Abstract
Abdominal radiologists perform a wide variety of image-guided interventions. Procedures performed by abdominal radiologists can be broadly categorized into paracentesis, thoracentesis, superficial and deep soft tissue biopsy, drain placement, and ablation. As these procedures continue to develop as an alternative to more invasive and potentially morbid interventions, and with continued improvements in minimally invasive technologies, it becomes increasingly important for abdominal radiologists to be familiar with options for peri-procedural analgesia and anxiolysis, as well as when to consult anesthesiology. In this review, we discuss analgesic, anxiolytic, and nonpharmacologic options available to the abdominal radiologist. We focus on practical agents that are relatively safe for general use, special populations, and considerations for post-procedural monitoring.
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References
Rosenkrantz AB, Friedberg EB, Prologo JD, Everett C, Duszak R, Jr. (2018) Generalist versus Subspecialist Workforce Characteristics of Invasive Procedures Performed by Radiologists. Radiology 289:140-147.
Fananapazir G, Lubner MG, Cook PS, Brook OR (2021) Abdominal radiology involvement in image-guided procedures: a perspective from the society of abdominal radiology Cross-Sectional Interventional Radiology Emerging Technology Commission. Abdom Radiol (NY).
Raja SN, Carr DB, Cohen M, Finnerup NB, Flor H, Gibson S, Keefe FJ, Mogil JS, Ringkamp M, Sluka KA, Song XJ, Stevens B, Sullivan MD, Tutelman PR, Ushida T, Vader K (2020) The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises. Pain 161:1976-1982.
Strazar AR, Leynes PG, Lalonde DH (2013) Minimizing the pain of local anesthesia injection. Plast Reconstr Surg 132:675-684.
Dubin AE, Patapoutian A (2010) Nociceptors: the sensors of the pain pathway. J Clin Invest 120:3760-3772.
Butterworth JF, Mackey DC, Wasnick JD (2018) Morgan and Mikhail's Clinical Anesthesiology, 6th edition. McGraw-Hill Education.
(2018) Practice Guidelines for Moderate Procedural Sedation and Analgesia 2018: A Report by the American Society of Anesthesiologists Task Force on Moderate Procedural Sedation and Analgesia, the American Association of Oral and Maxillofacial Surgeons, American College of Radiology, American Dental Association, American Society of Dentist Anesthesiologists, and Society of Interventional Radiology. Anesthesiology 128:437-479.
Hatsiopoulou O, Cohen RI, Lang EV (2003) Postprocedure pain management of interventional radiology patients. J Vasc Interv Radiol 14:1373-1385.
Cashman JN, Ng L (2017) The management of peri- and postprocedural pain in interventional radiology: a narrative review. Pain Manag 7:523-535.
Andreano A, Galimberti S, Franza E, Knavel EM, Sironi S, Lee FT, Meloni MF (2014) Percutaneous microwave ablation of hepatic tumors: prospective evaluation of postablation syndrome and postprocedural pain. J Vasc Interv Radiol 25:97–105.e101–102.
Lee P, Le Saux M, Siegel R, Goyal M, Chen C, Ma Y, Meltzer AC (2019) Racial and ethnic disparities in the management of acute pain in US emergency departments: Meta-analysis and systematic review. Am J Emerg Med 37:1770-1777.
Meghani SH, Byun E, Gallagher RM (2012) Time to take stock: a meta-analysis and systematic review of analgesic treatment disparities for pain in the United States. Pain Med 13:150-174.
Mychajlowycz M, Alabousi A, Mironov O (2021) Ultrasound- Versus CT-Guided Subpleural Lung and Pleural Biopsy: An Analysis of Wait Times, Procedure Time, Safety, and Diagnostic Adequacy. Can Assoc Radiol J 72:883-889.
Johnson S (2010) Sedation and analgesia in the performance of interventional procedures. Semin Intervent Radiol 27:368-373.
Becker DE, Reed KL (2012) Local anesthetics: review of pharmacological considerations. Anesth Prog 59:90–101; quiz 102–103.
Schoenmakers KP, Fenten MG, Louwerens JW, Scheffer GJ, Stienstra R (2015) The effects of adding epinephrine to ropivacaine for popliteal nerve block on the duration of postoperative analgesia: a randomized controlled trial. BMC Anesthesiol 15:100.
Zilinsky I, Bar-Meir E, Zaslansky R, Mendes D, Winkler E, Orenstein A (2005) Ten commandments for minimal pain during administration of local anesthetics. J Drugs Dermatol 4:212-216.
