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Multimodality imaging of splenic lesions and the role of non-vascular, image-guided intervention

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Abstract

Splenic lesions are often incidentally detected on abdominal-computed tomography (CT), ultrasound, or magnetic resonance imaging (MRI), and these can pose a diagnostic challenge in patients with suspected or known malignancy. This review will discuss the multimodality imaging features of various benign and malignant splenic pathologies including trauma, infection, infarct, granulomatous disease, benign neoplasms such as hemangioma, hamartoma, and littoral cell angioma, cystic entities such as peliosis, splenic cysts, and pseudocysts, and malignant processes such as metastasis, lymphoma, angiosarcoma, and leiomyosarcoma. While several of these splenic pathologies have characteristic imaging features that are helpful in diagnosis, others have nonspecific findings. In such clinical dilemmas, image-guided intervention may be essential, and we therefore discuss the role of non-vascular, image-guided splenic interventions for diagnostic and therapeutic purposes. The radiologist can play a key part in the clinical diagnosis and management of splenic lesions, and therefore a thorough knowledge of the imaging features of splenic lesions and a thoughtful approach to their management is crucial.

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References

  1. Perkins JA (2010) Diseases of the white blood cells, lymph nodes, spleen and thymus. In: Kumar V, Abbas AK, Fausto N, Aster AC (eds) Robbins and cotran pathologic basis of disease, 8th edn. Philadelphia, PA: Saunders/Elsevier, pp 589–638

    Google Scholar 

  2. Berland LL (2013) Overview of white papers of the ACR incidental findings committee II on adnexal, vascular, splenic, nodal, gallbladder, and biliary findings. J Am Coll Radiol 10(9):672–674

    Article  PubMed  Google Scholar 

  3. McInnes MD, Kielar AZ, Macdonald DB (2011) Percutaneous image-guided biopsy of the spleen: systematic review and meta-analysis of the complication rate and diagnostic accuracy. Radiology 260(3):699–708

    Article  PubMed  Google Scholar 

  4. Bezerra AS, D’Ippolito G, Faintuch S, Szejnfeld J, Ahmed M (2005) Determination of splenomegaly by CT: is there a place for a single measurement? AJR Am J Roentgenol 184(5):1510–1513

    Article  PubMed  Google Scholar 

  5. Frank K, Linhart P, Kortsik C, Wohlenberg H (1986) Sonographic determination of spleen size: normal dimensions in adults with a healthy spleen. Ultraschall Med 7(3):134–137

    Article  CAS  PubMed  Google Scholar 

  6. Robertson F, Leander P, Ekberg O (2001) Radiology of the spleen. Eur Radiol 11(1):80–95

    Article  CAS  PubMed  Google Scholar 

  7. Pozo AL, Godfrey EM, Bowles KM (2009) Splenomegaly: investigation, diagnosis and management. Blood Rev 23(3):105–111

    Article  PubMed  Google Scholar 

  8. Spielmann AL, DeLong DM, Kliewer MA (2005) Sonographic evaluation of spleen size in tall healthy athletes. AJR Am J Roentgenol 184(1):45–49

    Article  PubMed  Google Scholar 

  9. Webb WR, Brant WE, Helms CA (1998) Fundamentals of body CT, 2nd edn. Philadelphia, PA: Saunders

    Google Scholar 

  10. Arber DA (2009) The spleen. In: Weidner N, Cote R, Suster S, Weiss L (eds) Modern surgical pathology, 2nd edn. Philadelphia, PA: Saunders/Elsevier, p 1513

    Google Scholar 

  11. Wasnik AP, Mazza MB, Lalchandani UR, Liu PS (2011) Normal and variant abdominal anatomy on magnetic resonance imaging. Magn Reson Imaging Clin N Am 19(3):521–545

    Article  PubMed  Google Scholar 

  12. Ito K, Mitchell DG, Honjo K, et al. (1996) Gadolinium-enhanced MR imaging of the spleen: artifacts and potential pitfalls. AJR Am J Roentgenol 167(5):1147–1151

