Skip to main content

Advertisement

Log in

Amyloid imaging with PET: methodological issues and correlative studies

  • Focus on
  • Published:
European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. http://nobelprize.org/nobel_prizes/medicine/laureates/1908/ehrlich-lecture.html

  2. Nordberg A. Amyloid plaque imaging in vivo: current achievement and future prospects. Eur J Nucl Med Mol Imaging 2008;35(Suppl 1):S46–50.

    Article  PubMed  Google Scholar 

  3. Thompson PW, Ye L, Morgenstern JL, Sue L, Beach TG, Judd DJ, et al. Interaction of the amyloid imaging tracer FDDNP with hallmark Alzheimer's disease pathologies. J Neurochem 2009. doi:10.1111/j.1471–4159.2009.05996.x.

    PubMed  Google Scholar 

  4. Ikonomovic MD, Klunk WE, Abrahamson EE, Mathis CA, Price JC, Tsopelas ND, et al. Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease. Brain 2008;131(Pt 6):1630–45.

    Article  PubMed  Google Scholar 

  5. Svedberg MM, Hall H, Hellström-Lindahl E, Estrada S, Guan Z, Nordberg A, et al. [(11)C]PIB-amyloid binding and levels of Abeta40 and Abeta42 in postmortem brain tissue from Alzheimer patients. Neurochem Int 2008. doi:10.1016/j.neuint.2008.12.016.

    PubMed  Google Scholar 

  6. McNamee RL, Yee SH, Price JC, Klunk WE, Rosario B, Weissfeld L, et al. Consideration of optimal time window for Pittsburgh compound B PET summed uptake measurements. J Nucl Med 2009;50(3):348–55.

    Article  PubMed  CAS  Google Scholar 

  7. Raniga P, Bourgeat P, Fripp J, Acosta O, Villemagne VL, Rowe C, et al. Automated (11)C-PiB standardized uptake value ratio. Acad Radiol 2008;15(11):1376–89.

    Article  PubMed  Google Scholar 

  8. Razifar P, Engler H, Ringheim A, Estrada S, Wall A, Långström B. An automated method for delineating a reference region using masked volumewise principal-component analysis in 11C-PIB PET. J Nucl Med Technol 2009;37(1):38–44.

    Article  PubMed  Google Scholar 

  9. Mikhno A, Devanand D, Pelton G, Cuasay K, Gunn R, Upton N, et al. Voxel-based analysis of 11C-PIB scans for diagnosing Alzheimer's disease. J Nucl Med 2008;49(8):1262–9.

    Article  PubMed  Google Scholar 

  10. Mourik JE, Lubberink M, Schuitemaker A, Tolboom N, van Berckel BN, Lammertsma AA, et al. Image-derived input functions for PET brain studies. Eur J Nucl Med Mol Imaging 2009;36(3):463–71.

    Article  PubMed  Google Scholar 

  11. Yaqub M, Tolboom N, Boellaard R, van Berckel BN, van Tilburg EW, Luurtsema G, et al. Simplified parametric methods for [11C]PIB studies. Neuroimage 2008;42(1):76–86.

    Article  PubMed  Google Scholar 

  12. O'Keefe GJ, Saunder TH, Ng S, Ackerman U, Tochon-Danguy HJ, Chan JG, et al. Radiation dosimetry of {beta}-amyloid tracers 11C-PiB and 18F-BAY94–9172. J Nucl Med 2009;50(2):309–15.

    Article  PubMed  Google Scholar 

  13. Li Y, Rinne JO, Mosconi L, Pirraglia E, Rusinek H, DeSanti S, et al. Regional analysis of FDG and PIB-PET images in normal aging, mild cognitive impairment, and Alzheimer's disease. Eur J Nucl Med Mol Imaging 2008;35(12):2169–81.

    Article  PubMed  Google Scholar 

  14. Rabinovici GD, Jagust WJ, Furst AJ, Ogar JM, Racine CA, Mormino EC, et al. Abeta amyloid and glucose metabolism in three variants of primary progressive aphasia. Ann Neurol 2008;64(4):388–401.

    Article  PubMed  Google Scholar 

  15. Sojkova J, Beason-Held L, Zhou Y, An Y, Kraut MA, Ye W, et al. Longitudinal cerebral blood flow and amyloid deposition: an emerging pattern? J Nucl Med 2008;49(9):1465–71.

    Article  PubMed  CAS  Google Scholar 

  16. Okello A, Edison P, Archer HA, Turkheimer FE, Kennedy J, Bullock R, et al. Microglial activation and amyloid deposition in mild cognitive impairment: a PET study. Neurology 2009;72(1):56–62.

    Article  PubMed  CAS  Google Scholar 

  17. Wiley CA, Lopresti BJ, Venneti S, Price J, Klunk WE, DeKosky ST, et al. Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease. Arch Neurol 2009;66(1):60–7.

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

The author is grateful to Ms. Catherine Wrenn for her editorial support.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Giovanni Lucignani.

Additional information

“Focus on…” abridgements aim to highlight papers published within the past year and draw extensively on the texts and summaries of the articles referenced. Less recent citations are also included when deemed useful to provide background information on the topic reviewed.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lucignani, G. Amyloid imaging with PET: methodological issues and correlative studies. Eur J Nucl Med Mol Imaging 36, 1009–1014 (2009). https://doi.org/10.1007/s00259-009-1124-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00259-009-1124-y

Keywords

Navigation