Christoph RA, Buchanan L, Begalla K, Schwartz S (1988) Pain reduction in local anesthetic administration through pH buffering. Ann Emerg Med 17:117-120.
Masters JE (1998) Randomised control trial of pH buffered lignocaine with adrenaline in outpatient operations. Br J Plast Surg 51:385-387.
Arndt KA, Burton C, Noe JM (1983) Minimizing the pain of local anesthesia. Plast Reconstr Surg 72:676-679.
Quaba O, Huntley JS, Bahia H, McKeown DW (2005) A users guide for reducing the pain of local anaesthetic administration. Emerg Med J 22:188-189.
Cepeda MS, Carr DB, Miranda N, Diaz A, Silva C, Morales O (2005) Comparison of morphine, ketorolac, and their combination for postoperative pain: results from a large, randomized, double-blind trial. Anesthesiology 103:1225-1232.
Smith HS (2011) Perioperative intravenous acetaminophen and NSAIDs. Pain Med 12:961-981.
De Oliveira GS, Jr., Agarwal D, Benzon HT (2012) Perioperative single dose ketorolac to prevent postoperative pain: a meta-analysis of randomized trials. Anesth Analg 114:424-433.
Patel IJ, Rahim S, Davidson JC, Hanks SE, Tam AL, Walker TG, Wilkins LR, Sarode R, Weinberg I (2019) Society of Interventional Radiology Consensus Guidelines for the Periprocedural Management of Thrombotic and Bleeding Risk in Patients Undergoing Percutaneous Image-Guided Interventions-Part II: Recommendations: Endorsed by the Canadian Association for Interventional Radiology and the Cardiovascular and Interventional Radiological Society of Europe. J Vasc Interv Radiol 30:1168-1184.e1161.
Griffin CE, 3rd, Kaye AM, Bueno FR, Kaye AD (2013) Benzodiazepine pharmacology and central nervous system-mediated effects. Ochsner J 13:214-223.
Barash PG (2009) Clinical Anesthesia. Wolters Kluwer/Lippincott Williams & Wilkins.
Moran TC, Kaye AD, Mai AH, Bok LR (2013) Sedation, analgesia, and local anesthesia: a review for general and interventional radiologists. Radiographics 33:E47-60.
(2002) Practice guidelines for sedation and analgesia by non-anesthesiologists. Anesthesiology 96:1004–1017.
Makary MS, da Silva A, Kingsbury J, Bozer J, Dowell JD, Nguyen XV (2020) Noninvasive Approaches for Anxiety Reduction During Interventional Radiology Procedures. Top Magn Reson Imaging 29:197-201.
Lang EV, Berbaum KS (1997) Educating interventional radiology personnel in nonpharmacologic analgesia: effect on patients' pain perception. Acad Radiol 4:753-757.
Bertrand AS, Iannessi A, Buteau S, Jiang XY, Beaumont H, Grondin B, Baudin G (2018) Effects of relaxing therapies on patient's pain during percutaneous interventional radiology procedures. Ann Palliat Med 7:455-462.
Bina B, Hersh EV, Hilario M, Alvarez K, McLaughlin B (2018) True Allergy to Amide Local Anesthetics: A Review and Case Presentation. Anesth Prog 65:119-123.
Pavlidakey PG, Brodell EE, Helms SE (2009) Diphenhydramine as an alternative local anesthetic agent. J Clin Aesthet Dermatol 2:37-40.
Dire DJ, Hogan DE (1993) Double-blinded comparison of diphenhydramine versus lidocaine as a local anesthetic. Ann Emerg Med 22:1419-1422.
Green SM, Rothrock SG, Gorchynski J (1994) Validation of diphenhydramine as a dermal local anesthetic. Ann Emerg Med 23:1284-1289.
Pickett LE, Macdonald J (2017) Injectable Diphenhydramine Used as Anaesthetic for Wide Local Excision With Flap Closure. J Cutan Med Surg 21:256-257.
Farrell C, McConaghy P (2012) Perioperative management of patients taking treatment for chronic pain. Bmj 345:e4148.
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All authors contributed equally to the literature search for this article. GF originated the idea, AS wrote the primary manuscript, ND offered expertise and editing of the manuscript, and KC provided expertise and writing regarding pharmacotherapy and created Table 1. All authors commented on previous versions of the manuscript and approved the final version.
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Shah, A., Cohen, K., Patel, B. et al. Optimizing anxiolysis and analgesia for percutaneous intervention by the abdominal radiologist. Abdom Radiol 47, 2721–2729 (2022). https://doi.org/10.1007/s00261-022-03417-4
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DOI: https://doi.org/10.1007/s00261-022-03417-4