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MR–PET co-registration in upper abdominal imaging: quantitative comparison of two different T1-weighted gradient echo sequences: initial observations

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Abstract

Purpose

The purpose of this study is to quantitatively compare the accuracy of spatial registration of Cartesian breath-hold 3D-GRE and non-respiratory-triggered free-breathing radial 3D-GRE images with PET data acquisition on whole-body hybrid MR–PET system.

Materials and methods

Eight patients (six men and two women; mean age, 56.6 ± 5.5 years) with nine ablated hepatocellular carcinomas constituted our study population. Spatial coordinates (x, y, z) of the estimated isocenters of the ablated areas were independently determined by two radiologists. Both T1-weighted sequences were performed in the axial plane. Distance between the isocenter of the lesion on PET images and on both T1-weighted images was measured, and misregistration was calculated. Statistical analysis was performed using Student t test.

Results

Misalignment values of the hepatic ablation zones between PET and MR images were calculated at 4.94 ± 1.35 mm (reader 1) and 4.89 ± 2.21 mm (reader 2) for Cartesian 3D-GRE sequence, and 2.48 ± 0.65 mm (reader 1) and 2.72 ± 0.44 mm (reader 2) for the radial 3D-GRE sequence, with p values of 0.0011 and 0.0133, respectively.

Conclusion

Radial 3D-GRE offers improved registration accuracy with PET, supporting the use of this T1-weighted sequence in upper abdominal MR–PET studies.

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References

  1. Osman MM, Cohade C, Nakamoto Y, et al. (2003) Clinically significant inaccurate localization of lesions with PET/CT: frequency in 300 patients. J Nucl Med 44:240–243

    PubMed  Google Scholar 

  2. Seppenwoolde Y, Shirato H, Kitamura K, et al. (2002) Precise and real-time measurement of 3D tumor motion in lung due to breathing and heartbeat, measured during radiotherapy. Int J Radiat Oncol Biol Phys 53:822–834

    Article  PubMed  Google Scholar 

  3. Nakamoto Y, Chin BB, Cohade C, et al. (2004) PET/CT: artifacts caused by bowel motion. Nucl Med Commun 25:221–225

    Article  PubMed  Google Scholar 

  4. Erdi YE, Nehmeh SA, Pan T, et al. (2004) The CT motion quantitation of lung lesions and its impact on PET-measured SUVs. J Nucl Med 45:1287–1292

    PubMed  Google Scholar 

  5. Guerin B, Cho S, Chun SY, et al. (2011) Nonrigid PET motion compensation in the lower abdomen using simultaneous tagged-MRI and PET imaging. Med Phys 38:3025–3038

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  6. Cohade C, Osman M, Marshall LNT, Wahl RNTL (2003) PET-CT: accuracy of PET and CT spatial registration of lung lesions. Eur J Nucl Med Mol Imaging 30:721–726. doi:10.1007/s00259-002-1055-3

    Article  PubMed  Google Scholar 

  7. Wurslin C, Schmidt H, Martirosian P, et al. (2013) Respiratory motion correction in oncologic PET using T1-weighted MR imaging on a simultaneous whole-body PET/MR system. J Nucl Med 54:464–471. doi:10.2967/jnumed.112.105296

    Article  PubMed  Google Scholar 

  8. Rofsky NM, Lee VS, Laub G, et al. (1999) Abdominal MR imaging with a volumetric interpolated breath-hold examination. Radiology 212:876–884. doi:10.1148/radiology.212.3.r99se34876

    Article  CAS  PubMed  Google Scholar 

  9. Reiner CS, Neville AM, Nazeer HK, et al. (2013) Contrast-enhanced free-breathing 3D T1-weighted gradient-echo sequence for hepatobiliary MRI in patients with breath-holding difficulties. Eur Radiol 23:3087–3093. doi:10.1007/s00330-013-2910-2

    Article  CAS  PubMed  Google Scholar 

  10. Azevedo RM, de Campos ROP, Ramalho M, et al. (2011) Free-breathing 3D T1-weighted gradient-echo sequence with radial data sampling in abdominal MRI: preliminary observations. Am J Roentgenol 197:650–657. doi:10.2214/AJR.10.5881

    Article  Google Scholar 

  11. Schwenzer NF, Schmidt H, Claussen CD (2012) Whole-body MR/PET: applications in abdominal imaging. Abdom Imaging 37:20–28. doi:10.1007/s00261-011-9809-7

    Article  CAS  PubMed  Google Scholar 

  12. Schwarz AJ, Leach MO (2000) Implications of respiratory motion for the quantification of 2D MR spectroscopic imaging data in the abdomen. Phys Med Biol 45:2105–2116

    Article  CAS  PubMed  Google Scholar 

  13. Dawood M, Buther F, Stegger L, et al. (2009) Optimal number of respiratory gates in positron emission tomography: a cardiac patient study. Med Phys 36:1775–1784

    Article  PubMed  Google Scholar 

  14. Suramo I, Paivansalo M, Myllyla V (1984) Cranio-caudal movements of the liver, pancreas and kidneys in respiration. Acta Radiol Diagn (Stockh) 25:129–131

