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Diffusion kurtosis imaging and MRI-detected extramural venous invasion in rectal cancer: correlation with clinicopathological prognostic factors

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Abstract

Objective

To investigate the prognostic value of the diffusion kurtosis imaging (DKI)-derived parameters D value, K value, diffusion-weighted imaging (DWI) parameter apparent diffusion coefficient (ADC) value, and magnetic resonance imaging (MRI)-detected extramural venous invasion (EMVI) (mrEMVI) in rectal cancer patients.

Methods

Forty patients who underwent MRI for rectal cancer were retrospectively evaluated. DKI-derived parameters D and K were measured using the Medical Imaging Interaction Toolkit. Conventional ADC values were measured from the corresponding DWI images. An experienced radiologist evaluated the mrEMVI status on MR images using the mrEMVI scoring system. An independent sample t-test or analysis of variance was used to analyze and compare the measurement data. The x2 test or Fisher exact test was used for categorical variables. Receiver operating characteristic curves were used to assess the diagnostic performance of these parameters.

Results

Among the 40 patients, MRI showed positive EMVI in 15 patients and negative EMVI in 25 patients. Positive mrEMVI status was associated with age, positive circumferential resection margin, pT-stage, lymphovascular invasion (LVI), distant metastasis, and serum carcinoembryonic antigen (CEA) level (P = 0.004–0.036). The dispersion coefficient (D) values and ADC values were significantly higher in the mucinous adenocarcinoma (MC) group than in the common adenocarcinoma (AC) group (P = 0.001), while kurtosis coefficient (K) values were lower in the MC group than in the AC group (P = 0.022). D values were significantly higher in the KRAS-mutated group than in the wild-type group (P < 0.05), whereas K values were lower in the KRAS-mutated group than in the wild-type group (P < 0.05). All three parameters (D, K, and ADC values) showed good diagnostic performance for discriminating MC from AC. Both the D and K values showed certain diagnostic performance for discriminating KRAS mutation.

Conclusion

DKI-derived parameters, conventional ADC values, and mrEMVI are associated with different histopathological prognostic factors. All DKI-derived parameters and conventional ADC values may distinguish MC from AC. DKI-derived parameters may also be used to discriminate KRAS mutation.

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Data availability

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Author notes

  1. Cui Tang and Gaixia Lu have contributed equally to this work.

Authors and Affiliations

  1. Department of Radiology Medicine, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, 200090, China

    Cui Tang, Jinming Xu, Jie Kuang & Jinlei Xu

  2. Department of Nuclear Medicine, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200072, China

    Gaixia Lu

  3. Department of Radiology Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China

    Peijun Wang

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  1. Cui Tang
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Contributions

CT and PJW contributed to the study conception and design. All authors collected the data and performed the data analysis. All authors contributed to the interpretation of the data and the completion of figures and tables. All authors contributed to the drafting of the article and final approval of the submitted version.

Corresponding author

Correspondence to Peijun Wang.

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All the authors declare that they have no competing interests.

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This retrospective study was approved by the ethics committee of Yangpu Hospital of Tongji University (Shanghai, China).

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The requirement for informed patient consent was waived.

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Tang, C., Lu, G., Xu, J. et al. Diffusion kurtosis imaging and MRI-detected extramural venous invasion in rectal cancer: correlation with clinicopathological prognostic factors. Abdom Radiol 48, 844–854 (2023). https://doi.org/10.1007/s00261-022-03782-0

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