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Diagnostic efficiency of [68 Ga]Ga-DOTA-FAPI-04 in differentiating periprosthetic hip joint infection and aseptic failure

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European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

An Editorial to this article was published on 06 March 2023

Abstract

Purpose

To assess the efficiency of [68 Ga]Ga-DOTA-FAPI-04 in diagnosing periprosthetic hip joint infection and establish a diagnostic standard of clinical significance based on uptake pattern.

Methods

[68 Ga]Ga-DOTA-FAPI-04 PET/CT was performed in patients with symptomatic hip arthroplasty from December 2019 to July 2022. The reference standard was based on the 2018 Evidence-Based and Validation Criteria. Two diagnostic criteria, SUVmax and uptake pattern, were used to diagnose PJI. Meanwhile, original data were imported into IKT-snap to draw the view of interest, A.K. was used to extract features of clinical cases, and unsupervised clustering analysis was applied according to the groups.

Results

A total of 103 patients were included, 28 of whom had PJI. The area under the curve of SUVmax was 0.898, which was better than that of all of the serological tests. The cutoff value of SUVmax was 7.53, and the sensitivity and specificity were 100 and 72%, respectively. The sensitivity, specificity and accuracy of the uptake pattern were 100, 93.1 and 95%, respectively. In radiomics analysis, the features of PJI were significantly different from those of aseptic failure.

Conclusion

The efficiency of [68 Ga]Ga-DOTA-FAPI-04 PET/CT in diagnosing PJI showed promising results, and the diagnostic criteria of the uptake pattern were more clinically instructive. Radiomics also showed certain application prospects in the field of PJI.

Trial registration number

Trial registration: ChiCTR2000041204. Registered 24 September 2019.

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Data Availability

The data that support the results of this study are available on request from the corresponding author upon reasonable request.

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Funding

This work is supported by the National Key Research and Development Program of China (No. 2020YFC2004900).

Author information

Authors and Affiliations

  1. Department of Nuclear Medicine, The First Medical Centre, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, People’s Republic of China

    Yiqun Wang, Ruimin Wang, Xiaojun Zhang, Honghong Liu, Yan Chang, Qingxiao Li, Shulin Yao, Jinming Zhang & Jiahe Tian

  2. Department of Sports Medicine, Peking University Third Hospital, Beijing Key Laboratory of Sports Injuries, Institute of Sports Medicine of Peking University, Beijing, People’s Republic of China

    La Li, Yuanyuan Shi & Wenqiang Yan

  3. General Electric (GE) Healthcare China, Shanghai, People’s Republic of China

    Yanmei Wang

  4. Department of Interventional Ultrasound, The First Medical Centre, Chinese PLA General Hospital, Beijing, People’s Republic of China

    Erpeng Qi

  5. Department of Orthopedics, The First Medical Centre, Chinese PLA General Hospital, Beijing, People’s Republic of China

    Libo Hao, Wei Chai & Jiying Chen

  6. Department of Orthopedics, The Fourth Medical Centre, Chinese PLA General Hospital, Beijing, People’s Republic of China

    Libo Hao, Wei Chai & Jiying Chen

  7. Fangshan District, HighTech Atom Co., Ltd, No. 1 Sanqiang Road, Xinzhen, Beijing, People’s Republic of China

    Wuguo Shao

  8. China Isotope & Radiation Corporation, Haidian District, No. 66 Changwa Zhongjie, Beijing, People’s Republic of China

    Wuguo Shao

Authors
  1. Yiqun Wang
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Contributions

Y.Q.W., R.M.W. and L.L. wrote the original draft, H.H.L., Y.C., Q.X.L., Y.Y.S. and Y.M.W. performed the data curation and formal analysis, and E.P.Q., X.J.Z. and L.B.H. used the software, W.Q.Y., W.C. and S.L.Y. supervised and designed the project, W.G.S., J.M.Z., J.Y.C and J.H.T supervised, reviewed and edited the draft.

Corresponding authors

Correspondence to Jinming Zhang, Jiying Chen or Jiahe Tian.

Ethics declarations

Ethics approval

This single-center study was approved by the Ethics Committee of Chinese PLA General Hospital (registered at the Chinese Clinical Trial Registry: ChiCTR2000041204), and written informed consent was obtained from the patients prior to PET/CT examination.

Conflict of interest

All authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Publisher's note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

The authors Yiqun Wang, Ruimin Wang, and Xiaojun Zhang contributed equally to this manuscript and should be regarded as co-first authors.

The authors Jinming Zhang, Jiying Chen, Jiahe Tian contributed equally to this manuscript and should be regarded as co-corresponding authors.

This article is part of the Topical Collection on Orthopedics.

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Wang, Y., Wang, R., Zhang, X. et al. Diagnostic efficiency of [68 Ga]Ga-DOTA-FAPI-04 in differentiating periprosthetic hip joint infection and aseptic failure. Eur J Nucl Med Mol Imaging 50, 1919–1928 (2023). https://doi.org/10.1007/s00259-023-06146-y

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