    CAS  Google Scholar 

  15. Grimm R, Fürst S, Dregely I, et al. (2013) Self-gated radial MRI for respiratory motion compensation on hybrid PET/MR systems. Med Image Comput Comput Assist Interv 16:17–24

    PubMed  Google Scholar 

  16. Judenhofer MS, Cherry SR (2013) Applications for preclinical PET/MRI. Semin Nucl Med 43:19–29. doi:10.1053/j.semnuclmed.2012.08.004

    Article  PubMed  Google Scholar 

  17. Slomka PJ, Dey D, Przetak C, Aladl UE, Baum RP (2003) Automated 3-dimensional registration of stand-alone (18)F-FDG whole-body PET with CT. J Nucl Med 44:1156–1167

    PubMed  Google Scholar 

  18. Forster GJ, Laumann C, Nickel O, et al. (2003) SPET/CT image co-registration in the abdomen with a simple and cost-effective tool. Eur J Nucl Med Mol Imaging 30:32–39. doi:10.1007/s00259-002-1013-0

    Article  PubMed  Google Scholar 

  19. Fin L, Daouk J, Morvan J, et al. (2008) Initial clinical results for breath-hold CT-based processing of respiratory-gated PET acquisitions. Eur J Nucl Med Mol Imaging 35:1971–1980. doi:10.1007/s00259-008-0858-2

    Article  PubMed  Google Scholar 

  20. Fin L, Daouk J, Bailly P, et al. (2012) Improved imaging of intrahepatic colorectal metastases with 18F-fluorodeoxyglucose respiratory-gated positron emission tomography. Nucl Med Commun 33:656–662. doi:10.1097/MNM.0b013e328351fce8

    Article  PubMed  Google Scholar 

  21. Daouk J, Leloire M, Fin L, et al. (2011) Respiratory-gated 18F-FDG PET imaging in lung cancer: effects on sensitivity and specificity. Acta Radiol 52:651–657. doi:10.1258/ar.2011.110018

    Article  PubMed  Google Scholar 

  22. Chang G, Chang T, Pan T, Clark JWJ, Mawlawi OR (2010) Implementation of an automated respiratory amplitude gating technique for PET/CT: clinical evaluation. J Nucl Med 51:16–24. doi:10.2967/jnumed.109.068759

    Article  PubMed Central  PubMed  Google Scholar 

  23. Kuhn J-P, Holmes JH, Brau ACS, et al. (2013) Navigator flip angle optimization for free-breathing T1-weighted hepatobiliary phase imaging with gadoxetic acid. J Magn Reson Imaging . doi:10.1002/jmri.24480

    Google Scholar 

  24. Nagle SK, Busse RF, Brau AC, et al. (2012) High resolution navigated three-dimensional T(1)-weighted hepatobiliary MRI using gadoxetic acid optimized for 1.5 Tesla. J Magn Reson Imaging 36:890–899. doi:10.1002/jmri.23713

    Article  PubMed Central  PubMed  Google Scholar 

  25. Lee ES, Lee JM, Yu MH, et al. (2014) High spatial resolution, respiratory-gated, t1-weighted magnetic resonance imaging of the liver and the biliary tract during the hepatobiliary phase of gadoxetic Acid-enhanced magnetic resonance imaging. J Comput Assist Tomogr 38:360–366. doi:10.1097/RCT.0000000000000055

    Article  PubMed  Google Scholar 

  26. Brendle CB, Schmidt H, Fleischer S, et al. (2013) Simultaneously acquired MR/PET images compared with sequential MR/PET and PET/CT: alignment quality. Radiology 268:190–199. doi:10.1148/radiol.13121838

    Article  PubMed  Google Scholar 

  27. Rakheja R, DeMello L, Chandarana H, et al. (2013) Comparison of the accuracy of PET/CT and PET/MRI spatial registration of multiple metastatic lesions. Am J Roentgenol 201:1120–1123. doi:10.2214/AJR.13.11305

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, University Of North Carolina at Chapel Hill, Old Clinic Bldg., CB 7510 – 2001, Chapel Hill, NC, 27599-7510, USA

    Miguel Ramalho, Mamdoh AlObaidy, Lauren M. Burke, Kiran K. Busireddy, Terence Z. Wong & Richard C. Semelka

  2. Siemens Medical Solution, Cary, NC, USA

    Brian M. Dale

  3. Department of Radiology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

    Abdulaziz AlSugair

Authors
  1. Miguel Ramalho
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  2. Mamdoh AlObaidy
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  3. Lauren M. Burke
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  4. Brian M. Dale
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  5. Kiran K. Busireddy
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  6. Terence Z. Wong
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  7. Abdulaziz AlSugair
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  8. Richard C. Semelka
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Correspondence to Richard C. Semelka.

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Ramalho, M., AlObaidy, M., Burke, L.M. et al. MR–PET co-registration in upper abdominal imaging: quantitative comparison of two different T1-weighted gradient echo sequences: initial observations. Abdom Imaging 40, 1426–1431 (2015). https://doi.org/10.1007/s00261-015-0460-6

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  • DOI: https://doi.org/10.1007/s00261-015-0460-6

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