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Eosinophilic solid and cystic renal cell carcinoma: a review of literature focused on radiological findings and differential diagnosis

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Abstract

Eosinophilic solid and cystic renal cell carcinoma (ESC-RCC) is a rare type of renal cell carcinoma with inert biological behavior that has not yet been included in the 2016 World Health Organization (WHO) classification, and its imaging manifestations are unclear due to its rarity. Although there have only been a few cases, the CT and MRI findings of ESC-RCC are characterized by its cystic solid structure, according to the proportion of cystic and solid components observed on images, ESC-RCC can be categorized into three types. Especially the Type I, when the cystic-solid components are almost equal, the imaging findings are illustrated as “lotus root-like,” which may be helpful in the differential diagnosis of ESC-RCC from other types of renal tumors. In fact, ESC-RCC has diverse radiological appearances, and the differentiation of clear cell renal cell carcinoma, renal oncocytoma, chromophobe renal cell carcinoma, and renal angiomyolipoma remains challenging. This review aims to discuss ESC-RCC with a focus on the radiological findings and differential diagnosis of ESC-RCC.

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Abbreviations

CT:

Computed tomography

ESC-RCC:

Eosinophilic solid and cystic renal cell carcinoma

GUPS:

The Genitourinary Pathology Society

MRI:

Magnetic resonance imaging

RCC:

Renal cell carcinoma

TSC:

Tuberous sclerosis complex

WHO:

World Health Organization

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Funding

No funding was received for this study.

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Author notes

  1. Ji Lu and Yufei Liu both have contributed equally to this work.

Authors and Affiliations

  1. Department of Radiology, The First College of Clinical Medical Science of China, Three Gorges University and Yichang Central People’s Hospital, No. 183, Yiling Avenue, Yichang, 443000, China

    Minghui Yi, Shuni Wang, Peng Wang & Ji Lu

  2. Department of Radiology, Zhongxiang People’s Hospital, No. 19, Xiangyun Avenue, Zhongxiang, 431900, China

    Zhaoyang Wang

  3. Department of Pathology, The First College of Clinical Medical Science of China, Three Gorges University and Yichang Central People’s Hospital, No. 183, Yiling Avenue, Yichang, 443000, China

    Yufei Liu

Authors
  1. Minghui Yi
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  2. Shuni Wang
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  3. Peng Wang
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  4. Zhaoyang Wang
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  5. Ji Lu
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Contributions

Conceptualization: JL and YL; Data collection and formal analysis: SW, PW, and ZW; literature search and writing—original draft preparation: MY; writing—review and editing: JL. All authors read and approved the final manuscript.

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Correspondence to Ji Lu.

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All procedures performed in studies involving human participants were conducted in accordance with ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. For a study of this type, formal consent is not required.

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Yi, M., Wang, S., Wang, P. et al. Eosinophilic solid and cystic renal cell carcinoma: a review of literature focused on radiological findings and differential diagnosis. Abdom Radiol 48, 350–357 (2023). https://doi.org/10.1007/s00261-022-03694-z

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  • DOI: https://doi.org/10.1007/s00261-022-03694-z

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