric pain [visual analog scale (VAS) score ≥ 4] from abdominal malignancies were collected in this retrospective case–control study. Group A (n = 40) was treated with CPB alone, while Group B (n = 41) underwent CPB combined with ISI. The primary study endpoints were the VAS score, quality of life (QoL), and local tumor control (LTC) rate. The secondary endpoints were complications, progression-free survival (PFS), and overall survival (OS).

Results

The VAS scores at week 2 (T2), week 4 (T4), week 8 (T8), and week 12 (T12) in both groups were significantly lower compared with the pretreatment values (all P < 0.01). VAS scores in Group B showed a sustained decrease, especially for “mild pain” and “moderate pain,” while the VAS scores in Group A rebounded at T8 and T12 (both P < 0.01). The QoL in Group B improved significantly from T4 until T12, which better than that at T12 in Group A (all P < 0.01). The LTC rates at T8 were 35.0% and 92.7% in Groups A and B, respectively, with a significant difference (P < 0.01). Group B had a slightly lower complication rate and a slightly longer median PFS/OS than group A, but neither was statistically different (P = 0.09 and P = 0.99, respectively).

Conclusion

CPB combined with ISI performs more sustained pain relief (up to 12 weeks) compared to CPB alone, and ultimately improves the patients’ QoL.

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Data availability

In addition to the raw data in the manuscript, the datasets used are available from the corresponding author on Availability of data and materials.

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Funding

This study was funded by the Major science and technology projects of Henan Province in 2022 [grant numbers 221100310100].

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Authors and Affiliations

  1. Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Zhengzhou, 450052, China

    Yiming Liu, Chengzhi Zhang, Mengyao Song, Kaihao Xu, Xinwei Han & Dechao Jiao

Authors
  1. Yiming Liu
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  2. Chengzhi Zhang
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  3. Mengyao Song
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  4. Kaihao Xu
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  5. Xinwei Han
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  6. Dechao Jiao
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by YL, CZ, and DJ. The first draft of the manuscript was written by YL and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Dechao Jiao.

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Conflict of interest

The authors have no competing interests to declare that are relevant to the content of this article.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the Ethics Committees of the First Affiliated Hospital of Zhengzhou University.

Informed consent

The requirement for informed consent was waived by the Ethics Committee of The First Affiliated Hospital of Zhengzhou University because of the retrospective nature of the study.

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Liu, Y., Zhang, C., Song, M. et al. Celiac plexus block combined with 125I seeds for refractory epigastric pain from abdominal malignancies: a retrospective case–control study. Abdom Radiol 48, 2157–2166 (2023). https://doi.org/10.1007/s00261-023-03905-1

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