    Article  CAS  PubMed  Google Scholar 

  13. Positron Clark P, Tomography Emission (2009) In: Dalrymple N, Leyendecker J, Oliphant M (eds) Problem solving in abdominal imaging. St.Louis, MO: Mosby/Elsevier, pp 81–84

    Google Scholar 

  14. Boscak A, Shanmuganathan K (2012) Splenic trauma: what is new? Radiol Clin North Am 50(1):105–122

    Article  PubMed  Google Scholar 

  15. Moore EE, Cogbill TH, Jurkovich GJ, et al. (1995) Organ injury scaling: spleen and liver (1994 revision). J Trauma 38(3):323–324

    Article  CAS  PubMed  Google Scholar 

  16. Clark TJ, Cardoza S, Kanth N (2011) Splenic trauma: pictorial review of contrast-enhanced CT findings. Emerg Radiol 18(3):227–234

    Article  PubMed  Google Scholar 

  17. Kamaya A, Weinstein S, Desser TS (2006) Multiple lesions of the spleen: differential diagnosis of cystic and solid lesions. Semin Ultrasound CT MR 27(5):389–403

    Article  PubMed  Google Scholar 

  18. Faught WE, Gilbertson JJ, Nelson EW (1989) Splenic abscess: presentation, treatment options, and results. Am J Surg 158(6):612–614

    Article  CAS  PubMed  Google Scholar 

  19. Rabushka LS, Kawashima A, Fishman EK (1994) Imaging of the spleen: CT with supplemental MR examination. Radiographics 14(2):307–332

    Article  CAS  PubMed  Google Scholar 

  20. Anderson SW, Lucey BC, Soto JA (2009) Nontrauma abdomen. In: Soto JA, Lucey BC (eds) Emergency radiology: the requisites, 1st edn. Philadelphia, PA: Mosby/Elsevier, pp 303–304

    Google Scholar 

  21. Elsayes KM, Narra VR, Mukundan G, et al. (2005) MR imaging of the spleen: spectrum of abnormalities. Radiographics 25(4):967–982

    Article  PubMed  Google Scholar 

  22. Al-Salem AH (2011) Splenic complications of sickle cell anemia and the role of splenectomy. ISRN Hematol 2011:864257

    PubMed Central  PubMed  Google Scholar 

  23. Ouyang HQ, Gong ZJ, Zha YF, Liu CS, Yang ZH (2013) Splenic siderotic nodules in patients with liver cirrhosis. Exp Ther Med 6(2):445–450

    PubMed Central  PubMed  Google Scholar 

  24. Selcuk D, Demirel K, Kantarci F, Mihmanli I, Ogut G (2005) Gamna-Gandy bodies: a sign of portal hypertension. Turk J Gastroenterol 16(3):150–152

    PubMed  Google Scholar 

  25. Chan YL, Yang WT, Sung JJ, Lee YT, Chung SS (2000) Diagnostic accuracy of abdominal ultrasonography compared to magnetic resonance imaging in siderosis of the spleen. J Ultrasound Med 19(8):543–547

    CAS  PubMed  Google Scholar 

  26. Aslam S, Sohaib S, Reznek RH (2008) Reticuloendothelial disorders: the spleen. In: Adam A, Dixon A, Grainger R, Allison D (eds) Grainger & Allison’s diagnostic radiology, 5th edn. Philadelphia, PA: Churchill Livingstone, pp 1759–1770

    Chapter  Google Scholar 

  27. Siegelman ES (2004) MRI of the spleen. In: Siegelman ES (ed) Body MRI, 1st edn. Philadelphia, PA: Saunders, p 197

    Google Scholar 

  28. Sharma SK, Smith-Rohrberg D, Tahir M, Mohan A, Seith A (2007) Radiological manifestations of splenic tuberculosis: a 23-patient case series from India. Indian J Med Res 125(5):669–678

