Abstract
Purpose
The aims of this study were to investigate whether there is a difference in diagnostic value between vein to parenchyma strain ratio (VPSR) and muscle to parenchyma strain ratio (MPSR).
Methods
VPSR and MPSR were calculated via sonoelastography, and were recorded for comparison with histopathology. ROC analysis, the Mann–Whitney U test, the Kruskal–Wallis test, and Spearman’s rank correlation test were used for statistical analysis.
Results
The study included 59 cases of individuals who underwent biopsy (29 women, 30 men). When the threshold value for VPSR was set at 3.23, the sensitivity was 96.2% and the specificity was 83.3% (p < 0.001, F ≥ 1). When the threshold value was set at 3.01 for MPR, the sensitivity was 88.7% and the specificity was 83.3% (p < 0.001, F ≥ 1). The areas under the curve values were VPSR 0.95 and MPSR 0.92 for F ≥ 1, VPSR 0.94 and MPSR 0.92 for F ≥ 2, and VPSR 1.00 and MPSR 0.76 for F = 3 (p < 0.001). The Spearman’s correlation coefficient was 0.75, and a high positive concordance was found between VPSR and MPSR (p < 0.001).
Conclusions
In this study, a high positive correlation was observed between two strain ratios, and VPSR was found to be more reliable than MPSR in determining liver fibrosis.
Similar content being viewed by others
References
Friedman S, Schiano T (2004) Cirrhosis and its sequelae. In: Goldman L, Ausiello D (eds) Cecil textbook of medicine, 22nd edn. Philadelphia, PA: Saunders, pp 936–944
Guyot C, Lepreux S, Combe C, et al. (2006) Hepatic fibrosis and cirrhosis: the (myo)fibroblastic cell subpopulations involved. Int J Biochem Cell Biol 38:135–151
Mohamadnejad M, Montazeri G, Fazlollahi A, et al. (2006) Noninvasive markers of liver fibrosis and inflammation in chronic hepatitis B-virus related liver disease. Am J Gastroenterol 101:2537–2545
Bravo A, Sheth SG, Chopra S (2001) Liver biopsy. N Engl J Med 344:495–500
Shackel NA, McCaughan GW (2004) Liver biopsy: is it still relevant? Intern Med J 36:689–691
Siegel CA, Silas AM, Suriawianata AA, van Leeuwen DJ (2005) Liver biopsy: when and how? Clevel Clin J Med 72:199–224
Poynard T, Munteanu M, Bismut FI, et al. (2004) Prospective analysis of discordant results between biochemical markers and biopsy in patients with chronic hepatitis C. Clin Chem 50:1344–1355
Kanamoto M, Shimada M, Ikegami T, et al. (2009) Real time elastography for noninvasive diagnosis of liver fibrosis. J Hepatobiliary Pancreat Surg 16:437–463
Koizumi Y, Hirooka M, Kisaka Y, et al. (2011) Liver fibrosis in patients with chronic hepatitis C: noninvasive diagnosis by means of real-time tissue elastography-establishment of the method for measurement. Radiology 258:610–617
Goodman ZD (2007) Grading and staging systems for inflammation and fibrosis in chronic liver diseases. J Hepatol 47:598–607
Wang J, Guo L, Shi X, et al. (2012) Real-time elastography with a novel quantitative technology for assessment of liver fibrosis in chronic hepatitis B. Eur J Radiol 81:e31–e36
Aydin R, Elmali M, Polat AV, Danaci M, Akpolat I (2014) Comparison of muscle-to-nodule and parenchyma-to-nodule strain ratios in the differentiation of benign and malignant thyroid nodules: which one should we use? Eur J Radiol 83:e131–e136
Ophir J, Cespedes I, Ponnekanti H, Yazdi Y, Li X (1991) Elastography: a quantitative method for imaging the elasticity of biological tissues. Ultrason Imaging 13:111–134
Limei Xie PhD, Chen Xi, et al. (2012) Real-time elastography for diagnosis of liver fibrosis in chronic hepatitis B. J Ultrasound Med 31:1053–1060
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Altiparmak, B., Nural, M.S., Aydin, R. et al. Comparison of intrahepatic vein-to-liver parenchyma and intercostal muscle-to-liver parenchyma strain ratios in the assessment of liver fibrosis: which one should we use?. Abdom Imaging 40, 730–737 (2015). https://doi.org/10.1007/s00261-014-0294-7
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00261-014-0294-7