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Comparison of parallel and crossed placement of antennas in microwave ablation of 3–5 cm hepatocellular carcinoma

  • Hepatobiliary
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Abstract

Purpose

To evaluate the effects of ablation strategies on local tumor progression (LTP) after microwave ablation (MWA) of hepatocellular carcinomas (HCCs) measuring 3–5 cm.

Materials and methods

Between December 2011 and May 2017, 71 HCC patients with 71 nodules treated by ultrasound(US)-guided percutaneous MWA were divided into parallel (group A) and crossed (group B) antenna placement groups. All patients underwent MWA using two antennas with four insertions. LTP and overall survival (OS) rates were compared between the two groups.

Results

The median follow-up time was 16.8 months. There was no significant difference in the complete ablation rate and treatment sessions between the two groups. LTP was diagnosed in 8 of 48 nodules (16.7%) in group A and 1 of 23 nodules (4.3%) in group B, with no significant difference between two groups (P = 0.115). The 1-, 2-, and 3-year OS rates were 88.5%, 79%, and 71.8% in group A and 93.8%, 87.5%, and 87.5% in group B, respectively (P = 0.236). Multivariate analysis showed that the tumor diameter (P = 0.017), the distance between the antennas (P = 0.032), and the total emission time (P = 0.015) were associated with LTP.

Conclusions

There were trends with lower LTP and improved OS in group B, despite the lack of statistically significant differences between the two strategies at a level of P < 0.05. The increase of distance between antennas and total emission time will facilitate reductions in LTP rate.

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Acknowledgements

This work was supported by three Grants: [2017YFC0112000] from National Key R&D Program of China, and [81627803, 81671710, 81471683, and 81622024] from the national nature science foundation of China.

Funding

This work was supported by the National Key R&D Program of China (2017YFC0112000), and the National Natural Scientific Foundation of China (81627803, 81622024, 81671710, and 81471683).

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Author notes

  1. Jie Yu and Ping Liang have contributed equally to this work.

Authors and Affiliations

  1. Department of Interventional Ultrasound, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China

    Li-nan Dong, Xiao-ling Yu, Zhi-gang Cheng, Zhi-yu Han, Fang-yi Liu, Gang Chen, Yan-chun Luo, Jie Yu & Ping Liang

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  1. Li-nan Dong
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  2. Xiao-ling Yu
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Correspondence to Jie Yu or Ping Liang.

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Dong, Ln., Yu, Xl., Cheng, Zg. et al. Comparison of parallel and crossed placement of antennas in microwave ablation of 3–5 cm hepatocellular carcinoma. Abdom Radiol 44, 2293–2300 (2019). https://doi.org/10.1007/s00261-019-01959-8

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