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Pancreatic extracellular volume fraction using T1 mapping in patients with impaired glucose intolerance

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Abstract

Purpose

To evaluate pancreatic T1 mapping and extracellular volume (ECV) fraction’s feasibility to assess impaired glucose tolerance (IGT) patients.

Methods

A total of 45 consecutive patients with known or suspected pancreatic disease underwent contrast-enhanced magnetic resonance (MR) imaging, including T1 mapping, using saturation recovery sequence. Patients were classified into three groups based on the American Diabetes Association criteria: no-diabetes subjects, HbA1c < 5.7%; pre-diabetes, 5.7% ≤ HbA1c < 6.5%; and type 2 diabetes mellitus (T2DM), HbA1c ≥ 6.5%. Pre-contrast pancreatic T1 value and ECV of the pancreas were computed, and then pre-contrast pancreatic T1 value, ECV and HbA1c values were compared. The present prospective study was approved by our institutional review board. Written informed consent was obtained from all patients.

Results

A positive correlation between HbA1c values and both pre-contrast pancreatic T1 value and ECV (r = 0.79, P < 0.001 and r = 0.60, P < 0.001, respectively) were observed. The pre-contrast pancreatic T1 value and ECV were significantly higher in T2DM vs. no-diabetes subjects and pre-diabetes (P < 0.001). No significant difference between two qualitative values (P = 0.14) was found, however, the sensitivity, specificity, and area under the receiver-operating-characteristic curve differentiating no-diabetes subjects and pre-diabetes from T2DM were superior in ECV (100%, 93.5%, and 0.990) vs. pre-contrast pancreatic T1 values (84.6%, 96.8%, and 0.906).

Conclusions

The ECV of the pancreas could serve as a potential imaging biomarker for the assessment of pancreatic fibrosis leading to IGT.

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Authors and Affiliations

  1. Department of Radiology, Gifu University, 1-1 Yanagido, Gifu, 501-1194, Japan

    Yoshifumi Noda, Kimihiro Kajita, Nobuyuki Kawai, Hiroshi Kawada, Yukichi Tanahashi & Masayuki Matsuo

  2. Department of Diagnostic Radiology & Nuclear Medicine, Hamamatsu University, Hamamatsu, Japan

    Satoshi Goshima

  3. Department of Radiology, Kyoto Prefectural University of Medicine, Kyoto, Japan

    Yusuke Tsuji

  4. Philips Japan, Tokyo, Japan

    Yuta Akamine

Authors
  1. Yoshifumi Noda
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  2. Satoshi Goshima
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  3. Yusuke Tsuji
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  4. Kimihiro Kajita
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  5. Yuta Akamine
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  6. Nobuyuki Kawai
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  7. Hiroshi Kawada
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  8. Yukichi Tanahashi
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  9. Masayuki Matsuo
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Corresponding author

Correspondence to Yoshifumi Noda.

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All authors declare that they have no conflicts of interest to disclose.

Research involving human participants and/or animals

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This prospective study was approved by our Institutional Review Board, and a written informed consent was obtained from all patients.

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The requirement for informed consent was obtained from all patients.

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Noda, Y., Goshima, S., Tsuji, Y. et al. Pancreatic extracellular volume fraction using T1 mapping in patients with impaired glucose intolerance. Abdom Radiol 45, 449–456 (2020). https://doi.org/10.1007/s00261-019-02384-7

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  • DOI: https://doi.org/10.1007/s00261-019-02384-7

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