    CAS  PubMed  Google Scholar 

  29. Adachi K (2011) Isolated splenic peliosis presenting with giant splenomegaly and severe coagulopathy. Am J Surg 202(2):e17–e19

    Article  PubMed  Google Scholar 

  30. Nakamoto DA (2008) Spleen. In: Haaga J, Dogra V, Forsting M, Gilkeson R, Ha H, Sundaram M (eds) CT and MRI of the whole body, 5th edn. Philadelphia, PA: Mosby/Elsevier, pp 1771–1803

    Google Scholar 

  31. Mathieson JR, Cooperberg PL (1998) The spleen. In: Rumack CM, Wilson SR, Charboneau JW (eds) Diagnostic ultrasound, 2nd edn. St. Louis: Mosby, pp 155–174

    Google Scholar 

  32. Cheuk W, Chan JKC (2007) Tumors of the lymphoreticular system: part B, the spleen. In: Fletcher C (ed) Diagnostic histopathology of the spleen, 3rd edn. Philadelphia, PA: Churchill Livingstone, pp 1304–1309

    Google Scholar 

  33. Abbott RM, Levy AD, Aguilera NS, Gorospe L, Thompson WM (2004) From the archives of the AFIP: primary vascular neoplasms of the spleen: radiologic–pathologic correlation. Radiographics 24(4):1137–1163

    Article  PubMed  Google Scholar 

  34. Ben-Izhak O, Bejar J, Ben-Eliezer S, Vlodavsky E (2001) Splenic littoral cell hemangioendothelioma: a new low-grade variant of malignant littoral cell tumour. Histopathology 39(5):469–475

    Article  CAS  PubMed  Google Scholar 

  35. Shah S, Wasnik A, Pandya A, Bude RO (2011) Multimodality imaging findings in image-guided biopsy proven splenic littoral cell angioma: series of three cases. Abdom Imaging 36(6):735–738

    Article  PubMed  Google Scholar 

  36. Kaza RK, Azar S, Al-Hawary MM, Francis IR (2010) Primary and secondary neoplasms of the spleen. Cancer Imaging 10:173–182

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  37. Bhatia K, Sahdev A, Reznek RH (2007) Lymphoma of the spleen. Semin Ultrasound CT MR 28(1):12–20

    Article  PubMed  Google Scholar 

  38. Lam KY, Tang V (2000) Metastatic tumors to the spleen: a 25-year clinicopathologic study. Arch Pathol Lab Med 124(4):526–530

    CAS  PubMed  Google Scholar 

  39. Davies CE, Davies AM, Kindblom LG, James SL (2010) Soft tissue tumors with muscle differentiation. Semin Musculoskelet Radiol 14(2):245–256

    Article  PubMed  Google Scholar 

  40. Keogan MT, Freed KS, Paulson EK, Nelson RC, Dodd LG (1999) Imaging-guided percutaneous biopsy of focal splenic lesions: update on safety and effectiveness. AJR Am J Roentgenol 172(4):933–937

    Article  CAS  PubMed  Google Scholar 

  41. Singh AK, Shankar S, Gervais DA, Hahn PF, Mueller PR (2012) Image-guided percutaneous splenic interventions. Radiographics 32(2):523–534

    Article  PubMed  Google Scholar 

  42. Thanos L, Dailiana T, Papaioannou G, et al. (2002) Percutaneous CT-guided drainage of splenic abscess. AJR Am J Roentgenol 179(3):629–632

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

The authors acknowledge Nilesh Gupta, MBBS, DNB (Raipur, India) for providing CT image in Fig. 12.

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The authors declare that they have no conflicts of interest.

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Correspondence to Ashish P. Wasnik.

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Gaetke-Udager, K., Wasnik, A.P., Kaza, R.K. et al. Multimodality imaging of splenic lesions and the role of non-vascular, image-guided intervention. Abdom Imaging 39, 570–587 (2014). https://doi.org/10.1007/s00261-014-0080-6

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