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Liver parenchyma at the site of hypodense parafissural pseudolesion contains increased collagen

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Abstract

Purpose

To identify a histological substrate explaining the hypodense pseudolesion in the liver at the right side of the falciform ligament and the correlation with CT radiodensity.

Materials and methods

Tissue specimens were obtained from the right (pseudolesion) and left (control) side of the falciform ligament at the level of the left portal vein, in deceased adults during autopsy. Radiodensity was measured at the same locations at CT. Digital image analysis determined the amount of collagen and fat in histological sections, and the number of portal triads and central veins were counted. Glycogen content was visually assessed by the area percentage of the histological section.

Results

Specimens from 17 patients showed a 39% increase in collagen for the site of the pseudolesion compared to the contralateral side (p = 0.08). No significant differences were found for the amount of fat, glycogen, portal triads, or central veins. In one patient a pseudolesion was visible on CT, and this contained 52% more collagen than the control side.

Conclusion

The pseudolesion at the right parafissural side in the liver contains more collagen compared to the control left side, while there is no difference in fat or glycogen content or number of portal and hepatic veins. Collagen may be the cause of the pseudolesion.

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Abbreviations

CT:

Computed tomography

MRI:

Magnetic resonance imaging

PAS:

Periodic acid Schiff

HE:

Hematoxylin and eosin

EVG:

Elastin Van Gieson

HU:

Hounsfield unit

PMI:

Post-mortem interval

ICC:

Intraclass correlation coefficient

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Authors and Affiliations

  1. Department of Radiology and Nuclear Medicine, Radboud University Medical Centre, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands

    Lianne J. P. Sonnemans, Mathias Prokop & Willemijn M. Klein

  2. Department of Pathology, Radboud University Medical Centre, Nijmegen, The Netherlands

    Nils Köster & Jeroen A. W. M. van der Laak

Authors
  1. Lianne J. P. Sonnemans
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  2. Nils Köster
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  3. Mathias Prokop
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  4. Jeroen A. W. M. van der Laak
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  5. Willemijn M. Klein
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Correspondence to Willemijn M. Klein.

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Sonnemans, L.J.P., Köster, N., Prokop, M. et al. Liver parenchyma at the site of hypodense parafissural pseudolesion contains increased collagen. Abdom Imaging 40, 2306–2312 (2015). https://doi.org/10.1007/s00261-015-0442-8

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  • DOI: https://doi.org/10.1007/s00261-015-0442-8

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