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Comparison of 10- and 20-min hepatobiliary phase images on Gd-EOB-DTPA-enhanced MRI T1 mapping for liver function assessment in clinic

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Abstract

Purpose

To compare hepatobiliary phase (HBP) images obtained 10 and 20 min after Gd-EOB-DTPA-enhanced MRI for liver function assessment in clinic on 3.0 T MR imaging.

Methods

103 patients were separated into four groups: 38 patients for the normal liver function (NLF) group, 33 patients for the liver cirrhosis with Child–Pugh A (LCA) group, 21 patients for the liver cirrhosis with Child–Pugh B group, and 11 patients for a liver cirrhosis with Child–Pugh C group. T1 relaxation times (T1rt) were measured on T1 mapping and reduction rates of T1rt (rrT1rt) were calculated. HBP images were obtained at the 10- and 20-min mark after Gd-EOB-DTPA enhancement.

Results

T1rt on pre-enhancement imaging showed no significant difference (p > 0.05) among all four groups. T1rt for both the 10-min HBP and the 20-min HBP showed a significant difference (p < 0.05) among all groups, but showed no significant difference (p > 0.05) between the NLF group and the LCA group. T1rt and rrT1rt showed no significant difference (p > 0.05) between 10-min HBP and 20-min HBP among all groups. The ROC analysis on 10-min HBP and 20-min HBP showed a lower diagnostic performance between NLF group and LCA group (AUC from 0.532 to 0.582), but high diagnostic performance (AUC from 0.788 to 1.000) among others group.

Conclusions

In comparing 10-min HBP and 20-min HBP T1 mapping after Gd-EOB-DTPA enhancement, our results suggest that 10-min HBP T1 mapping is a feasible option for quantitatively assessing liver function.

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Abbreviations

AUC:

Area under the curve

CNR:

Contrast-to-noise ratio

Gd-EOB-DTPA:

Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid

HBP:

Hepatobiliary phase

MRI:

Magnetic resonance imaging

MELD:

Model for end-stage liver disease

ROC:

Receiver operating characteristic

ROI:

Region of interest

rrT1rt:

Reduction rate of T1 relaxation time

SI:

Signal intensity

SNR:

Signal-to-noise ratio

T1rt:

T1 relaxation time

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Acknowledgements

Thanks for Dr. Kyongtae Bae and Dr. Cheng Tao from University of Pittsburgh Medical Centre for giving comments.

Author information

Authors and Affiliations

  1. Department of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, People’s Republic of China

    Zhi-Peng Zhou, Li-Ling Long, Li-Juan Huang, Teng-Fei Yang & Zhong-Kui Huang

  2. Department of Radiology, Affiliated Hospital of Guilin Medical University, Guilin, 541001, Guangxi, People’s Republic of China

    Zhi-Peng Zhou, Wei-Jia Qiu & Ge Cheng

Authors
  1. Zhi-Peng Zhou
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  2. Li-Ling Long
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  3. Wei-Jia Qiu
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  4. Ge Cheng
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  5. Li-Juan Huang
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  6. Teng-Fei Yang
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  7. Zhong-Kui Huang
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Corresponding author

Correspondence to Zhong-Kui Huang.

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Funding

This study was funded by the National Natural Science Foundation of China (Grant No. 81260214), the State Key Program of Health Care of Guangxi (Grant No. 2012080), and the Innovation Project of Guangxi Graduate Education (Grant No. YCBZ2015029).

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Zhou, ZP., Long, LL., Qiu, WJ. et al. Comparison of 10- and 20-min hepatobiliary phase images on Gd-EOB-DTPA-enhanced MRI T1 mapping for liver function assessment in clinic. Abdom Radiol 42, 2272–2278 (2017). https://doi.org/10.1007/s00261-017-1143-2

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  • DOI: https://doi.org/10.1007/s00261-017-1143-2

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